Pediatric glioblastoma: clinico-radiological profile and factors affecting the outcome

Das, Kuntal Kanti; Mehrotra, Anant; Nair, Anup; Kumar, Shaleen; Srivastava, Arun Kumar; Sahu, Rabi Narayan; Kumar, Raj

doi:10.1007/s00381-012-1890-x

Cited by 55 publications

(65 citation statements)

References 30 publications

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“…In contrast, GBM accounts for no more than 3-15% of primary central nervous system (CNS) tumors in children (2)(3)(4)(5)(6)(7). This is despite the fact that CNS tumors are the most common solid tumors of childhood, and 40-50% of these tumors are constituted by the astrocytomas (8).…”

Section: Introductionmentioning

confidence: 81%

“…Nevertheless, GBM remains an equally devastating disease in children with substantial morbidity and mortality. The reported median survival in p-GBM ranges from 13 to 73 months with a 5-year survival of less than 20% (2,4,6,(9)(10)(11)(12)(13). A few reports, however, reveal a relatively better prognosis and long-term survival figures in p-GBM as compared with adults (4,(9)(10)(11).…”

Section: Introductionmentioning

confidence: 97%

“…In fact, no such standard exists in children although a similar management policy is employed by most neurosurgeons across the globe. While there is sufficient evidence for the prognostic impact of maximal surgical excision of the visible tumor mass (4,9,10,14), the concerns of irradiation on the developing brain and contradictory results of various chemotherapy regimens in p-GBM make the treatment decisions rather complicated and difficult in children.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Glioblastoma

Das¹,

Kumar²

2017

Glioblastoma

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Glioblastoma in children, when compared with adults, is relatively rare. Despite this rarity, it is apparent from the limited number of publications that pediatric glioblastoma is quite distinct from their adult counterparts. The differences pertain to the molecular genetics, effectiveness of the adjuvant therapies, and possibly the prognosis after treatment. With a plethora of path-breaking translational research coming through in recent times, a host of new information is now available on pediatric glioblastomas that holds great promise as far as the future treatment options are concerned. This chapter is an attempt to highlight the key clinical aspects of pediatric glioblastoma in the light of the emerging clinical and laboratory evidence.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Pediatric Glioblastoma

Das¹,

Kumar²

2017

Glioblastoma

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“…It makes Indonesia becomes the first rank in the Southeastern Asia. Therefore, the need for more effective novel treatments for this disease is very urgent [3]. The Boron Neutron Capture Therapy (BNCT) can be a possible solution.…”

Section: Introductionmentioning

confidence: 99%

Modeling the Radiation Shielding of Boron Neutron Capture Therapy Based on 2.4 Mev D-D Neutron Generator Facility

Mu’Alim¹,

Sardjono²

2018

Tri Dasa Mega

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MODELING THE RADIATION SHIELDING OF BORON NEUTRON CAPTURE THERAPY BASED ON 2.4 MEV D-D NEUTRON GENERATOR FACILITY. Radiation shield at BoronNeutron Capture Therapy (BNCT) facility based on D-D Neutron Generator 2.4 MeV has been modified with pre-designed beam shaping assembly (BSA). Modeling includes the material and thickness used in the radiation shield. This radiation shield is expected to protect workers from radiation doses rate that is not exceed 20 mSv·year-1 of dose limit values. The selected materials are barite, paraffin, polyethylene and lead. Calculations were performed using the MCNPX program with tally F4 to determine the dose rate coming out of the radiation shield not exceeding the radiation dose rate of 10 µSv·hr-1. Design 3 was chosen as the recommended model of the four models that have been made. The 3rd shield design uses a 100 cm thickness of barite concrete as primamary layer to surrounding 100 cm x 100 cm x 166.4 cm room, and a 40 cm borated polyethylene surrounding the barite concrete material. Then 10 cm barite concrete and 10 cm of borated polyethylene are added to reduce the primary radiation straight from the BSA after leaving the main layer. The largest dose rate was 4.58 µSv·h-1 on cell 227 and average radiation dose rate 0.65 µSv·hr-1. The dose rates are lower than the lethal dose that is allowed by BAPETEN for radiation worker lethal dose.Keywords: Radiation shield, tally, radiation dose rate, BSA, BNCT ABSTRAK PEMODELAN PERISAI RADIASI PADA FASILITAS BORON NEUTRON CAPTURE THERAPY BERBASIS GENERATOR NEUTRON D-D 2,4 MeV. Telah dimodelkan perisai radiasi pada fasilitas Boron Neutron Capture Therapy (BNCT) berbasis reaksi D-D pada Neutron Generator 2,4 MeV dengan

