Pediatric hepatic rhabdoid tumor: A rare cause of abdominal mass in children

Kapral, Nicole; Melmer, Patrick D; Druzgal, Colleen; Lancaster, Luke

doi:10.1016/j.radcr.2018.03.017

Cited by 6 publications

(11 citation statements)

References 8 publications

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“…showed relatively T2 hyperintense mass with a hemorrhage into the cystic component. The solid component of the mass was T1 hypointense and postcontrast images showed heterogeneous enhancement while the cystic component showed rim enhancement [11] .…”

Section: Discussionmentioning

confidence: 94%

Malignant rhabdoid tumor—The great mimicker: Two case reports

Dasic

Sofija

Polina

et al. 2021

Radiology Case Reports

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Malignant rhabdoid tumors (MRT) represent a very rare group of tumors in infants that have an aggressive clinical behavior, are refractory to therapy, and have a high mortality rate. We present two cases that demonstrate the importance of early diagnosis for further treatment. The first case was a 4 and a half month old boy that presented with an enlarged liver and was treated as hepatoblastoma with metastatic changes in the lung parenchyma after the diagnosis. The second case was a female neonate presenting with hardening on the right side of the abdomen which was treated as MRT of the liver after radiological and clinical evaluation. In both cases, the initial histopathologic diagnosis was hepatoblastoma, but later analyses confirmed the diagnosis of MRT. From our experience, imaging findings can be a valuable tool in directing further evaluation since even histopathologic differentiation from the small cell undifferentiated hepatoblastoma is a real challenge.

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Section: Discussionmentioning

confidence: 94%

Malignant rhabdoid tumor—The great mimicker: Two case reports

Dasic

Sofija

Polina

et al. 2021

Radiology Case Reports

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show abstract

“…Extrarenal MRT are much more rare, with the liver being the fourth most common site [ 50 ]. They are most commonly diagnosed in infants and toddlers with the incidence estimated to be 0.6 per 1 million people, with a median age of 11–18 months for the extrarenal subtypes [ 51 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…Hepatic MRT frequently presents with fever, abdominal distension, abdominal pain, decreased oral intake, and emesis associated with a right upper quadrant mass or hepatomegaly [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. Patients may present with leukocytosis, anemia, transaminitis, elevated LDH with normal to mildly elevated AFP.…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…Initial imaging with ultrasound most commonly reveals a heterogenous solid mass, which may have cystic components [ 51 , 52 , 54 , 55 , 56 , 60 , 61 ]. CT and MRI imaging typically reveal hypodense areas on contrast-enhanced CT and hyperintense areas on MRI T2-weighted images [ 50 , 55 , 57 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…CT and MRI imaging typically reveal hypodense areas on contrast-enhanced CT and hyperintense areas on MRI T2-weighted images [ 50 , 55 , 57 ]. In addition, there may be areas of necrosis and fluid levels suggestive of hemorrhage [ 51 , 57 ]. Calcifications are less common than in hepatoblastoma.…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

See 2 more Smart Citations

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

2021

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The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups.

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Decoding the rhabdoid riddle in liver: A rare case of primary hepatic malignant rhabdoid tumor with a comprehensive literature review

Kerkar,

Gupta,

Azeez

et al. 2023

Diagnostic Cytopathology

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Malignant rhabdoid tumor of the liver is a rare, highly aggressive primary hepatic malignancy occurring primarily in infants. Establishing a definitive diagnosis is challenging due to its rarity, non‐specific clinicoradiologic findings, and overlapping morphologic features. Herein, we present the cytomorphologic and immunocytochemical characteristics of a rare case of primary hepatic Malignant rhabdoid tumor (MRT) in an infant. A 5‐month‐old female child presented with progressively increasing firm mass in the upper abdomen, progressive pallor, sudden onset respiratory distress, and difficulty feeding. On examination, the child had massive, firm nodular hepatomegaly. Ultrasonography of the abdomen revealed a heterogeneously hypoechoic lesion in the left lobe of the liver. Serum alpha‐fetoprotein levels were within normal limits. An ultrasound‐guided fine‐needle aspiration cytology (FNAC) from the liver mass showed predominantly dispersed large, markedly pleomorphic tumor cells with round to oval eccentrically placed nuclei, prominent nucleoli, and moderate cytoplasm. On immunocytochemistry, tumor cells showed positivity for vimentin, cytokeratin, and EMA and demonstrated a loss of INI1, confirming the diagnosis of MRT. The index report highlights the distinctive clinicopathological features of a hepatic malignant rhabdoid tumor along with the key differential diagnoses, which may pose a diagnostic conundrum. A high index of clinical suspicion and a thorough understanding of its cytomorphological and immunochemical characteristics are crucial for an accurate diagnosis.

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Pediatric hepatic rhabdoid tumor: A rare cause of abdominal mass in children

Cited by 6 publications

References 8 publications

Malignant rhabdoid tumor—The great mimicker: Two case reports

Malignant rhabdoid tumor—The great mimicker: Two case reports

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

Decoding the rhabdoid riddle in liver: A rare case of primary hepatic malignant rhabdoid tumor with a comprehensive literature review

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