Pediatric Head and Neck Malignancies

Qaisi, Mohammed; Eid, Issam

doi:10.1016/j.coms.2015.07.008

Cited by 27 publications

(8 citation statements)

References 49 publications

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“…Rhabdomyosarcoma has been demonstrated to have the worst prognosis of all head and neck sarcomas, and the head and neck is the most common site of rhabdomyosarcoma overall . We observed a similar trend in our data, wherein patients with rhabdomyosarcoma survived for an average of 30 months and a those with non‐rhabdomyosarcoma tumors showed a mean survival of 40 months.…”

Section: Discussionsupporting

confidence: 85%

“…7 Rhabdomyosarcoma has been demonstrated to have the worst prognosis of all head and neck sarcomas, and the head and neck is the most common site of rhabdomyosarcoma overall. 2,4,16 We observed a similar trend in our data, wherein patients with rhabdomyosarcoma survived for an average of 30 months and a those with nonrhabdomyosarcoma tumors showed a mean survival of 40 months. No other tumor histologies were found to have significantly worse survival, but the study of individual histological types was limited by the rarity of this disease and small sample sizes.…”

Section: Survivalsupporting

confidence: 85%

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Sarcomas of the paranasal sinuses: An analysis of the SEER database

Martin

Radomski

Harley

2019

Laryngoscope Investig Oto

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Objective To determine the demographics, treatment modalities, and overall survival of patients with sinonasal sarcoma. Methods All cases of primary sinonasal sarcomas diagnosed between the years of 2009 and 2014 were extracted from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Additional variables collected included age, gender, ethnicity, tumor histological subtype, tumor size, treatment modality, vitality status, and follow‐up time. Kaplan‐Meier survival curves were generated and overall survival was calculated. Results One hundred and four cases of sinonasal sarcoma were identified. The majority of patients were female (55%), white (76%), and non‐Hispanic (84%), and the mean age was 47 ± 22 years. The most common tumor sites were the maxillary sinus, followed by the ethmoid, sphenoid, and frontal sinus. Forty six percent of tumors were rhabdomyosarcoma type. Most patients (66%) had some type of surgery, 64% received radiation, and 58% received chemotherapy as part of their treatment. Overall 1‐ and 5‐year survival was 79% and 31%, respectively. There was no significant difference in survival based on patient gender, age, ethnicity, radiation, or chemotherapy treatment. Conclusions This study adds to the current literature of sinonasal sarcomas and is the first to report in detail the surgical interventions performed as well as characteristics about lymph node spread, tumor histology, and treatment outcomes since the advent of radiation and chemotherapy. As these tumors are so rare, continued study of the demographics, tumor characteristics, and long‐term outcomes of this population is necessary to guide treatment modalities and strategies for otolaryngologists. Level of Evidence 2b

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Section: Discussionsupporting

confidence: 85%

Section: Survivalsupporting

confidence: 85%

Sarcomas of the paranasal sinuses: An analysis of the SEER database

Martin

Radomski

Harley

2019

Laryngoscope Investig Oto

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“…Cervical tumors are rarely malignant in children [2][3][4]. Rhabdomyosarcoma is the most frequently encountered [2][3][4][5] (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Cervical ultrasound, CT scan, and MRI play an important role in diagnosis orientations (Table 2) [3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis difficulty of histiocytosis in the thyroid region of a child: a rare case report with literature review of differential diagnoses

Benhoummad

Cherrabi

Imdary

2022

Egypt J Otolaryngol

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Background Isolated histiocytosis of thyroid region is very rare; clinical history, exam, and radiological aspects are non-specific, and etiological reasoning is quite difficult considering the tremendous number of differential diagnoses. Case presentation This is the case of a 6-year-old girl who came to the emergency room with an acute presentation bulging of the anterior and left lateral regions of the neck. The palpation of the mass showed tenderness; there was no sign of inflammation, nor was there any fistula to the anterior border of the sternocleidomastoid muscle. The patient was stable. She did not have any signs of compression. The initial blood showed anemia and inflammatory syndrome. She underwent cervical ultrasound exam that showed a mass at the expense of the left thyroid lobe; the mass extends through the sub-hyoid muscles to the lateral cervical region. A CT scan with and without contrast injection was performed. It showed a heterogenous mass, which seemed centered in the anterior compartment, and from which it extended to the left lateral compartment, as well as the posterior compartment, invading the prevertebral muscles and englobing the carotid and the internal jugular vein. The patient underwent surgical biopsy. A basal cervical incision was made, dissection with the myo-cutaneous plane. Per-operative observation established that the mass breeched the infrahyoid muscles, as well as the sternocleidomastoid muscle. A biopsy was performed without opening the middle line. The pathological exam showed an eosinophilic granulomatosis, associated with Stembergoid cells. The immune-histochemical exam concluded that the lesion is histiocytosis. The patient underwent a cervicothoracic and pelvic CT scan to rule out systemic forms. The diagnosis of isolated histiocytosis of thyroid region was confirmed. The patient underwent hemithyroidectomy, associated with careful dissection of extension of the mass to lateral compartment of the neck. Postoperative exam showed no abnormalities. No dysphonia and no hypocalcemia were observed. The 8-month follow-up showed satisfactory results, no cervical swelling, and no signs of inflammation or compression. Postoperative naso-fibroscopy was normal. Conclusions The most important takeaway message of this work is that methodical approach of neck masses allows to rule out the most aggressive lesions frequently encountered, which allows clinicians to establish thorough diagnosis and management without further delay.

