Pediatric liposarcoma: A case series and literature review

Abstract

Liposarcoma is arare soft tissue sarcoma in children. While prognosis, clinical behavior, and response to therapy among the various histologic subtypes are well described in adults, data in children are limited. Here, we describe our experience treating 14 children with liposarcoma at a large, academic pediatric center and review the available pediatric literature. This comprehensive report adds treatment, survival, and genomic data to pediatric liposarcoma literature.

Update of Pediatric Lipomatous Lesions: A Clinicopathological, Immunohistochemical and Molecular Overview

“…Liposarcomas represent less than 2% of all pediatric soft tissue malignancies and nearly 90% of pediatric liposarcomas occur in the second decade of life. There is a female predominance and over 70% are myxoid types [ 10 , 77 , 78 , 79 , 80 ].…”

“…Over 50% of patients with PLPS were treated with surgery, as well as radiotherapy and chemotherapy (most commonly a doxorubicin-based treatment). They concluded that more data on the efficacy of different pharmaceuticals in treating liposarcomas is needed; however, the rarity of these tumors in the pediatric population poses a challenge to obtaining this data [ 80 ].…”

“…Patients diagnosed with MLPS and WDLPS, receiving minimal systemic therapy, had favorable outcomes: none experienced disease relapse or progression. The two patients with PLPS however, both died after receiving neoadjuvant chemotherapy with subsequent excision of the tumor [ 80 ].…”

“…The exact prognosis is not known due to the rarity of DDLPS in children and adolescents. However, the patient diagnosed with DDLPS in the study of Baday et al died, despite aggressive, multimodal therapy [ 80 ].…”

“…Myxoid liposarcoma (MLPS) is the most common liposarcoma subtype in pediatric patients. The lesions usually involve the extremities, trunk, head and neck, and abdominal regions [ 10 , 77 , 78 , 79 , 80 , 81 ]. There is no gender predilection and metastatic disease at initial presentation is uncommon [ 3 , 33 ].…”