Pediatric biopsy of a single native kidney

Greenbaum, Laurence; Simckes, Ari M.; McKenney, Daniel W.; Kainer, Gad; Nagaraj, Shashi; Trachtman, Howard; Alon, Uri

doi:10.1007/s004670000417

Cited by 13 publications

(4 citation statements)

References 33 publications

(53 reference statements)

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“…This is slightly higher than previously published complication rates for renal biopsies in patients with normal renal function, with the prevalence of minor and major complications occurring 10 and 0.5% respectively [9,10,11]. However, no studies have looked at bleeding rates post-biopsy in patients with renal failure, and the routine use of ultrasound immediately on completion of a biopsy is very sensitive to the presence of any small hematoma at the biopsy site which is recorded in the interventional report.…”

Section: Discussioncontrasting

confidence: 48%

Pre-Procedure Desmopressin Acetate to Reduce Bleeding in Renal Failure: Does It Really Work?

Radhakrishnan¹,

Chanchlani²,

Connolly

et al. 2014

Nephron Clin Pract

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Background: Desmopressin (DDAVP) is often used prior to procedures to minimize bleeding in patients with renal failure; however, there is little evidence to support this practice. The objectives of this study were to evaluate the practice of administration of DDAVP prior to procedures within our division and to determine the number of bleeding episodes for patients who received DDAVP compared to those who did not. Methods: Hospital records of patients who underwent renal biopsy or central line placement between April 2006 and March 2008 were reviewed. Patients with glomerular filtration rate (GFR) <60 ml/min/1.73 m² were identified and subcategorized into three groups: group A GFR <15 ml/min/1.73 m², group B GFR 15-29 ml/min/1.73 m², and group C GFR 30-60 ml/min/1.73 m². The number of bleeding events was noted in each group. Results: No significant difference was found in the number of bleeding events between those who received and did not receive DDAVP overall and in each GFR group. A possible trend towards the benefit with treatment in group A was observed. Conclusion: There was no significant reduction in bleeding for those who received DDAVP which questions the validity of this practice. Patients with GFR <15 ml/min/1.73 m² may possibly derive benefit.

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Section: Discussioncontrasting

confidence: 48%

Pre-Procedure Desmopressin Acetate to Reduce Bleeding in Renal Failure: Does It Really Work?

Radhakrishnan¹,

Chanchlani²,

Connolly

et al. 2014

Nephron Clin Pract

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“…There was 1 child with FSGS due to hyperfiltration injury and 1 child with idiopathic membranous glomerulonephritis. There are several case reports on FSGS in patients with solitary kidneys [37][38][39][40] . These reports suggest that the appearance of proteinuria and focal glomerulosclerosis in patients with a solitary kidney could be due to chronic glomerular hyperfiltration, mainly if intrinsic abnormalities (reflux nephropathy or urinary obstruction) are present in the solitary kidney.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Seeman

Patzer

John

et al. 2006

Kidney Blood Press Res

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Background/Aim: Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. Methods: Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. Results: Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. Conclusions: Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.

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“…Undoubtedly, percutaneous renal biopsy substantially aids clinical nephrology by providing precise diagnoses, prognostic insights, and facilitating tailored treatment for patients with kidney issues (Greenbaum et al, 2000). Nonetheless, the procedure's associated risks of morbidity and occasional mortality necessitate tailored risk-benefit https://digital-science.pubmedia.id/index.php/phms evaluations for each patient, a process prone to subjectivity (Iversen & Brun, 1951;Kuller et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

The Value of Biopsy in Histopathological Diagnosis

Akhrorkulovich,

Makhsudovich,

Oltinbaevich

2024

phms

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In this prospective study, 78 renal biopsies were performed: 46 men and 32 women. The average age of men was 37 ± 18.3 years, and that of women was 24.6 ± 13.8 years. Most often, biopsy was performed in the age group from 19 to 48 years among both men (58.6%) and women (66.7), respectively. The most common age group undergoing biopsy was between 19 and 48 years of age for both men (76.1%) and women (78.1%). There were 18 patients over 45 years of age (23.1%): 11 men and 7 women. The primary reason for renal biopsy was the presence of proteinuria with hematuria and subnephrotic proteinuria in 26 patients, followed by nephrotic syndrome in 12 patients. IgA nephropathy emerged as the most frequently identified histopathological diagnosis, accounting for 17.7% of cases. Conversely, minimal change disease, the second most prevalent histopathological finding at 10.4%, was identified in patients with nephrotic syndrome; their renal biopsies appeared normal under histological examination due to the absence of electron microscopy analysis. Nephrosclerosis ranked as the third most common histopathological diagnosis among patients at 6.7%. Additional findings included focal segmental glomerulosclerosis (7.3%), membranous glomerulonephritis (7%), mesangiocapillary glomerulonephritis (7%), and chronic graft rejection (2.6%) in two patients with accompanying fasting and transplant azotemia. Acute tubular necrosis and chronic interstitial nephritis were each present in 1.3% of patients, while 9.0% of cases yielded inconclusive results, indicating either a blood clot or brain tissue in the biopsy samples.

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Pediatric biopsy of a single native kidney

Cited by 13 publications

References 33 publications

Pre-Procedure Desmopressin Acetate to Reduce Bleeding in Renal Failure: Does It Really Work?

Pre-Procedure Desmopressin Acetate to Reduce Bleeding in Renal Failure: Does It Really Work?

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

The Value of Biopsy in Histopathological Diagnosis

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