Pediatric Inflammatory Bowel Disease: What Children Can Teach Adults

Hait, Liz; Bousvaros, Athos; Grand, Richard J.

doi:10.1097/01.mib.0000166932.66853.fd

Cited by 36 publications

(22 citation statements)

References 74 publications

(114 reference statements)

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“…Previous reports have suggested that childhood inflammatory bowel disease (IBD) has several clinical features that are distinct from those in adults [1][2][3][4][5][6]. The incidence of IBD in children is lower compared to that in adults.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan

et al. 2010

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“…Their prevalence has been on rise with children and adolescent currently accounting for approximately 30% of IBD patients [3,4] . Although the precise etiology of IBD remains elusive, both animal models and human studies point towards a strong genetic susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases

Cucchiara

Latiano

Palmieri

et al. 2007

WJG

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AIM:To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predisposition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS:Two hundred patients with Crohn's disease (CD), 186 ulcerative colitis (UC) patients, 434 parents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS:Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001).Homozygosis for both OCTN1/2 variants was more common in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an increased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was more frequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed.

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“…In recent years, IBD prevalence has been increasing among children and adolescents, with more than 10% of patients diagnosed before 18 y of age, and 30% diagnosed before their 21st birthday (1). The etiology of IBD is still largely unknown.…”

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confidence: 99%

Reduced Intracellular T-Helper 1 Interferon-Gamma in Blood of Newly Diagnosed Children With Crohn's Disease and Age-Related Changes in Th1/Th2 Cytokine Profiles

et al. 2008

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ABSTRACT:Abnormal cytokine production by T-helper 1 (Th1)/ T-helper 2 (Th2) lymphocytes has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Few studies have examined Th1/Th2 cytokine status in pediatric IBD patients, and results have been inconsistent. We used flow cytometric detection of intracellular IFN-␥/IL-4 cytokine production to investigate CD4 ϩ , Th1, and Th2 cells in the peripheral blood of children with untreated, newly diagnosed Crohn's disease (CD) (n ϭ 23) and matched healthy controls (n ϭ 49). Th1 cytokine levels were lower in CD patients compared with controls (p ϭ 0.006) and strongly correlated with levels of albumin and hematocrit (r ϭ 0.51, p ϭ 0.007 and r ϭ 0.35, p ϭ 0.052, respectively). An age-dependent increase in Th1 cells was observed (p Ͻ 0.0005); however, no correlation was found between age, clinical end points, %CD4ϩ , or Th2 cell numbers. In conclusion, the Th1 cytokine levels in blood are lower in early onset CD patients than in healthy children and are directly associated with diseaserelated clinical parameters. In future studies of pediatric IBD patients, it will be critical to consider the effect of age and disease progression on cytokine status in intestinal mucosa and peripheral blood. (Pediatr Res 63: 257-262, 2008)

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Pediatric Inflammatory Bowel Disease: What Children Can Teach Adults

Cited by 36 publications

References 74 publications

Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan

Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan

Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases

Reduced Intracellular T-Helper 1 Interferon-Gamma in Blood of Newly Diagnosed Children With Crohn's Disease and Age-Related Changes in Th1/Th2 Cytokine Profiles

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