Pediatric Drug Eruptions of the Skin

Frieling, Gretchen W.

doi:10.1007/978-1-4471-6729-7_38

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…A few drugs can trigger localized responses due to extravasation to tissues adjoining the application zones (Heidary et al, 2008). Chemotherapy mucocutaneous responses are common and now and then not analyzed (Frieling, 2015). Clinical trials have shown varying rates of mucosa and cutis xerosis, ranging from mild to severe forms with dermatitis and crevices, from 12 percent to 35 percent.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Skin Manifestations in Patients on Chemotherapy

ULLAH¹,

SAEED

RAFIQUE³

2023

Biol Clin Sci Res J

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The study's objective was to determine the frequency of skin manifestations in patients on chemotherapy. This cross-sectional study was conducted on 170 patients on chemotherapy with post-acne scarring and hyperpigmentation not responsive to other treatments were included at the Department of Dermatology, Unit-1, Jinnah Hospital Lahore from April 2016 to September 2016. Patients of both genders and any age and on chemotherapy, at least after their first dosage, were included. Patients having skin manifestation before chemotherapy, patients with a history of HCV, those having diabetes mellitus (Fasting BSR > 100 mg/dl), andpatients having other connective tissue diseases, SLE, DLE, etc., were excluded. A dermatologic examination was performed, and biopsy, mycological and bacteriological tests were conducted if necessary. Skin manifestations were labelled. A total of 170 chemotherapy patients participated in this trial. There were 58 (34.1 percent) females and 112 (65.9%) males. Fifty-three people (31.2%) had no skin manifestations, 61 people (34.9%) had one, 40 people(23.5%) had two, and 16 people (9.4%) had three skin manifestations. A total of 75 patients (44.1%) are under the age of 30, 40 patients (23.5%) are between the ages of 31 and 45, and 55 patients (32.4%) are over the age of 45. In 2 cases, acral erythema was seen (1.2 percent ). In 21 cases, dry skin was seen (12.4 percent ). There was alopecia in 93 individuals (54.7 percent ). Sixteen patients still had the eruption (9.4 percent ). Three of the patients had acne(1.8 percent ). In 7 cases, purpura was present (4.1 percent ). In 47 cases, mucositis was found (27.6 percent ). Age and gender had no impact on the number of cutaneous manifestations. People receiving chemotherapy frequently get cutaneous symptoms. Alopecia, mucositis, and xerosis were among the most typical cutaneous signs.

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Section: Introductionmentioning

confidence: 99%

Frequency of Skin Manifestations in Patients on Chemotherapy

ULLAH¹,

SAEED

RAFIQUE³

2023

Biol Clin Sci Res J

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Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions

Güvenir

Arıkoğlu

Vezir

et al. 2019

CPD

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Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and visceral involvement are clinical features that lead to suspicion of severe adverse drug reactions. Severe cutaneous adverse drug reactions (SCARs) include Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis. Serum sickness like reactions, drug induced vasculitis and generalized bullous fixed drug eruptions are less severe clinical entities. SCARs are uncommon but associated with significant morbidity and mortality. Physician should be aware of specific red flags and danger signs to immediately identify these reactions. Immediate drug withdrawal is mandatory. Early diagnosis and appropriate treatment significantly affect the prognosis of the disease. The purpose of our review is to discuss clinical phenotypes of severe cutaneous drug hypersensitivity reactions.

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Pediatric Drug Eruptions of the Skin

Cited by 2 publications

References 52 publications

Frequency of Skin Manifestations in Patients on Chemotherapy

Frequency of Skin Manifestations in Patients on Chemotherapy

Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions

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