Pediatric colonic inflammatory myofibroblastic tumor presenting as colo-colonic intussusception: A case report and review of the literature

Sherman, Jingjing; Darbinyan, Armine; Magid, Margret S.; Ong, Phat; Weissman, Barry A.; Benkov, Keith; Lipskar, Aaron M.

doi:10.1016/j.epsc.2015.07.006

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Ours is the youngest case reported so far with sigmoid IMT. According to the literature, 23 case reports of non-rectal IMTs were found, out of which only 6 cases were paediatric 8. Because of its rarity in paediatric patients, especially in infants—the natural history and biological potential of IMTs remain uncertain.…”

Section: Discussionmentioning

confidence: 99%

Infantile inflammatory myofibroblastic tumour of the sigmoid colon: a diagnostic dilemma

Kavirayani,

Pai,

Nayal

et al. 2023

BMJ Case Rep

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An inflammatory myofibroblastic tumour (IMT) is an uncommon neoplasm composed of inflammatory cells and myofibroblasts in a fibrous stroma. They are mostly seen in the lungs and rarely involve the gastrointestinal tract. An 8-month-old infant presented with a history of lower abdominal lump for 2 months. Her CT scan confirmed a large, lobulated mass in the retroperitoneum arising from the pelvis. The mass was found to be arising from the sigmoid colon on laparotomy which was excised. Histopathology showed a cellular tumour composed of spindle cells and inflammatory lymphocytic infiltrate. Immunohistochemistry revealed positive staining for anaplastic lymphoma kinase and smooth muscle actin, confirming the diagnosis of IMT. The patient is doing well at her 6-month follow-up. Ours is the youngest case of sigmoid IMT among the only other series of eight cases reported in the literature indicating its rarity.

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Section: Discussionmentioning

confidence: 99%

Infantile inflammatory myofibroblastic tumour of the sigmoid colon: a diagnostic dilemma

Kavirayani,

Pai,

Nayal

et al. 2023

BMJ Case Rep

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“…IMFT shares similar pathological findings of the desmoid tumor, leiomyoma, leiomyosarcoma, inflammatory fibroid polyp, gastrointestinal tumor, and schwannoma [ 5 ]. Inflammatory fibroid polyps are usually found in the sub-mucosal locations and constitute spindle cells, granulation tissue, and eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of Sigmoid Colon: Unusual Cause of Intestinal Obstruction

Kandhasamy¹,

Sundaramurthi²,

Vijayakumar³

et al. 2020

Cureus

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Inflammatory myofibroblastic tumors (IMFTs) are rare solid mesenchymal tumors frequently noted in children and young adults. It is characterized by variable clinicopathological and etiopathogenetic features. They are commonly reported in the lungs and occurrence in the colon is extremely rare. Here, we report a case of IMFT in the sigmoid colon confirmed histopathologically after surgical resection. A 40-year-old lady presented with abdominal pain, vomiting, and constipation for four days. On abdominal examination, there was tenderness in the left iliac fossa region with localized guarding. Contrast-enhanced computed tomography (CECT) showed a sigmoid colonic mass lesion with few enlarged perilesional lymph nodes. Colonoscopy demonstrated circumferential ulceration with irregular margin associated with luminal narrowing noted 55 cm from the anal verge and scope could not negotiate beyond, biopsies were taken. Later, the biopsy came as descriptive in nature. Hence, we proceeded for surgery and intra-operatively we have found there was circumferential thickening in the sigmoid colon for about size 8 cm of which was abutting the left lateral parietal wall. We have done sigmoid colon resection with adequate margins and postoperatively patient did well. Finally, the histopathology report suggested an IMFT sigmoid colon.

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Pediatric colonic inflammatory myofibroblastic tumor presenting as colo-colonic intussusception: A case report and review of the literature

Cited by 2 publications

References 27 publications

Infantile inflammatory myofibroblastic tumour of the sigmoid colon: a diagnostic dilemma

Infantile inflammatory myofibroblastic tumour of the sigmoid colon: a diagnostic dilemma

Inflammatory Myofibroblastic Tumor of Sigmoid Colon: Unusual Cause of Intestinal Obstruction

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