Pediatric COVID-19 Patients in Jeddah, Saudi Arabia: Clinical, Laboratory and Radiological Aspects

Kobeisy, Sumayyah Ahmed Nezar; Harbi, Saleh Al; Mehdawi, Raja Saleh; Bashammakh, Dina Salem

doi:10.36648/2254-609x.9.3.7

Cited by 9 publications

(17 citation statements)

References 8 publications

(10 reference statements)

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“…The laboratory findings are also in contrast with recently published reports. While we observed no lymphopenia, in contrast to its prevalence of 16% in a previous report ( 14 ), we witnessed a hitherto unreported high prevalence of neutropenia and thrombocytopenia, not described in earlier studies ( 14 , 16 , 17 ).…”

Section: Discussioncontrasting

confidence: 97%

“…The common signs or symptoms in our cohort are largely similar to previous reports, including fever, cough, and rhinitis ( 20 ). Respiratory symptoms associated with lower respiratory tract infection were less common (9.7%) than in previous reports ( 9 – 17 ), the reasons for which are not immediately obvious.…”

Section: Discussioncontrasting

confidence: 66%

“…The hospital course was uncomplicated in most patients, with a median hospital stay of 3.3 days, associated with a favorable outcome and no mortality. The shorter hospital stay we described, in comparison with previous reports ( Supplement 3 ), probably reflects the benign course as none of the affected children developed serious pulmonary or systemic complications ( 9 – 17 ). The reason for the marginal difference of this study with no severe morbidity nor mortality reported is not clear but may be multifactorial involving, alone or in combination, genetic, immunological, epidemiological, environmental, and economic factors.…”

Section: Discussionsupporting

confidence: 51%

“…We reviewed all nine primary publications that had reported ≥ 50 children with COVID-19 and compared their findings with ours ( Supplement 3 ) ( 9 – 17 ). Our study has the 2nd largest number of affected children ( n = 288) after one report on 582 children from 25 European countries ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports from many countries have been published on children with COVID-19, with most being case series with small-sized samples, except from China ( 9 – 17 ). There have been, so far, no data published from the UAE, a unique multi-ethnic society with a high prevalence of multigenerational extended families living at very close proximity to each other.…”

Section: Introductionmentioning

confidence: 99%

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Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional Study

et al. 2021

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Aim: In this retrospective single-center study, we report our experience with a cohort of children admitted to our hospital in Al Ain City, United Arab Emirates, with confirmed COVID-19. We also compare our findings to similar reports in the literature.Patients and Methods: Between 1st March and 31st May 2020, we reviewed the electronic patient medical records of all children with confirmed COVID-19 (ICD-10 code U07.1) managed in Al Ain hospital, designated as the only COVID-19 center in the city.Results: There were 288 children admitted with a confirmed diagnosis of Covid-19 during the study period (mean age 7.3 years, median 6.5, range 1 month to 16.9 years). The age-specific point prevalence was the highest under the age of 5 years (mean 2.0 per 1,000, 95% ci 1.7, 2.4) and decreased progressively to 0.6 per 1,000 (95% ci 0.4, 0.9) over the age of 14 years. Hospital admission was required for 193 (67%) children while 95 (33%) were discharged from the emergency department. Most children (n = 214, 74%) had been exposed to a family member with suspected or confirmed COVID-19 and asthma which was the most frequent comorbidity (n = 37, 13%). The most common symptoms were cough (n = 130, 45%), fever (n = 14, 4.8%), upper respiratory tract infection (n = 93, 32.3%), and lower respiratory tract infection in 28 (9.7%). None of the children presented with acute respiratory distress syndrome, neurological symptoms, sepsis, or septic shock. Neutropenia (absolute neutrophil count or ANC< 1.5 × 109/L) was observed in 10.4% and thrombocytopenia (<150 platelets × 109/L) in 72% of children. Nineteen patients (9%) had abnormal imaging studies (chest X-ray and chest computed tomography). Abnormalities were bilateral in six (43%), right-sided in seven (50%) with only one child (7%) with left-sided involvement. None of the children required invasive respiratory support, but four (1.4%) required noninvasive respiratory support. The median length of hospital stay was 3.3 days [1.9, 5.9]. There were no deaths in the hospital even in those with comorbidities.Conclusions: Our results confirm previous reports of mild illness of COVID-19 in our child population, even in those with comorbidities. The age-standardized prevalence was higher in children (<5 years) compared to young adolescents.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussioncontrasting

