Pediatric Inflammatory Bowel Disease: A Multicenter Study of Changing Trends in Argentina Over the Past 30 Years

Arcucci, Maria Soledad; Contreras, Mónica; Gallo, Julieta; Antoniska, Mariela Andrea; Busoni, Verónica; Tennina, Cecilia; D’Agostino, Daniel; Kakisu, Maria Hisae; Weyersberg, Christian; Orsi, Marina

doi:10.5223/pghn.2022.25.3.218

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…29 Arcucci et al described a retrospective cohort of 756 pediatric patients with IBD in Argentina (54% with UC, 33% with UC, and 13% with IBD-U). 30 Authors found significantly higher use of anti-TNF agents in patients with CD compared with UC (28.8 versus 11.9%, p < 0.001). Notably, a significant increase in biologic penetration was seen in 2008-2017 compared to before 2007 (36.7 versus 4%, p < 0.001).…”

Section: Penetration Of Biological Therapies In South Americamentioning

confidence: 94%

“…Notably, a significant increase in biologic penetration was seen in 2008–2017 compared to before 2007 (36.7 versus 4%, p < 0.001). 30 …”

Section: Biological Therapies Penetration In Latammentioning

confidence: 99%

“…Notably, a significant increase in biologic penetration was seen in 2008-2017 compared to before 2007 (36.7 versus 4%, p < 0.001). 30 In a single-center cohort study from Chile, Simian et al included 716 patients with IBD (71% with UC, 27% with CD, and 2% with IBD-U). There was a significantly higher use of biologics in patients with CD compared to UC (34 versus 7%, p < 0.001).…”

Section: Penetration Of Biological Therapies In South Americamentioning

confidence: 99%

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IBD barriers across the continents: a continent-specific analysis: Latin America

Queiroz

Martins

Quaresma

et al. 2023

Therap Adv Gastroenterol

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Latin America (LATAM) is a large region comprising 47 countries and territories. Each one carries a different cultural and historical background, diverse political systems, and a particular approach to healthcare management. There is a lack of high-quality data on the epidemiology of inflammatory bowel diseases (IBD) in this region, including broad and detailed information about the penetration of biological and advanced therapies as treatment strategies. From an IBD perspective, patients experience, in general, fragmentations and inequities in the healthcare systems, with different and usually delayed access to qualified health services. This review explores the barriers to accessing IBD care throughout LATAM. The authors compiled data from multiple sources, such as studies focusing on epidemiology, biological penetration, and surgical rates. In addition, overall access to IBD treatments was assessed through a questionnaire distributed to physicians in LATAM via email and direct messaging to capture local perspectives.

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Section: Penetration Of Biological Therapies In South Americamentioning

confidence: 94%

“…Notably, a significant increase in biologic penetration was seen in 2008–2017 compared to before 2007 (36.7 versus 4%, p < 0.001). 30 …”

Section: Biological Therapies Penetration In Latammentioning

confidence: 99%

Section: Penetration Of Biological Therapies In South Americamentioning

confidence: 99%

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IBD barriers across the continents: a continent-specific analysis: Latin America

Queiroz

Martins

Quaresma

et al. 2023

Therap Adv Gastroenterol

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Epidemiology of pediatric inflammatory bowel disease categorized by age subgroups in Korea

Kim,

Kim

et al. 2024

Pediatrics International

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BackgroundPediatric inflammatory bowel disease (PIBD) affects different age groups and its incidence is increasing worldwide. However, there is a lack of research focusing on age subgroups in Asian countries. In this nationwide population‐based study, we investigated the epidemiology of PIBD among different age subgroups in Korea.MethodsWe analyzed Korean health administration data from 2005 to 2016. Data were divided by age at diagnosis as follows: group 1, 0–1 years; group 2, 2–5 years; group 3, 6–9 years; group 4, 10–16 years. We analyzed the overall incidence, temporal changes, and regional differences by age subgroups, using Poisson regression analysis.ResultsFrom 2005 to 2016, 2734 inflammatory bowel disease (IBD) cases were diagnosed among patients under 17 years of age. In the overall population, the incidence rate of PIBD over the entire study period was 2.248/105 person‐years (PY), significantly increasing from 1.173/105 PY in 2005–2007 to 3.267/105 PY in 2014–2016. The incidence rates in groups 1 and 2 remained unchanged, whereas those of groups 3 and 4 increased significantly. The same trend was observed when analyzed separately for Crohn's disease (CD) and ulcerative colitis (UC). The incidence rates of CD in groups 3 and 4 showed differences between metropolitan and non‐metropolitan areas, whereas those in groups 1 and 2, and UC of all age subgroups showed no difference.ConclusionsThe temporal trend and regional differences of PIBD differed among age subgroups, suggesting that genetic and environmental factors have varying impacts on IBD development across different subgroups.

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The Paradoxical Influence of Amerindian Ancestry on Clinical Outcomes in Crohn’s Disease and Ulcerative Colitis: Insights from a Chilean Cohort.

Perez-Jeldres,

Bustamante,

Alvares

et al. 2024

Preprint

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Background. Research in Inflammatory Bowel Disease (IBD) assessing the genetic structure and its association with IBD phenotypes is needed, especially in IBD-underrepresented populations such as the South American IBD population. Aim. We examine the correlation between Amerindian ancestry and IBD phenotypes within a South American cohort and investigate the association between previously identified IBD risk variants and phenotypes. Methods. We assessed the ancestral structure (IBD=291, Controls=51) to examine the association between Amerindian ancestry (AMR) and IBD variables. Additionally, we analyzed the influence of known IBD genetic risk factors on disease outcomes. We employed statistical tests to compare the different groups. Results. The median distribution of global ancestry was 58% European, 39% Amerindian, and 2% African. There were no significant differences in IBD risk based on ancestry proportion between cases and controls. Ulcerative colitis (UC) patients diagnosed before age 40 had a higher median Amerindian ancestry proportion (39.9% versus 37.4%, P value = 0.01). Conversely, UC patients with prolonged clinical and endoscopy remission had a lower median Amerindian ancestry proportion (35% versus 39%, P value = 0.02). In the Crohn’s Disease (CD) group, the median Amerindian ancestry proportion was lower in the group with perianal disease (33.5% versus 39.5%, P value = 0.03). Only 6% of patients with resective surgery had a higher Amerindian ancestry proportion. Conclusion. Our study highlights the impact of Amerindian ancestry on IBD phenotypes, suggesting a role for genetic and ancestral factors in disease phenotype. Further investigation is needed to unravel the underlying mechanisms driving these associations.

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Pediatric Inflammatory Bowel Disease: A Multicenter Study of Changing Trends in Argentina Over the Past 30 Years

Cited by 3 publications

References 29 publications

IBD barriers across the continents: a continent-specific analysis: Latin America

IBD barriers across the continents: a continent-specific analysis: Latin America

Epidemiology of pediatric inflammatory bowel disease categorized by age subgroups in Korea

The Paradoxical Influence of Amerindian Ancestry on Clinical Outcomes in Crohn’s Disease and Ulcerative Colitis: Insights from a Chilean Cohort.

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