Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives

Zaky, Wafik; Finlay, Jonathan L.

doi:10.1002/pbc.27031

Cited by 28 publications

(25 citation statements)

References 51 publications

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“…Cигнальные пути, вовлеченные в патогенез ХК. Красными стрелками обозначены потенциальные терапевтические мишени [19] Signaling pathways involved at pathogenesis CPC. Red sparks indicate potential therapeutic targets [19] Российский журнал ДЕТСКОЙ ГЕМАТОЛОГИИ и ОНКОЛОГИИ R u s s i a n J o u r n a l o f P e d i a t r i c H e m a t o l o g y а n d O n c o l o g y…”

Section: нейровизуализацияunclassified

“…Y. Tong et al предположили, что ингибиторы фосфатидилинозитол 3-киназы (PI3K), подавляемые PTEN, а также mTOR-ингибиторы могут быть использованы в лечении ХК. Кроме того, авторы идентифицировали 3 онкогена, которые координируют контроль над эпигеном и репарацией ДНК при ХК, и показали, что клетки ХК in vitro были чувствительны к ATR-ингибиторам (ингибиторы пути репарации ДНК), что указывает на возможный терапевтический потенциал при ХК [19].…”

Section: новые возможности в терапииunclassified

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Choroid plexus carcinoma: review of literature

Valiakhmetova

Papusha

Yasko

et al. 2020

Ross. ž. det. gematol. onkol.

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Choroid plexus carcinoma (CPC) is a rare malignant tumor arising from the epithelium of the choroid plexus of the brain. More than 80 % of CPCs occur in children. Mutations in the TP53 gene is played the main role in the pathogenesis of these tumors. Choroid plexus carcinomas in 40 % of cases are associated with Li–Fraumeni syndrome. Survival rates in patients with CPC and Li–Fraumeni syndrome are extremely low. The standards of the therapy for patients with CPC are not defined. The extent of surgical resection and treatment modality correlate with prognosis. The role of adjuvant therapy in CPC remains unclear: doses and volumes of radiation therapy (RT), combinations of chemotherapeutic drugs, timing, and a combination of RT and chemotherapy (CT) have not been identified. Also, there is neither a standard CT regimen nor a prospective international study assessing the efficacy and toxicity of various combinations of cytostatics in patients with CPC. The article presents an overview of the existing molecular genetic changes, existing methods for the diagnosis and treatment of choroid plexus carcinoma.

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Section: нейровизуализацияunclassified

Section: новые возможности в терапииunclassified

Choroid plexus carcinoma: review of literature

Valiakhmetova

Papusha

Yasko

et al. 2020

Ross. ž. det. gematol. onkol.

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“…La incidencia promedio anual de tumores de plexo coroideo es de aproximadamente 0.3 por 1,000,000 de habitantes y el carcinoma de plexo coroideo representa menos del 1% de todos los tumores del cerebro y cerca del 20%-40% de todos los tumores de plexo coroideo (3,4) . El 65% de los carcinomas de plexo coroideo se presentan en hombres (5) . Se ha descrito que la relación hombre: mujer es de 1,2:1 (6) .…”

Section: Casos Clínicosunclassified

“…Una serie de factores contribuyen a la dificultad para obtener una resección completa, incluyendo la edad del paciente joven, el gran tamaño del tumor y la vascularización (8). Se ha demostrado que la quimioterapia, ya sea como parte de una combinación con radioterapia o como única terapia adyuvante, tiene un impacto positivo en la supervivencia (5) . }…”

Section: Casos Clínicosunclassified

Carcinoma de plexo coroideo en paciente pediátrico: Reporte de caso

Andino

Chávez

García³

2020

Act Ped Hond

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El carcinoma de plexo coroideo se considera dentro de los tumores del cerebro como uno de los más infrecuentes, presentándose principalmente en la población pediátrica con mayor incidencia en hombres. Las principales manifestaciones clínicas son secundarias a la obstrucción del flujo de líquido cefalorraquídeo. Dentro de los estudios de imagen que se pueden emplear para realizar el diagnóstico están la tomografía computarizada y la resonancia magnética sin embargo el diagnóstico definitivo es el estudio anatomopatológico. Presentamos el caso clínico de un niño de 13 años de edad que acudió a la emergencia de pediatría del Hospital Mario Catarino Rivas por cefalea de dos meses de evolución que posteriormente presentó alteración de la marcha y hemiparesia derecha. El principal objetivo de tratamiento es la resección total sin embargo no se logra en todos los casos. Se ha propuesto el uso de quimioterapia adyuvante con o sin radiación, sin embargo, aún no se ha estandarizado este enfoque.

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“…If surgery can be performed before irreversible brain damage has occurred as the result of severe hydrocephalus and/or hemorrhage, a favorable outcome can be anticipated [60]. Although surgical resection remains the most important factor for long-term survival, adjuvant therapy is required for treatment of residual, recurrent, or tumor metastases [43,48,58,67,82,84,85]. Malick et al performed a review of 284 patients (median age 2 years) from 89 studies [48].…”

Section: Treatment and Outcomementioning

confidence: 99%

Perinatal (fetal and neonatal) choroid plexus tumors: a review

Crawford

Isaacs

2019

Childs Nerv Syst

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Introduction The object of this review is to describe the choroid plexus tumors (CPTs) occurring in the fetus and neonate with regard to clinical presentation, location, pathology, treatment, and outcome. Materials and methods Case histories and clinical outcomes were reviewed from 93 cases of fetal and neonatal tumors obtained from the literature and our own institutional experience from 1980 to 2016. Results Choroid plexus papilloma (CPP) is the most common tumor followed by choroid plexus carcinoma (CPC) and atypical choroid plexus papilloma (ACPP). Hydrocephalus and macrocephaly are the presenting features for all three tumors. The lateral ventricles are the main site of tumor origin followed by the third and fourth ventricles, respectively. CPTs of the fetus are detected most often near the end of the third trimester of pregnancy by fetal ultrasound. The extent of surgical resection plays an important role in the treatment and outcome. In spite of excellent survival, which is especially true in the case of CPP, surgical resection may carry significant risks in an immature baby. Given the neonatal low blood volume and increased vascularity of the tumors, there is potential risk for hemorrhage. Although advances in neurosurgical techniques have led to a greater degree of complete surgical resections, survival for the perinatal CPC group remains low even with multimodality therapies. Conclusion Perinatal CPTs have variable overall survivals depending on degree of surgical resection and tumor biology. An increased understanding of the molecular features of these tumors may lead to improved therapies and ultimately survival. Keywords Fetal choroid plexus papilloma. Neonatal choroid plexus papilloma. Fetal choroid plexus carcinoma. Neonatal choroid plexus carcinoma. Fetal atypical choroid plexus papilloma. Neonatal atypical choroid plexus papilloma. Congenital brain tumor. Intracranial hemorrhage

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Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives

Cited by 28 publications

References 51 publications

Choroid plexus carcinoma: review of literature

Choroid plexus carcinoma: review of literature

Carcinoma de plexo coroideo en paciente pediátrico: Reporte de caso

Perinatal (fetal and neonatal) choroid plexus tumors: a review

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