Pediatric cervicofacial lymphadenitis caused by Bartonella henselae

Lindeboom, Jerôme A.

doi:10.1016/j.oooo.2015.06.031

Cited by 23 publications

(17 citation statements)

References 24 publications

(43 reference statements)

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“…Las linfadenopatías pueden ser eritematosas, no induradas y el 10-15 % puede supurar. 1,3,5 Aunque el compromiso visceral (microabscesos hepatoesplénicos) es inusual, es relevante su diagnóstico sobre todo en niños, porque se presenta en el 2 % al 25 % de los pacientes descritos en algunas series. Esta infección suele presentarse con síntomas sistémicos como fiebre prolongada y microabscesos en el hígado y/o el bazo, que tienen una típica forma estrellada en estudios complementarios, como ecografía y TAC abdominal.…”

Section: Discussionunclassified

“…Todos estos hallazgos estuvieron presentes en la paciente del caso clínico presentado. 1,3,6 Otras manifestaciones clínicas menos frecuentes no evidenciadas en la paciente presentada son las oculares: el síndrome oculoglandular de Parinaud, que consiste en fiebre, conjuntivitis folicular (inyección conjuntival, secreción serosa, sensación de cuerpo extraño), y también se puede presentar como neurorretinitis, panuveítis, y desprendimiento de retina. 1,7 Las complicaciones neurológicas se han observado en menos del 2 % de los pacientes.…”

Section: Discussionunclassified

“…La infección por Bartonella henselae (BH), un bacilo gramnegativo, transmitida en su mayoría por el arañazo de un gato, puede cursar como una infección asintomática hasta desarrollar infección multiorgánica y, en ocasiones, la muerte. [1][2][3] El compromiso hepatoesplénico en pacientes inmunocompetentes es poco habitual, pero de relevancia en la edad pediátrica. Por lo anterior, sospechar este tipo de infección es fundamental para implementar un tratamiento oportuno y mejorar la calidad de vida de los pacientes.…”

Section: Introductionunclassified

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Compromiso hepatoesplénico, un hallazgo inusual secundario a enfermedad por arañazo de gato: a propósito de un caso

2021

Arch Argent Pediat

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Presentación de casos clínicos RESUMENLa infección por Bartonella henselae (BH) que causa la enfermedad por arañazo de gato puede cursar de manera asintomática, así como presentar manifestaciones locales y sistémicas. El objetivo de este caso es documentar que el compromiso hepatoesplénico es poco habitual en este tipo de infección y el tratamiento, que debe ser personalizado, aún genera controversia. Se presenta un caso de una paciente de 11 años con fiebre de origen de desconocido con hallazgos en tomografía y ecografía abdominal de abscesos hepatoesplénicos, y confirmación de infección por BH a través de métodos serológicos. Se realiza una revisión bibliográfica donde se evidencia la baja frecuencia de compromiso hepatoesplénico. De esta manera, la anamnesis y el examen físico son fundamentales para realizar un rápido diagnóstico y tratamiento. Palabras clave: absceso abdominal, Bartonella henselae, enfermedad por arañazo de gato, fiebre de origen desconocido, pediatría.

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Section: Discussionunclassified

Section: Introductionunclassified

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Compromiso hepatoesplénico, un hallazgo inusual secundario a enfermedad por arañazo de gato: a propósito de un caso

2021

Arch Argent Pediat

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“…In this study, we have employed real-time PCR of the B . henselae RibC gene to confirm CSD diagnosis in patients with lymphadenopathy and/or one of the other diagnostic criteria [12,15,23,27]. Through this approach, we were able to detect B .…”

Section: Discussionmentioning

confidence: 99%

Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study

et al. 2019

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Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae, usually characterized by self-limiting regional lymphadenopathy and fever. Given the low clinical diagnostic sensitivity and specificity of conventional anti-B. henselae indirect immunofluorescence assays (IFAs), real-time polymerase chain reaction (PCR)-based detection of B. henselae is now being proposed as a more sensitive tool to diagnose CSD. Thus, here we have assessed the efficacy of real-time PCR in detecting B. henselae in different specimens from patients with suspected CSD and compared it to that of IFA. From March 2011 to May 2016, at the Microbiology and Virology Unit, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Turin, Italy, 115 clinical specimens (56 aspirated pus, 39 fresh lymph node biopsies, and 20 whole blood samples) and 99 sera from 115 patients with suspected CSD (62 females and 53 males between the ages of 3 months and 68 years) were analyzed by both real-time PCR, used in a qualitative way, and IFA (IgM and IgG) for the presence of B. henselae. For 16 patients, serological results were not available due to a clinical decision not to request the test. B. henselae DNA positivity was detected by real-time PCR in 37.39% of patients, while 62.61% of them were negative. Thus, patients were divided into two groups: real-time PCR+ (n = 43) and real-time PCR- (n = 72). Real-time PCR screening of whole blood, biopsies, and aspirated pus revealed B. henselae positivity in 40%, 38.46%, and 35.71% of patients, respectively. When we analyzed samples by IFA, we found the presence of B. henselae in 28 out of 99 (28.28%) patients, of which 11 (11.11%) belonged to the real-time PCR+ group and 17 (17.17%) to the real-time PCR- group. Among the 71 seronegative subjects, 16 (16.16%) were found positive for B. henselae by real-time PCR. Thus, by combining the results of both assays, we were able to increase the percentage of B. henselae positive specimens from 27.27% (real-time PCR) or 28.28% (IFA) to 44.44% (real-time PCR+IFA). Altogether, these findings indicate that the early detection of B. henselae in patients with suspicious CSD through combined real-time PCR and serological analyses can lead to a more accurate diagnosis of CSD, thereby allowing prompt and appropriate disease management.

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“…Thus, we included 427 patients with chronic cervicofacial lymphadenopathy. Among these, 290 had microbiologically confirmed cervicofacial mycobacterial infections (n=3 M. tuberculosis, n=1 M. bovis, and n=286 NTM), 53 had Bartonella henselae infections 17 , 14 had streptococcal infections, 11 had staphylococcal infections, and 3 had toxoplasmosis. Another 18 children had persistent lymph-node swelling from other causes (n=8 malignancies and n=10 congenital cysts).…”

Section: Patientsmentioning

confidence: 99%

Long-Term Outcome of Surgical Treatments for Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children

Willemse¹,

Schreuder²,

Apperloo³

et al. 2022

Journal of Oral and Maxillofacial Surgery

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Pediatric cervicofacial lymphadenitis caused by Bartonella henselae

Cited by 23 publications

References 24 publications

Compromiso hepatoesplénico, un hallazgo inusual secundario a enfermedad por arañazo de gato: a propósito de un caso

Compromiso hepatoesplénico, un hallazgo inusual secundario a enfermedad por arañazo de gato: a propósito de un caso

Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study

Long-Term Outcome of Surgical Treatments for Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children

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