Pediatric hematology oncology during SARS‐CoV‐2: A brief communication of 28 patients and changes in clinical practice from a single institute in Pakistan

Sajid, Mir Ibrahim; Altaf, Sadaf; Mushtaq, Naureen; Belgaumi, Asim; Fadoo, Zehra

doi:10.1002/pbc.28527

Cited by 6 publications

(10 citation statements)

References 4 publications

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“…The reorganization of hospital services were reported to have mixed results ( 21 , 59 , 64 ). Ganguly et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2021) also noted a reorganization of pandemic services in a single healthcare institution in Pakistan; however, to more negative results ( 64 ). The authors noted that due to shared inpatient space, any child suspected of being exposed to a healthcare provider with suspected COVID-19 would lead to a cascade of exposed children with multiple children requiring isolation and testing ( 64 ). Testing every febrile neutropenic patient with COVID-19 led to undue healthcare expenditures for most self-paying families.…”

Section: Resultsmentioning

confidence: 99%

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The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

et al. 2022

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BackgroundChildhood cancer represents a leading cause of death and disease burden in high income countries (HICs) and low-and-middle income countries (LMICs). It is postulated that the current COVID-19 pandemic has hampered global development of pediatric oncology care programs. This systematic review aimed to comprehensively review the global impact of COVID-19 on childhood cancer clinical outcomes and care delivery.MethodsA systematic search was conducted on PubMed, Embase, Medline, and the African Medical Index from inception to November 3, 2021 following PRISMA guidelines. A manual search was performed to identify additional relevant studies. Articles were selected based on predetermined eligibility criteria.FindingsThe majority of studies reported patients with cancer and COVID-19 presenting as asymptomatic (HICs: 33.7%, LMICs: 22.0%) or with primary manifestations of fever (HICs: 36.1%, LMICs: 51.4%) and respiratory symptoms (HICs: 29.6%, LMICs: 11.7%). LMICs also reported a high frequency of patients presenting with cough (23.6%) and gastrointestinal symptoms (10.6%). The majority of patients were generally noted to have a good prognosis; however the crude mortality rate was higher in LMICs when compared to HICs (8.0% vs 1.8%). Moreover, the pandemic has resulted in delays and interruptions to cancer therapies and delays in childhood cancer diagnoses in both HICs and LMICs. However, these findings were disproportionately reported in LMICs, with significant staff shortages, supply chain disruptions, and limited access to cancer therapies for patients.ConclusionsThe COVID-19 pandemic has resulted in delays and interruptions to childhood cancer therapies and delays in childhood cancer diagnoses, and disproportionately so within LMICs. This review provides lessons learned for future system-wide disruptions to care, as well as provides key points for moving forward better with care through the remainder of this pandemic.Systematic Review RegistrationCRD42021266758, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=266758

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“…The reorganization of hospital services were reported to have mixed results ( 21 , 59 , 64 ). Ganguly et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

et al. 2022

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“…Contudo, em contraste com os adultos, a maioria das crianças infectadas pelo coronavírus demonstraram um curso mais tranquilizador e com melhores resultados aos tratamentos (Patel, 2020). Entre as condutas da equipe de saúde, nos casos de diagnóstico positivo para coronavírus, opta-se por tratamento, como a internação em UTI, considerando que os resultados são mais favoráveis (Heilbronner et al, 2020;Sajid, Altaf, Mushtaq, Belgaumi, & Fadoo, 2020). Drogas antipiréticas são a base da terapia para crianças com quadro leve e, em casos de dificuldade respiratória, beneficiam-se de oxigênio nasal ou ventilação mecânica invasiva (De Luca et al, 2020), além do uso de medicações como a hidroxicloroquina, lopinavir, ritonavir, teicoplanina e remdesivir (Sieni et al, 2020;De Luca et al, 2020).…”

