Pediatric Contact Dermatitis Registry Inaugural Case Data

Abstract

This US database provides multidisciplinary information on pediatric ACD, rates of PPT, and relevant RPPT reactions, validating the high rates of pediatric ACD previously reported in the literature. The registry database is the largest comprehensive collection of US-only pediatric patch test cases on which future research can be built. Continued collaboration between patients, health care providers, manufacturers, and policy makers is needed to decrease the most common allergens in pediatric consumer products.

Allergic contact cheilitis in children and improvement with patch testing

“…According to the Pediatric Contact Dermatitis Registry data from 2015 to 2016, the top 10 allergens for children (0–5 years old) include nickel (42%), balsam of peru (19%), fragrance mix I (18%), neomycin (17%), formaldehyde (15%), cocamidopropyl betaine (15%), cobalt dichloride (14%), MCI/MI (12%), propylene glycol (9%), bacitracin, bronopol, and wool alcohols (8%) 5 . These results significantly overlap those reported by a recent study of the top 10 pediatric allergens in the literature 6 .…”

Pre-emptive avoidance strategy 2016: update on pediatric contact dermatitis allergens

“…Furthermore, it was believed that 'Applying these proven allergens over and over to an infant's occluded, wet, and often dermatitic skin should assure an ongoing collection of sensitized adults with allergic contact dermatitis (ACD) that we can evaluate and help for many years' [10]. We now know that applying [these] proven allergens over and over leads to the same rates of sensitization in children as those seen in adults [3].…”

“…article, the PCDR has released its inaugural US-based pediatric patch test data [3]. Given that PCDR (2016) and NACDG [5] (2014) pediatric data [5] are independent databases, a meta-analysis of the two studies which met the prior P.E.A.S.…”

“…analysis criteria was performed. There were a total of 2,025 children patch tested, aged 7 months to 18 years (with a mean age of 11.1 years in the PCDR and 13.3 years in the NACDG) [3,5].…”

“…This was unexpected given that the adults had 30 more years of exposure to acquire sensitization, based on mean ages and demonstrates the impact of personal hygiene products and routine use items. Notably, 65% clinical relevance was found in both the PCDR and the NACDG data sets with the detection of a relevant contact allergen being identified as causing allergic contact dermatitis (ACD) [3].…”