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“…Location GBM generally located in supratentorial areas such as frontal, temporal, parietal and occipital lobes [6,7]. The median overall survival of GBM patients with a deep location was 10 months and 24 months for GBM patients with superficial location [8]. It has been treated with various methods such as radiotherapy, chemotherapy, and surgery.…”

Section: Introductionmentioning

confidence: 99%

Calculation of BNCT Dosimetry for Brain Cancer Based on Kartini Research Reactor Using Phits Code

Ntoy

Sardjono²

2017

Tri Dasa Mega

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CALCULATION OF BNCT DOSIMETRY FOR BRAIN CANCER BASED ON KARTINI RESEARCH REACTOR USING PHITS CODE.Cancer is a dangerous disease caused by the growth of a mass of cells that are unnatural and uncontrollable. Glioblastoma, also called as glioblastoma multiforme (GBM), is one of dangerous brain cancer. The dismal prognosis associated with glioblastoma is attributable not only to its aggressive and infiltrative behavior, but also to its location typically deep in the parenchyma of the brain. In resolving this chalenge, the BNCT method can be a solution. This study aims to calculate BNCT dosimetry in different of cancer positions and irradiation geometries using PHITS code. The results show that the deeper the cancers target at brain the slower the total absorbed dose rate of cancer target. It takes a longer treatment time. Based on the treatment time and total absorbed dose rate of cancer target, the TOP irradiation geometry is an appropriate choice in treating the cancer target in this case. To achieve the histopathological cure of GBM at the primary site, the absorbed dose of brain was calculated to be 1.07 Gy and 1.64 Gy for the LLAT and PA irradiation geometry, respectively. While, for cancer position of 3 cm, 5 cm, 7.15 cm, 9 cm, and 11 cm, the absorbed dose of brain is 0.25 Gy, 0.48 Gy, 0.85 Gy, 1.33 Gy, and 2.01 Gy, respectively. In addition to the stochastic effect, it was found also deterministic effects that may be produced such as cataracts.Keywords: BNCT dosimetry; GBM; brain cancer cases; PHITS; MIRD phantom LLAT dan PA. Sedangkan, untuk posisi kanker 3 cm, 5 cm, 7,15 cm, 9 cm, dan 11 cm,25 Gy, 0,48 Gy, 0,85 Gy, 1,33 Gy,and 2,01 Gy. Selain adanya efek stokastik, ditemukan juga efek deterministik yang mungkin dihasilkan seperti katarak. ABSTRAK PERHITUNGAN DOSIMETRI BNCT PADA KANKER OTAK BERBASIS REAKTOR RISET KARTINI MENGGUNAKAN PROGRAM PHITS. Kanker merupakansalahsatu penyakit berbahaya yang diakibatkan oleh tumbuhnya sekumpulan massa sel-sel yang tidak wajar dan tidak terkendali. Salah satu penyakit kanker otak yang berbahaya adalah Glioblastoma atau yang biasa disebut Glioblastoma Multiforme (GBM). Prognosis suram terkait dengan GBM tidak hanya untuk perilaku agresif dan infiltrasi, tetapi juga terhadaplokasi yang jauh di dalam parenkim otak. Untuk menjawab hal tersebut,

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Pediatric glioblastoma: clinico-radiological profile and factors affecting the outcome

Abstract: Pediatric glioblastomas are associated with longer progression-free as well as overall survivals. Extent of tumor resection is the strongest predictor of survival in pediatric glioblastoma. Hence, an aggressive surgical resection may fetch a better outcome in children with glioblastoma.

Cited by 55 publications

References 30 publications

Pediatric Glioblastoma

Pediatric Glioblastoma

Modeling the Radiation Shielding of Boron Neutron Capture Therapy Based on 2.4 Mev D-D Neutron Generator Facility

Calculation of BNCT Dosimetry for Brain Cancer Based on Kartini Research Reactor Using Phits Code

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