Pediatric Glaucoma

Penetration Enhancers in Ocular Drug Delivery

“…This fluid is formed and delivered to the posterior chamber by nonpigmented cells of the epithelia via ciliary processes [34]. Then, it flows through the pupil into the anterior chamber where two ways of outflow are found (Figure 5): (1) the conventional route is the primary outflow, where the aqueous humor is drained through the trabecular meshwork located at the anterior chamber angle (iridocorneal angle) to the Schlemm’s canal (circular tube located in the limbus, 1-mm-wide region of merging epithelium of cornea and sclera), which delivers it directly into aqueous veins [35]; (2) uveoscleral outflow is provided by means of the iris root and the ciliary body face, where the aqueous humor crosses between fibers of the muscle into the supraciliary and suprachoroidal spaces and is collected by the choroidal blood circulation. The proportion of aqueous outflow via each route could be different according to the age and disease [36].…”