Pediatric Cancers: Insights and Novel Therapeutic Approaches

Agarwal, Saurabh

doi:10.3390/cancers15143537

Cited by 4 publications

(2 citation statements)

References 26 publications

(28 reference statements)

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“…Pediatric cancers impose a somber burden on the lives of numerous children and their families, standing as a prominent cause of mortality among children globally. Despite notable progress in medical research and treatment approaches, addressing pediatric cancers remains an arduous and pressing imperative [20,21].…”

Section: Introductionmentioning

confidence: 99%

Demographic Analysis of Cancer Research Priorities and Treatment Correlations

Horgan,

Van den Bulcke,

Malapelle

et al. 2024

Current Oncology

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Understanding the diversity in cancer research priorities and the correlations among different treatment modalities is essential to address the evolving landscape of oncology. This study, conducted in collaboration with the European Cancer Patient Coalition (ECPC) and Childhood Cancer International-Europe (CCI-E) as part of the “UNCAN.eu” initiative, analyzed data from a comprehensive survey to explore the complex interplay of demographics, time since cancer diagnosis, and types of treatments received. Demographic analysis revealed intriguing trends, highlighting the importance of tailoring cancer research efforts to specific age groups and genders. Individuals aged 45–69 exhibited highly aligned research priorities, emphasizing the need to address the unique concerns of middle-aged and older populations. In contrast, patients over 70 years demonstrated a divergence in research priorities, underscoring the importance of recognising the distinct needs of older individuals in cancer research. The analysis of correlations among different types of cancer treatments underscored the multidisciplinary approach to cancer care, with surgery, radiotherapy, chemotherapy, precision therapy, and biological therapies playing integral roles. These findings support the need for personalized and combined treatment strategies to achieve optimal outcomes. In conclusion, this study provides valuable insights into the complexity of cancer research priorities and treatment correlations in a European context. It emphasizes the importance of a multifaceted, patient-centred approach to cancer research and treatment, highlighting the need for ongoing support, adaptation, and collaboration to address the ever-changing landscape of oncology.

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Section: Introductionmentioning

confidence: 99%

Demographic Analysis of Cancer Research Priorities and Treatment Correlations

Horgan,

Van den Bulcke,

Malapelle

et al. 2024

Current Oncology

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“…Cancer is the leading cause of death by disease in children and adolescents in the United States, with an incidence rate of approximately 175 per 1 million [1]. Leukemia constitutes 28% of all childhood cancers, while all solid tumors make up approximately 40% of childhood cancers [2]. Among solid tumors, tumors involving the central nervous system (CNS), including the brain and/or spine, are the most common solid tumors in this population [1].…”

Section: Introductionmentioning

confidence: 99%

Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers

Roy,

Subramaniam,

Chong

et al. 2024

Cancers

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Pediatric cancers are the leading cause of disease-related deaths in children and adolescents. Most of these tumors are difficult to treat and have poor overall survival. Concerns have also been raised about drug toxicity and long-term detrimental side effects of therapies. In this review, we discuss the advantages and unique attributes of zebrafish as pediatric cancer models and their importance in targeted drug discovery and toxicity assays. We have also placed a special focus on zebrafish models of pediatric brain cancers—the most common and difficult solid tumor to treat.

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