Pediatric Fever of Unknown Origin

Antoon, James W.; Potisek, Nicholas M.; Lohr, Jacob A.

doi:10.1542/pir.36-9-380

Cited by 35 publications

(46 citation statements)

References 43 publications

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“…6 Over the past 3 decades, the fever length and height required for a diagnosis of FUO have changed. 1 Despite our study definition of FUO as a temperature of 38.0°C for .7 days, we did not find a large variation in the causes FUO compared with studies with a FUO duration of 2 or even 3 weeks (Fig 1). It is notable that the causes of FUO have not markedly shifted despite decreasing the required fever, height, and duration.…”

Section: -4contrasting

confidence: 53%

“…For study purposes, FUO was defined as fever of 38.0°C or greater for .7-days duration without an identifiable source on presentation to the hospital. 1 Inclusion criteria were defined as an International Classification of Diseases, Ninth Revision diagnosis of fever (780.60 or 780.61). A chart review was then performed to evaluate for additional inclusion criteria including fever defined as FUO above and an evaluation by a medical provider during the period of fever.…”

Section: Methodsmentioning

confidence: 99%

“…The cohort categories chosen were similar to those in previously published studies. 1,[5][6][7]9 Cohorting patients by duration of fever and etiologic category allowed us to determine if duration of fever in the definition of FUO was associated with changes in underlying FUO categories.…”

Section: Patient Populationmentioning

confidence: 99%

“…The causes of FUO are broad, and common etiologies include infectious, collagen-inflammatory (autoimmune), oncologic, neurologic, genetic or congenital, pharmacologic, miscellaneous, and iatrogenic diseases. 1 Although the etiologies of FUO have been extensively studied in adults, there is limited literature on FUO in children. 1,2 Authors of recent studies in adults demonstrate the dynamic nature of FUO over time.…”

mentioning

confidence: 99%

“…1 Although the etiologies of FUO have been extensively studied in adults, there is limited literature on FUO in children. 1,2 Authors of recent studies in adults demonstrate the dynamic nature of FUO over time. In the past 30 years, the most common identifiable FUO etiologies in adults changed from infectious to inflammatory diseases.…”

mentioning

confidence: 99%

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Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children

Antoon

Peritz

Parsons

et al. 2018

Hospital Pediatrics

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A B S T R A C TBACKGROUND: Fever of unknown origin (FUO) is a well-known pediatric presentation. The primary studies determining the causes of prolonged fever in children were performed 4 decades ago, before major advances in laboratory and diagnostic testing. Given that the distribution of diagnosed causes of adult FUO has changed in recent decades, we hypothesized that the etiology of FUO in children has concordantly changed and also may be impacted by a definition that includes a shorter required duration of fever.

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Section: -4contrasting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Patient Populationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children

Antoon

Peritz

Parsons

et al. 2018

Hospital Pediatrics

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Anti‐N‐Methyl‐D‐aspartate receptor encephalitis masquerading as fever of unknown origin

Heng

Lee

Thomas

2021

Clinical Case Reports

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We describe a child with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis who had fever of unknown origin (FUO) without encephalopathy or behavioral change. The main neurological symptoms were tremor, truncal ataxia, and postural hypotension. Anti-NMDAR antibodies were present in serum and cerebrospinal fluid. With intravenous immunoglobulin, she made a complete recovery.Children and adolescents who have fever of unknown origin (FUO), defined as temperature more than 38 degrees Celsius for longer than 14 days, are usually prescribed empiric antimicrobial treatment while the underlying cause is being evaluated. 1 This involves obtaining a detailed travel and symptom history, a physical examination, and an array of investigations for an underlying infection, autoimmune disorder, oncologic or genetic etiology. Infections are the most common etiology, but an increasing number of noninfectious causes are now known. 2 To this list, we would add anti-Nmethyl-D-aspartate (NMDAR) receptor encephalitis.Anti-NMDAR receptor encephalitis is a devastating disease. A short prodromal febrile illness usually precedes a fairly characteristic neurological syndrome involving psychiatric symptoms or mood change, encephalopathy, movement disorder, speech or language difficulties, and seizures. Some patients have autonomic dysfunction, respiratory insufficiency, or cerebellar symptoms. 3,4 We report a patient with anti-NMDAR encephalitis who primarily had FUO without prominent neuropsychiatric symptoms or encephalopathy and had less typical disease manifestations. | CASE REPORTThis is a previously well 13-year-old girl who presented to the hospital with a 3-day history of fever, headache, dizziness,

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Whole-Body MR Imaging

Greer

2020

Pediatric Body MRI

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Pediatric Fever of Unknown Origin

Cited by 35 publications

References 43 publications

Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children

Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children

Anti‐N‐Methyl‐D‐aspartate receptor encephalitis masquerading as fever of unknown origin

Whole-Body MR Imaging

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