Pediatric leukemia could be driven predominantly by non-synonymous variants in mitochondrial complex V in Mizo population from Northeast India

Vanlallawma, Andrew; Zami, Zothan; Pautu, Jeremy L.; Bawihtlung, Zothankima; Khenglawt, Lalfakzuala; Lallawmzuali, Doris; Chhakchhuak, Lalchhandama; Kumar, Nachimuthu Senthil

doi:10.1080/24701394.2020.1786545

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Notable examples encompass APC, AKT1 , and CDH1 in Gastric Cancer, KRT18, CYP4A11, SLC4A3, SLC26A5, KCNS1, ABCD1, YTHDC2, PINX1, TNRC6A, TACO1, LAMA1, ACP7 and ACP7 in Type 2 Diabetes, as well as MT-ND2, MT-ND6, NOTCH1 and FLT3 in Pediatric Leukaemia patients from Mizoram. 20 , 21 , 22 , 23 , 24 , 25 These genetic deviations may owe their existence to the distinctive attributes of the population, potentially serving as pivotal research entry points for exploring potential predisposition mechanisms. As an illustration, the DPYD gene encodes DPD, a determinant governing the bioavailability of 5-Fluorouracil, thus determining treatment efficacy and toxicity for solid tumour patients.…”

Section: Discussionmentioning

confidence: 99%

Cancer awareness, diagnosis and treatment needs in Mizoram, India: evidence from 18 years trends (2003–2020)

Zomawia,

Zami,

Vanlallawma

et al. 2023

The Lancet Regional Health - Southeast Asia

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Section: Discussionmentioning

confidence: 99%

Cancer awareness, diagnosis and treatment needs in Mizoram, India: evidence from 18 years trends (2003–2020)

Zomawia,

Zami,

Vanlallawma

et al. 2023

The Lancet Regional Health - Southeast Asia

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“…In pediatric AML, the activity of both mitochondrial Complex II and V are significantly elevated in BM mononuclear cells compared to controls ( 94 ). In a scientific report studying the mtDNA mutational patterns of pediatric leukemic cases from an endogamous tribal population in Northeast India, non-synonymous variants in mitochondrial Complex V are found to be the driving factors for diseases, demonstrating the role of Complex V in pediatric leukemia development ( 95 ).…”

Section: Aberrant Intrinsic Mitochondria Metabolic Processes As Emerg...mentioning

confidence: 99%

Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia

Feng,

Zhang,

Gao

et al. 2023

Front. Oncol.

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Chemoresistance often complicates the management of cancer, as noted in the instance of acute myeloid leukemia (AML). Mitochondrial function is considered important for the viability of AML blasts and appears to also modulate chemoresistance. As mitochondrial metabolism is aberrant in AML, any distinct pathways could be directly targeted to impact both cell viability and chemoresistance. Therefore, identifying and targeting those precise rogue elements of mitochondrial metabolism could be a valid therapeutic strategy in leukemia. Here, we review the evidence for abnormalities in mitochondria metabolic processes in AML cells, that likely impact chemoresistance. We further address several therapeutic approaches targeting isocitrate dehydrogenase 2 (IDH2), CD39, nicotinamide phosphoribosyl transferase (NAMPT), electron transport chain (ETC) complex in AML and also consider the roles of mesenchymal stromal cells. We propose the term “mitotherapy” to collectively refer to such regimens that attempt to override mitochondria-mediated metabolic reprogramming, as used by cancer cells. Mounting evidence suggests that mitotherapy could provide a complementary strategy to overcome chemoresistance in liquid cancers, as well as in solid tumors.

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Overexpression of REC8 induces aberrant gamete meiotic division and contributes to AML pathogenesis - a multiplexed microarray analysis and mendelian randomization study

Hua,

Qi,

Zhou

et al. 2024

Ann Hematol

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Pediatric leukemia could be driven predominantly by non-synonymous variants in mitochondrial complex V in Mizo population from Northeast India

Cited by 3 publications

References 27 publications

Cancer awareness, diagnosis and treatment needs in Mizoram, India: evidence from 18 years trends (2003–2020)

Cancer awareness, diagnosis and treatment needs in Mizoram, India: evidence from 18 years trends (2003–2020)

Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia

Overexpression of REC8 induces aberrant gamete meiotic division and contributes to AML pathogenesis - a multiplexed microarray analysis and mendelian randomization study

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