Pediatric Infections in the Intensive Care Unit (ICU)

Anand, Sachit; Bajpai, Minu; Goel, Prabudh

doi:10.1007/978-981-15-4039-4_24

Infectious Diseases in the Intensive Care Unit 2020

DOI: 10.1007/978-981-15-4039-4_24

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Pediatric Infections in the Intensive Care Unit (ICU)

Sachit Anand

Minu Bajpai

Prabudh Goel

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2023

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Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU

Saggers,

Mothibi,

Irwin

et al. 2023

Curr Infect Dis Rep

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Purpose of Review Antimicrobial resistance continues to increase throughout the world, with the impact on critically ill children in low- and middle-income paediatric intensive care units largely unknown. Recent Findings There has been a global shift indicating a predominance of Gram-negative bacilli among multidrug-resistant isolates. A 4-year review (2019 to 2022) found a progressive and substantial increase in the incidence of carbapenem-resistant Klebsiella pneumoniae (29% to 51%) alongside high levels of carbapenem-resistant Acinetobacter baumannii (93%) within the paediatric intensive care unit at the Chris Hani Baragwanath Academic Hospital in South Africa. The pharmacological treatment of these infections relies heavily on the continued use of carbapenems, often in combination with colistin. Summary The burden of antimicrobial resistance is disproportionately borne, particularly within sub-Saharan Africa and South Asia. The resource-constrained South African public healthcare system, already significantly burdened by both HIV and TB, continues to face several challenges in combating the growth in antimicrobial resistance. Limited access, largely driven by prohibitive costs, to sophisticated laboratory techniques and newer pharmacological agents, leaves the implementation of effective infection prevention and control and antimicrobial stewardship programmes as the most pragmatic options to address the problem.

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Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU

Saggers,

Mothibi,

Irwin

et al. 2023

Curr Infect Dis Rep

View full text Add to dashboard Cite

show abstract

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Pediatric Infections in the Intensive Care Unit (ICU)

Cited by 1 publication

References 50 publications

Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU

Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU

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