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“…El objetivo de estos protocolos, es lograr que con el tratamiento quirúrgico definitivo se evite al máxi-mo la utilización de quimioterapia o radioterapia, a fin de disminuir sus efectos adversos y complicaciones a largo plazo (Qaisi & Eid, 2016). Actualmente, se espera que con este protocolo un 80 % de los niños diagnosticados con esta neoplasia maligna se curen de su enfermedad (Hicks & Flaitz).…”

Section: Tumores De La Musculatura Lisa: Leiomiosarcomaunclassified

Cáncer Bucomaxilofacial en Niños III: Tumores Malignos del Tejido Blando

Fernández

Becerra²,

Rehbein³

et al. 2017

Int. J. Odontostomat.

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Odontostomat., 11(4):387-392, 2017. RESUMEN:El grupo de neoplasias malignas de tejido blando de la región de cabeza y cuello en pacientes pediátricos está representado por carcinomas, sarcomas, melanomas y tumores de diferenciación incierta. La neoplasia más prevalente en la población pediátrica es el Rabdomiosarcoma, seguido por el carcinoma de células escamosas. Los rangos de presentación son muy amplios, siendo los grupos entre 2-6 años y 15-19 años los que presentan mayor incidencia. Se ha planteado que la etiología de estas neoplasias es incierta. El tratamiento de estas neoplasias es comúnmente de enfoque multimodal, combinando un procedimiento quirúrgico con quimioterapia y radioterapia. El pronóstico y sobrevida del paciente dependerán principalmente del momento en que se realice el diagnóstico de la lesión. Un diagnóstico y tratamiento temprano favorecen las posibilidades de sobrevida y el pronóstico del paciente. Este estudio corresponde a la 3ra parte de "Cáncer bucomaxilofacial en niños". Se hará referencia a los distintos tumores malignos del tejido blando en la población pediátrica en el territorio de cabeza y cuello, abarcando sus generalidades, etiología, epidemiología, tratamiento y pronóstico.PALABRAS CLAVE: cáncer oral, niño, maxilares, mandíbula, mucosa bucal, neoplasias maxilomandibulares. INTRODUCCIÓNEntre los diferentes tipos de neoplasias que se desarrollan en la población pediátrica a nivel de cabeza y cuello, el grupo de las neoplasias malignas de tejido blando está representado por carcinomas, sarcomas, melanomas y tumores de diferenciación incierta. En la Tabla I se observa la clasificación de las neoplasias malignas de tejidos blandos basado en la Es considerado que la presencia de carcinomas, a diferencia de los adultos, son poco frecuente en este grupo y en caso de presentarse, generalmente ocurre a nivel nasofaríngeo y se detecta más bien por metástasis en linfonodos cervicales (Santander, 2013).El grupo de los sarcomas representa entre un 5-15 % de las neoplasias malignas pediátricas, siendo el grupo de rabdomiosarcomas de cabeza y cuello el más común de estos (Divyambika et al., 2012). Según las estadísticas del programa de cáncer infantil en Chile (PINDA), la distribución porcentual de los sarcomas de partes blandas en la infancia corresponden al 6 % de las neoplasias malignas pediátricas y se presentan con mayor frecuencia en pacientes de sexo masculino. Según el MINSAL (2011), el rango de presentación varía entre los primeros días de vida hasta los 19 años de edad, donde la mayor incidencia es entre los grupos de 2 a 6 años y de 15 a 19 años de edad. En general, la edad de presentación de los sarcomas de partes blandas pediátricos es entre los 5-10 años de edad. Según el MINSAL la sobrevida del paciente dependerá del tamaño del tumor. Si este es menor a 5 cm, la sobrevida alcanza a un 81 %, por el contrario si es mayor a 5 cm la sobrevida disminuye drásticamente a un 16 %. Cabe destacar que si la detección es temprana, la probabilidad de mejoría y sobrevida es mayor (Vargas ...

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Pediatric Head and Neck Malignancies

Cited by 27 publications

References 49 publications

Sarcomas of the paranasal sinuses: An analysis of the SEER database

Sarcomas of the paranasal sinuses: An analysis of the SEER database

Diagnosis difficulty of histiocytosis in the thyroid region of a child: a rare case report with literature review of differential diagnoses

Cáncer Bucomaxilofacial en Niños III: Tumores Malignos del Tejido Blando

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