Section: Discussionunclassified

“…8, 33 e 43) (De Rojas et al, 2020;Minotti, Tirelli, Barbieri, Giaquinto, & Donà, 2020;Schied, Trovillion, & Moodley, 2020). Já as crianças que realizam quimioterapia para tratamento de tumores hematológicos e sólidos, em determinados casos, necessitam interromper ou atrasar o tratamento (De Rojas et al, 2020;Baruchel et al, 2020;He, Lin, Tang, Yang, Wang, & Yang, 2020;Yang, Li, & Wang, 2020;Turner et al, 2020;Sajid, Altaf, Mushtaq, Belgaumi, & Fadoo, 2020), sendo importante retomar, o mais breve possível, o tratamento (De Rojas et al, 2020;Sieni et al, 2020). Recomenda-se testar o SARS-CoV-2 antes de iniciar a quimioterapia em paciente com ou sem sintomas e, quando positivo, sugere-se atrasar o tratamento oncológico (Baruchel et al, 2020;Sieni et al, 2020;Sajid, Altaf, Mushtaq, Belgaumi, & Fadoo, 2020).…”

Section: Discussionunclassified

“…10748 pacientes de alto risco para infecção de COVID-19 leva à testagem completa e repetidas vezes, inclusive em pacientes assintomáticos (De Rojas et al, 2020;Verdú-Amorós et al, 2020). Mesmo com a necessidade de hospitalização, apresentaram resultados favoráveis ao tratamento do vírus e, nesses casos, a hidroxicloroquina foi a droga mais frequentemente usada (De Rojas et al, 2020;Sajid, Altaf, Mushtaq, Belgaumi, & Fadoo, 2020). Em um caso relatadouma menina de seis anos em tratamento para linfoma linfoblástico B e que positivou para coronavírus -, o tratamento foi apenas para cuidados de suporte, sem receber terapia antirretroviral experimental ou imunoglobulina intravenosa (Schied, Trovillio, & Moodley, 2020).…”

Section: Discussionunclassified

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A COVID-19 e as crianças com doenças crônicas: revisão de escopo

Antunes

Kinalski

Schneider

et al. 2020

RSD

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Diante do cenário da pandemia por coronavírus, que assola o mundo desde o final de 2019, ainda são muitas as incertezas que envolvem essa doença, COVID-19, e o público pediátrico, principalmente as crianças portadoras de doenças crônicas. Considerando essa realidade, o objetivo deste artigo é conhecer as publicações científicas sobre COVID-19 em crianças com doenças crônicas. Trata-se de um estudo de revisão sistematizada da literatura do tipo Scoping Reviews. A busca foi realizada nos meses de maio de 2020 a agosto de 2020, nas bases eletrônicas de dados SciVerse Scopus, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Public MEDLINE, Current Nursing and Allied Health Literature e Embase, e totalizaram 5.570 produções científicas. A amostra final foi composta por 46 artigos na íntegra, que tiveram os conteúdos extraídos por categorias conceituais: suscetibilidade/fatores de risco; manifestações clínicas; hospitalização; estratégias de cuidado e medidas preventivas em relação à COVID-19 em crianças com doenças crônicas. A pesquisa permite concluir que crianças com doenças crônicas representam um grupo da população que pode apresentar um risco aumentado para complicações da COVID-19. Contudo, os estudos analisados demonstram que não há motivos para suspender o tratamento de crianças com doenças crônicas durante a pandemia e que é fundamental avaliar o risco versus o benefício de iniciar ou manter o tratamento em casos de crianças confirmadas para COVID-19.

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How a pediatric neuro-oncology unit was managed in Madrid during the first wave of the COVID-19 pandemic

Vila

Vázquez-Gómez

Fioravantti

et al. 2021

Tumori

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Introduction: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, infection prevention measures were enforced at our Pediatric Neuro-Oncology unit. Methods: A retrospective study analyzing patients booked in this unit during lockdown was performed to describe its performance. Results: There were 438 consultations for 123 patients (320 on-site/118 telephone). Eight new diagnoses were made, with one significant delay. Only one patient tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Delay in imaging testing occurred in 15 patients. Chemotherapy was delayed in one case. There were no delays in radiotherapy. Conclusions: Measures implemented were effective in minimizing the risk of COVID-19 infection, achieving continuity in diagnoses and treatment, and avoiding delays that could impact survival.

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Pediatric hematology oncology during SARS‐CoV‐2: A brief communication of 28 patients and changes in clinical practice from a single institute in Pakistan

Cited by 6 publications

References 4 publications

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

A COVID-19 e as crianças com doenças crônicas: revisão de escopo

How a pediatric neuro-oncology unit was managed in Madrid during the first wave of the COVID-19 pandemic

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