Pediatric CNS Tumors

doi:10.1007/978-3-540-87979-4

Cited by 14 publications

(4 citation statements)

References 580 publications

(923 reference statements)

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“…Based on location of craniopharyngiomas -variable vision loss, endocrine abnormalities, and/or mental disturbances can occur. The majority of signs/symptoms/morbidities that occur from craniopharyngiomas are due to space occupation/mass effect and elevated ICP (4,8,9). Various signaling pathways in human body are associated with normal cell proliferation, growth, and survival.…”

Section: Discussionmentioning

confidence: 99%

“…Endocrine abnormalities can be variable and are related to dysregulation of the hypothalamic-pituitary axis. Most complications of craniopharyngiomas are due to space occupation and rarely due to malignant transformation (4). WNT (wingless) signaling is important in normal cell proliferation and growth but it has been closely linked with carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Radiologic Response to MEK Inhibition in a Patient with a WNT-activated Craniopharyngioma

Patel

Allen

Zagzag

et al. 2020

Preprint

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Craniopharyngiomas are benign brain tumors that can often be cured surgically. A small fraction of unresectable tumors can progress and cause significant morbidity and even death. Unfortunately, WNT activated tumors lack clinically-validated targeted therapies in the pediatric population. Herein, we describe a patient with a multiply recurrent adamantinomatous craniopharyngioma with WNT activation. We utilized the MEK inhibitor binimetinib with noted interval decrease in tumor size. This demonstrates the possible utility of MEK inhibitors in WNT activated craniopharyngiomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiologic Response to MEK Inhibition in a Patient with a WNT-activated Craniopharyngioma

Patel

Allen

Zagzag

et al. 2020

Preprint

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“…Data suggests that in the pediatric population the correlation between histological WHO grade and recurrence-free and overall survival is not as strong as in adults [21]. Meningioma subtypes differ substantially between the two age groups, with high-grade tumors more prevalent in the pediatric age group [22]. A single institution review of 51 cases found approximately 10% of pediatric meningiomas were histologically consistent with the papillary subtype, WHO grade III, compared with less than 1% among adult meningiomas [6].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Intraparenchymal Meningioma: Case Report and Comparative Review

Larrew¹,

Eskandari²

2015

Pediatr Neurosurg

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Intra-axial (intraparenchymal) meningiomas are an extremely rare pathology with only dozens of cases reported. In children, the unusual characteristics of intraparenchymal meningiomas can easily create an atypical preoperative differential. The authors present the case of an otherwise healthy 14-year-old girl presenting with new-onset seizures and an intracranial lesion upon investigation. CT and MRI revealed a lesion both cystic and calcified in nature, residing completely within the brain parenchyma. Upon operative examination, the mass was found to be completely surrounded by cortex and to be of two disparate consistencies. Pathological analysis revealed the mass to be a meningioma. Despite the rarity in children, meningiomas must be kept on the differential for cystic, calcified lesions. The differential diagnosis based on imaging as well as the operative strategy taken are further discussed. In addition, the authors review the current understanding of pediatric meningiomas as compared with adult meningiomas.

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confidence: 99%