Pediatric bone evaluation with HR-pQCT: A comparison between standard and height-adjusted positioning protocols in a cohort of teenagers with chronic kidney disease

Vierge, M.; Preka, Evgenia; Ginhoux, Tiphanie; Chapurlat, Roland; Ranchin, Bruno; Bacchetta, Justine

doi:10.1016/j.arcped.2019.02.003

Cited by 2 publications

(1 citation statement)

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“…HR-pQCT. HR-pQCT measurements were performed at the non-dominant limb unless there was a history of fracture, as previously reported by our team in children 24 . Volumetric bone mineral density (vBMD) and bone microstructure were measured at the distal radius and tibia using a HR-pQCT device (XtremeCT, SCANCO Medical AG, Brüttisellen, Switzerland) that acquires a stack of 110 parallel CT slices with an isotropic voxel size of 82 µm.…”

Section: Healthy Volunteersmentioning

confidence: 99%

A prospective case–control pilot study to evaluate bone microarchitecture in children and teenagers on long-term parenteral nutrition using HR-pQCT

Louazon

Poinsot

Restier

et al. 2021

Sci Rep

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Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving long-term PN. This cross-sectional, case–control study included children older than 9 years undergoing PN for at least 2 years. They were age-, gender- and puberty-matched with healthy controls (1:2). Evaluation included biological assessment of bone metabolism (serum calcium, phosphate, and albumin; urinary calcium and creatinine; 25-OH vitamin D, osteocalcin and PTH), dual X-ray absorptiometry (DXA) and HR-pQCT at the ultradistal tibia and radius. Results are presented as median [range]. Eleven patients (3 girls) with a median age of 16 [9–19] years were included. Bone parameters assessed by HR-pQCT at the ultradistal radius and tibia were similar in patients and controls. Parathyroid hormone (PTH) levels were higher (14 [7–115] vs 16 [12–27]) and osteocalcin levels were lower (44 [15–65] vs 65 [38–142]) in patients than in controls, although within the normal range. Conclusions: there were no differences for compartmental bone densities and microarchitecture in patients undergoing chronic PN. Further longitudinal studies are required to confirm these quite reassuring preliminary results.

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Section: Healthy Volunteersmentioning

confidence: 99%