Pediatric isolated cortical (Ectopic) anaplastic ependymoma

Kharosekar, Hrushikesh; Bhide, Anuj; Velho, Vernon; Bijwe, Sanjay

doi:10.4103/1793-5482.181133

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Ependymomas recur more frequently in the initial location after local failure. Kharosekar et al ( 15 ) believed that if the tumor was completely located in the cortex, the patient might have a better prognosis. And, Saito et al ( 16 ) reported that anaplastic ependymomas can disseminate within the central nervous system without local failure.…”

Section: Discussionmentioning

confidence: 99%

Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report

Zhang,

Liu,

Zhang

et al. 2024

Front. Neurol.

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BackgroundEpendymomas mostly locate in the infratentorial region and often occur in children. Anaplastic ependymomas account for 45–47% of supratentorial and 15–17% of infratentorial ependymomas, also known as malignant ependymomas. Adult supratentorial extraventricular anaplastic ependymoma (SEAE) is rare in clinical practice, and only a few cases have been reported so far, and there is no clinical study with large sample size. We report a case of adult supratentorial extraventricular anaplastic ependymoma in the occipital lobe with cerebrospinal fluid dissemination metastases.Case descriptionA 58-year-old female patient presented with unexplained pain in multiple parts of the body for the past half a year, mainly manifested as pain in the head, abdomen and chest. On August, 2022, Head MRI of the patient showed abnormal signal shadow in the left occipital lobe, which was considered a malignant lesion. The patient underwent tumor resection under general anesthesia on September 3, 2022. Postoperative pathological examination showed anaplastic ependymoma. The postoperative follow-up head MRI showed multiple cerebrospinal fluid dissemination metastases in the brain.ConclusionAdult SEAE is a rare tumor with high malignancy and have a tendency to disseminate into the CSF, resulting in drop metastases. Immunohistochemistry is very important for the diagnosis of SEAE. It is recommended to administer adjuvant chemotherapy or radiation therapy appropriately after surgery, based on the tumor being completely resected as much as possible.

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Section: Discussionmentioning

confidence: 99%

Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report

Zhang,

Liu,

Zhang

et al. 2024

Front. Neurol.

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Clinicopathological and Genetic Features of Supratentorial Cortical Ependymomas

et al. 2019

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Supratentorial cortical ependymoma: A systematic literature review and case illustration

et al. 2022

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Cortical ependymomas are currently not considered a subgroup of supratentorial ependymomas; however, there is a growing body of literature investigating the natural history of these lesions compared to supratentorial ependymomas. We performed a systematic literature review of cortical ependymomas with a focus on the natural history, clinical characteristics, and clinical outcomes of these lesions as compared to supratentorial ependymomas. Our search revealed 153 unique cases of cortical ependymomas. The mean age on presentation was 21.2 years. Males and females comprised 58.8% (90/153) and 41.2% (63/153) of cases, respectively. The most common presenting symptom was seizure activity occurring in 44.4% of the cohort (68/153). The recently recognized C11orf95-RELA fusion was identified in 13.7% of the cohort (21/153) and 95.5% of cases (21/22) reporting molecular characterization. World Health Organization grades 2 and 3 were reported in 52.3% (79/151) and 47.7% (72/151) of cases, respectively. The frontal lobe was involved in the majority of cases (54.9%, 84/153). Gross total resection was achieved in 80.4% of cases (123/153). Tumor recurrence was identified in 27.7% of cases (39/141). Mean clinical follow-up was 41.3 months. Mean overall survival of patients who expired was 27.4 months whereas mean progression-free survival was 15.0 months. Comparatively, cortical ependymomas with C11orf95- RELA fusions and supratentorial ependymomas with C11orf95 RELA fusions exhibited differing clinical outcomes. Further studies with larger sample sizes are necessary to investigate the significance of RELA fusions on survival in cortical ependymomas and to determine whether cortical ependymomas with C11orf95- RELA fusions should be classified as a distinct entity.

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Pediatric isolated cortical (Ectopic) anaplastic ependymoma

Cited by 4 publications

References 3 publications

Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report

Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report

Clinicopathological and Genetic Features of Supratentorial Cortical Ependymomas

Supratentorial cortical ependymoma: A systematic literature review and case illustration

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