Pediatric Intestinal Retransplantation: Techniques, Management, and Outcomes

Abstract

Improved long-term survival and outcome in pediatric Re-ITx may be attributed to improvements in initial immunosuppression protocols, technical modifications, proper timing, and improved infectious disease monitoring. Careful patient selection and posttransplant management are essential for successful long-term outcome.

Intestinal Retransplantation: Analysis of Organ Procurement and Transplantation Network Database

“…This result was similar to those from the singlecenter series reported by Mazariegos et al (10). In this report, immunosuppression before the retransplant, the timing of the enterectomy, and a period of hyperalimentation after the retransplant were all considered important for outcome (10). In our analysis, for adults mainly, rejection was the major cause of graft failure.…”

“…More recent single-center data have shown better results (10). Magee et al (3) reported liver, kidney, heart, and lung retransplant outcomes during the most recent decade in the United States; however, they did not address ITx retransplants.…”

Emerging role of donor-specific anti–human leukocyte antigen antibody determination for clinical management after solid organ transplantation

“…Improved long-term survival and outcomes in pediatric intestinal transplantation has been observed both in primary and in retransplantations [33]. The increased success has been attributed to many clinical and technical modifications, including posttransplantation immune monitoring.…”

Comparable outcomes in intestinal retransplantation: Single‐center cohort study

“…There were 18 patients who received a retransplantation also contributed in primary transplants (n = 200). However, the data were analyzed based on events (not on patients) as observational units, as previously done by us and other groups . The data were summarized using means with standard deviations, or medians with interquartile ranges for continuous variables, and percentages for discrete variables.…”