Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, Canada

Carroll, Matthew; Hamilton, Zachary; Gill, H; Simkin, Jonathan; Smyth, Matthew D.; Espinosa, V.; Bressler, Brian; Jacobson, Kevan

doi:10.1097/mib.0000000000000651

Cited by 21 publications

(22 citation statements)

References 38 publications

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“…Walker et al studied the phenotype of UC in Northwest London; 63% of South Asian UC patients had extensive colitis compared with 42.5% of the White European cohort ( p < 0.0001) [12]. Two Canadian paediatric studies in British Columbia have also demonstrated more extensive disease in the South Asian population; the most recent study by Carroll et al demonstrated shorter symptom duration with a requirement for earlier escalation of therapy [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

Misra

Askari

Faiz

et al. 2016

Canadian Journal of Gastroenterology and Hepatology

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Introduction. Previous epidemiological studies suggest a higher rate of pancolonic disease in South Asians (SA) compared with White Europeans (WE). The aim of the study was to compare colectomy rates for ulcerative colitis (UC) in SA to those of WE. Methods. Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics, HES) between 1997 and 2012 according to ICD-10 diagnosis code K51 for UC. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group. Results. Of 212,430 UC cases, 73,318 (35.3%) were coded for ethnicity. There was no significant difference in the colectomy rate between SA and WE (6.93% versus 6.90%). Indians had a significantly higher colectomy rate than WE (9.8% versus 6.9%, p < 0.001). Indian patients were 21% more likely to require colectomy for UC compared with WE group (OR: 1.21, 95% CI: 1.04–1.42, and p = 0.001). Conclusions. Given the limitations in coding, the colectomy rate in this cohort was higher in Indians compared to WE. A prospectively recruited ethnic cohort study will decipher whether this reflects a more aggressive phenotype or is due to other confounding factors.

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Section: Introductionmentioning

confidence: 99%

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

Misra

Askari

Faiz

et al. 2016

Canadian Journal of Gastroenterology and Hepatology

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“…There were 20 studies examining disease phenotype in relation to migrants or race (Tables 5 6 7 8 and 9 ). Fourteen studies were conducted in the United States[ 22 - 34 ] and four in the United Kingdom[ 15 , 35 - 37 ], with the remaining two from Canada and Malaysia[ 38 , 39 ]. Sixteen studies were single centre, three multicentre[ 24 , 31 , 35 ] and only one was prospective[ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…SA group was compared with Caucasians in four studies and all reported on both location and disease behaviour (Table 5 ). Two were from the United Kingdom[ 35 , 36 ], one from the United States[ 22 ], and one from Canada[ 38 ]. Two studies (United Kingdom and Canada) showed SA significantly more likely to have colonic disease[ 35 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

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Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups

Misra

Faiz

Munkholm

et al. 2018

WJG

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AIMTo summarise the current literature and define patterns of disease in migrant and racial groups.METHODSA structured key word search in Ovid Medline and EMBASE was undertaken in accordance with PRISMA guidelines. Studies on incidence, prevalence and disease phenotype of migrants and races compared with indigenous groups were eligible for inclusion.RESULTSThirty-three studies met the inclusion criteria. Individual studies showed significant differences in incidence, prevalence and disease phenotype between migrants or race and indigenous groups. Pooled analysis could only be undertaken for incidence studies on South Asians where there was significant heterogeneity between the studies [95% for ulcerative colitis (UC), 83% for Crohn’s disease (CD)]. The difference between incidence rates was not significant with a rate ratio South Asian: Caucasian of 0.78 (95%CI: 0.22-2.78) for CD and 1.39 (95%CI: 0.84-2.32) for UC. South Asians showed consistently higher incidence and more extensive UC than the indigenous population in five countries. A similar pattern was observed for Hispanics in the United States. Bangladeshis and African Americans showed an increased risk of CD with perianal disease.CONCLUSIONThis review suggests that migration and race influence the risk of developing inflammatory bowel disease. This may be due to different inherent responses upon exposure to an environmental trigger in the adopted country. Further prospective studies on homogenous migrant populations are needed to validate these observations, with a parallel arm for in-depth investigation of putative drivers.

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“…The data describe an ethnically unique clinical phenotype, where South Asian children had a higher proportion of UC, shorter symptom duration, more extensive colonic disease, and were more likely to require earlier escalation of therapy. 12 There are several reasons why findings in 1 population might not be replicated in another. Disease-associated alleles of a specific gene may vary substantially in frequency in different ethnic groups.…”

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confidence: 99%

Inflammatory Bowel Disease: A Global Disease That Needs a Broader Ensemble of Populations

Franke

2017

Gastroenterology

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Pediatric Inflammatory Bowel Disease Among South Asians Living in British Columbia, Canada

Abstract: These data describe an ethnically unique clinical phenotype, where SA children have a higher proportion of UC, shorter symptom duration, more extensive colonic disease, and are more likely to require earlier escalation of therapy.

Cited by 21 publications

References 38 publications

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study

Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups

Inflammatory Bowel Disease: A Global Disease That Needs a Broader Ensemble of Populations

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