Pediatric Hypovitaminosis D

Ariganjoye, Rafiu

doi:10.1177/2333794x16685504

Cited by 20 publications

(13 citation statements)

References 39 publications

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“…In all age groups, a severe vitamin D deficiency is related to bone pain of various intensity and localization (predominantly in the lower limbs and feet) as well as increased susceptibility to bone fractures. Advanced stages of nutritional rickets and osteomalacia may be even the life-threatening conditions, characterized not only by bone deformations, but also by hypocalcemic seizures ( 29 , 30 ), tetany ( 31 , 32 ), severe bone pain and significant muscle weakness ( 33 , 34 ), hypocalcemic cardiomiopathy, even resulting in circulatory failure ( 35 – 38 ), and by disorders of psychomotor and physical development ( 39 ), including short stature ( 4 , 40 ).…”

Section: Evidence Base For Updated Polish Recommendationsmentioning

confidence: 99%

Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland—Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies—2018 Update

et al. 2018

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IntroductionVitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professionals in Poland, an updated recommendation for the prevention, diagnosis and treatment of vitamin D deficiency.MethodsA systematic literature search examining the prevention and treatment strategies for vitamin D deficiency was conducted. Updated recommendations were developed using the Grading of Recommendations, Assessment, Development and Evaluation system describing the strength of the recommendation and the quality of supporting evidence. Twenty-seven contributors representing different areas of expertise and medical specialties, including pediatricians, geriatricians, endocrinologists, epidemiologists, nephrologists, gynecologists and obstetricians evaluated the available published evidence related to vitamin D, formulated the goals of this document and developed a common consolidated position. The consensus group, representing six national specialist consultants and eight Polish and international scientific organizations/societies, participated in the process of grading evidence and drawing up the general and specific recommendations.ResultsThe updated recommendations define the diagnostic criteria for the evaluation of vitamin D status and describe the prevention and treatment strategies of vitamin D deficiency in the general population and in groups at increased risk of the deficiency. Age- and weight-specific recommendations for prevention, supplementation and treatment of vitamin D deficiency are presented, and detailed practice guidance is discussed regarding the management in primary and specialized health care.ConclusionVitamin D deficiency remains still highly prevalent in Poland, in all age groups. Currently, there is a great necessity to implement a regular supplementation with recommended doses and to develop an effective strategy to alleviate vitamin D deficiency in the population. These updated recommendations are addressed to health professionals and the authorities pursuing comprehensive health policies and should also be included in public health programs aimed at preventing a broad spectrum of chronic diseases.

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Section: Evidence Base For Updated Polish Recommendationsmentioning

confidence: 99%

Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland—Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies—2018 Update

et al. 2018

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“…If nutritional rickets is suspected, biochemical evaluation is also recommended [10]. Serum 25(OH)D, PTH, ALP, Ca, and Pi level dosage are helpful to confirm the diagnosis and also to differentiate nutritional rickets to other causes of rickets (see Table 1) [8,[97][98][99]. Most children with vitamin D deficiency rickets have serum 25(OH)D concentrations less than 10 ng/mL and usually less than 5 ng/mL [73].…”

Section: Calcipenic Rickets 91 Nutritional Ricketsmentioning

confidence: 99%

Rickets in Children: An Update

Gentile

Chiarelli

2021

Biomedicines

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Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly affecting longer bones. Despite the fact that preventive measures are available, it is still a common disease worldwide; nutritional rickets, due to vitamin D deficiency or dietary calcium inadequate intake, remains the most common form. Medical history, physical examination, radiologic features and biochemical tests are essential for diagnosis. Although recent studies suggest hypophosphatemia as the leading alteration, rickets is classically divided into two categories: calcipenic rickets and phosphopenic rickets. Knowledge of this categorization and of respective clinical and laboratory features is essential for rapid diagnosis and correct management. The aim of this review is to analyze the epidemiological, pathogenetic, clinical, and therapeutic aspects of the different forms of rickets, describing the novelties on this “long-lived” disease.

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“…Vitamin D Deficiency of vitamin D has been observed in adolescent idiopathic scoliosis (AIS) as it affects the regulation of bone mineral density, postural control and fibrosis [165]. Pectus excavatum, a skeletal feature of rickets, is related to hypovitaminosis D, as this vitamin is essential for maintenance of healthy bones [166]. The development of lungs is also affected by the vitamin D level and deficiency of this vitamin may lead to deficits in lung function and volume [167].…”

Section: (H) Vitamin and Trace Elements Deficienciesmentioning

confidence: 99%

Pulmonary non-tuberculous mycobacterial infections: current state and future management

Chin

Sarmiento

Alvarez-Cabrera

et al. 2019

Eur J Clin Microbiol Infect Dis

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Currently, there is a trend of increasing incidence in pulmonary non-tuberculous mycobacterial infections (PNTM) together with a decrease in tuberculosis (TB) incidence, particularly in developed countries. The prevalence of PNTM in underdeveloped and developing countries remains unclear as there is still a lack of detection methods that could clearly diagnose PNTM applicable in these low-resource settings. Since non-tuberculous mycobacteria (NTM) are environmental pathogens, the vicinity favouring host-pathogen interactions is known as important predisposing factor for PNTM. The ongoing changes in world population, as well as socio-political and economic factors, are linked to the rise in the incidence of PNTM. Development is an important factor for the improvement of population well-being, but it has also been linked, in general, to detrimental environmental consequences, including the rise of emergent (usually neglected) infectious diseases, such as PNTM. The rise of neglected PNTM infections requires the expansion of the current efforts on the development of diagnostics, therapies and vaccines for mycobacterial diseases, which at present, are mainly focused on TB. This review discuss the current situation of PNTM and its predisposing factors, as well as the efforts and challenges for their control.

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Pediatric Hypovitaminosis D

Cited by 20 publications

References 39 publications

Rickets in Children: An Update

Pulmonary non-tuberculous mycobacterial infections: current state and future management

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