confidence: 66%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional Study

et al. 2021

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Clinical profile, risk factors and outcomes of pediatric COVID-19: a retrospective cohort multicentre study in Saudi Arabia

et al. 2022

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ObjectiveTo describe the risk factors, clinical profile and outcomes of COVID-19 in the paediatric population.DesignMulticentre, retrospective observational study.SettingFour tertiary hospitals in Saudi Arabia.PatientsWe recruited 390 paediatric patients aged 0–18 years who presented from March to December 2020 and tested positive for COVID-19 on PCR.Main outcome measuresWe retrospectively analysed medical records for sociodemographics, health indicators, clinical presentations, laboratory findings, clinical complications, and outcomes.ResultsThe mean participant age was 5.66±4.90 years, and the mean hospital stay was 2.17±3.48 days. Forty patients, mostly school-aged children (16, 40.00%; p=0.005) and children with comorbidities (25, 62.50%; p<0.001), received more than just supportive care. Complications were seen in 15 (3.9%) patients, bacterial infection being the most common (6, 40.00%). Patients presented with dyspnoea (OR 6.89; 95% CI 2.89 to 20.72), abnormal chest radiographs (OR 6.11; 95% CI 1.26 to 29.38), lethargy (OR 9.04; 95% CI 2.91 to 28.06) and elevated ferritin (OR 14.21; 95% CI 4.18 to 48.37) and D-dimer (OR 48.40; 95% CI 14.32 to 163.62), with higher odds of developing complications. The odds of paediatric intensive care unit (ICU) admission were higher for patients with dyspnoea (adjusted OR 4.66; 95% CI 1.24 to 17.50) and elevated white blood cell count (adjusted OR 3.54; 95% CI 1.02 to 12.30).ConclusionsCOVID-19 complications were limited among our patients. However, dyspnoea, abnormal chest radiographs, lethargy and elevated ferritin and D-dimer were associated with an increased risk of complications. Dyspnoea, leucocytosis, comorbidities and abnormal chest radiographs at presentation increased the risk of ICU admission.

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Coronavirus Disease in Children: A Single-Center Study from Western Saudi Arabia

Mosalli

Kobeisy

Al-Dajani

et al. 2021

International Journal of Pediatrics

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Introduction. Local data in Saudi Arabia regarding pediatric SARS-CoV-2 infection is limited. This study is aimed at adding insight regarding the effect of the novel coronavirus on pediatric patients by studying the presentation, laboratory parameters, and disposition of SARS-CoV-2-infected pediatric patients in one center in Jeddah, Saudi Arabia. Methodology. A retrospective study was conducted at the International Medical Center (IMC) in Jeddah, Saudi Arabia, to assess features of pediatric patients admitted with COVID-19 from April 2020 to September 2020. Results. A total of 43 patients were found to meet the study inclusion criteria. The most common presenting symptom was fever (53.5%) in study participants followed by complaints of cough, runny nose, and shortness of breath (37.2%). Lymphocytopenia was evident among 60% of those studied. Elevated C-Reactive Protein was remarkable in 24.9%. More than half of those (53.5%) studied required only supportive treatment. Conclusion. COVID-19 disease for the most part is mild in children with a varying clinical picture and nonspecific laboratory parameters. Further, large-scale national-based studies are needed to help in the early identification of pediatric cases at risk of complication due to COVID-19 infection hence providing proper and timely management, identifying population-specific disease pattern and perhaps targeted immunization.

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Pediatric COVID-19 Patients in Jeddah, Saudi Arabia: Clinical, Laboratory and Radiological Aspects

Cited by 9 publications

References 8 publications

Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional Study

Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional Study

Clinical profile, risk factors and outcomes of pediatric COVID-19: a retrospective cohort multicentre study in Saudi Arabia

Coronavirus Disease in Children: A Single-Center Study from Western Saudi Arabia

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