Pediatric infratentorial meningiomas: a series of 19 cases and review of the literature

Hai, Liu; Luo, Wei; Li, Jiaxin; Yang, Jun; Xu, Yulun

doi:10.1007/s00381-017-3362-9

Cited by 8 publications

(22 citation statements)

References 34 publications

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“…30 Gamma knife and conventional radiotherapy are also used as adjuvant therapies for pediatric meningiomas that cannot be completely resected due to their location. 31 A retrospective analysis by Dudley et al showed that a higher percentage of children/adolescents and young adults with meningioma are treated with radiotherapy compared to adults, 3 even if its role and impact on prognosis are not clear. Upfront radiotherapy is associated with worse RFS but does not appear to have a significant effect on overall survival; it should be noted that in the meta-analysis by Kotecha et al the number of patients who underwent upfront radiotherapy was small and the dose, type, and rationale behind the decision to irradiate were unknown.…”

Section: Discussionmentioning

confidence: 99%

Proton therapy: A therapeutic opportunity for aggressive pediatric meningioma

Rombi

Ruggi

Sardi

et al. 2021

Pediatric Blood & Cancer

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Meningiomas are an extremely rare histology among pediatric brain tumors, and there is a shortage of literature on their management. Proton therapy is currently used safely and effectively for many types of both pediatric and adult cancer, and its main advantage is the sparing of healthy tissues from radiation, which could translate in the reduction of late side effects. We review the literature on radiotherapy and proton therapy for pediatric meningiomas and report clinical outcomes for two aggressive pediatric meningiomas we treated with protons. Proton therapy might be a safe and effective therapeutic option for this rare subgroup of tumors.

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Section: Discussionmentioning

confidence: 99%

Proton therapy: A therapeutic opportunity for aggressive pediatric meningioma

Rombi

Ruggi

Sardi

et al. 2021

Pediatric Blood & Cancer

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“…Meningiomas are the second most common primary tumors of the central nervous system that occur in adults but are uncommon in children and adolescents and represent 1–2% of intracranial tumors in children [1, 2]. Pediatric meningiomas (PMs) differ from their adult counterparts by their atypicality of location, higher rates of malignant change, and recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…For supratentorial meningiomas, the most common presenting signs and symptoms are raised intracranial pressure (headache, vomiting, and papilledema) and seizures. While, for infratentorial meningiomas, the most frequent signs are defects of the cranial nerves [1, 10, 11].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Cerebral Meningioma: A Single-Center Study with 10 Children Not Associated with Neurofibromatosis Type 2 and Literature Review

Opoku¹,

Yang²,

Sun³

et al. 2022

Pediatr Neurosurg

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Introduction: Pediatric meningiomas are rare tumors, they differ from their adult counterparts by their atypicality of location, higher rates of malignant change, male preponderance, recurrence and sometimes their association with neurofibromatosis. This case series analyzes the clinical behavior, pathological presentation, location and its association with Neurofibromatosis type 2 (NF2). Methods: This case series consists of pediatric patients between the ages of 4 and 16 years who were hospitalized in the neurosurgical department of our hospital from 2012 to 2021 with different neurological symptoms and a literature view using PubMed/Medline database. Results: 60% of the patients were males whiles 40% were females. The most common neurological manifestation were signs of increased intracranial pressure. NF2 was absent in all patients. The predominant histopathology subtype is Atypical and WHO Grade II representing 30% and 40% respectively. Conclusion: This study supports the relationship between NF2 and pediatric cerebral meningioma but at a lower concomitant rate from 0 to 13% taking into consideration our original data and the literature review, contrasting some reported cases which suggest rates as high as 33%, 50% and 100% in a very small number of patients. Gross total resection (GTR) without post operatory radiation therapy for non-malignant and non NF2 associated pediatric meningioma (PM) proved to be a sufficient and a good treatment option.

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“…

MeningioMas represent less than 3% of pediatric CNS tumors, 1 and when they do occur in children, the vast majority (approximately 90%) are supratentorial. 1,2 Pediatric cerebellopontine angle (CPA) meningiomas are thus exceedingly rare. 3 Described treatments typically involve radiation and/or resection, most commonly via a retrosigmoid craniotomy, 1 with the majority of surgically treated patients being 4 years of age or older.

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mentioning

confidence: 99%

“…3 Described treatments typically involve radiation and/or resection, most commonly via a retrosigmoid craniotomy, 1 with the majority of surgically treated patients being 4 years of age or older. 1,4 Although use of skull base approaches in the pediatric population is both relatively limited and potentially complicated by differences in skull base anatomy between children and adults, 5-8 more complex approaches, such as a translabyrinthine craniotomy with nerve grafting due to tumor infiltration into the fallopian canal, have been reported for pediatric CPA meningiomas. 4 In this paper we present the use of a middle fossa approach for the successful treatment of a symptomatic CPA meningioma in a 22-month-old, with a focus on the surgical technique due to the rarity of skull base approaches performed in this population.…”

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confidence: 99%

Middle fossa approach for a pediatric facial nerve meningioma

Rennert

Levy

Plonsker

et al. 2020

Journal of Neurosurgery: Pediatrics

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Pediatric cerebellopontine angle (CPA) meningiomas are extremely rare and are usually treated with a retrosigmoid surgical approach or radiation. The authors present the use of a middle fossa approach for the treatment of a symptomatic CPA meningioma in a 22-month-old female. The patient initially presented at 17 months with isolated progressive, long-standing right-sided facial weakness. MRI demonstrated a 5.0 × 5.0–mm right CPA lesion just superior to the cisternal segment of cranial nerve (CN) VII, which demonstrated growth on interval imaging. At 22 months of age she underwent a successful middle fossa craniotomy, including wide exposure of the porus acusticus, allowing for a gross-total resection with preservation of CNs VII and VIII. Pathological analysis revealed a WHO grade I meningioma. The patient remained neurologically stable on follow-up. The middle fossa approach can be used to safely access the CPA in properly selected pediatric patients.

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Pediatric infratentorial meningiomas: a series of 19 cases and review of the literature

Cited by 8 publications

References 34 publications

Proton therapy: A therapeutic opportunity for aggressive pediatric meningioma

Proton therapy: A therapeutic opportunity for aggressive pediatric meningioma

Pediatric Cerebral Meningioma: A Single-Center Study with 10 Children Not Associated with Neurofibromatosis Type 2 and Literature Review

Middle fossa approach for a pediatric facial nerve meningioma

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