Pediatric Atorvastatin in Diabetes Trial (PADIT): A Pilot Study to Determine the Effect of Atorvastatin on Arterial Stiffness and Endothelial Function in Children with Type 1 Diabetes Mellitus

Haller, Michael J.; Stein, Jennifer; Shuster, Jonathan J.; Theriaque, Douglas W.; Samyn, Margaret M.; Pepine, Carl J.; Silverstein, Janet H.

doi:10.1515/jpem.2009.22.1.65

Cited by 35 publications

(33 citation statements)

References 6 publications

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“…Certain drugs have been successfully used for the management of ED and AS and therefore for the prevention of potential DM complications. [12][13][14] Early diagnosis and early management of ED and AS may reduce diabetic complications. In this study, we aimed to detect ED and AS and determine the association with diastolic dysfunction in children with DM who had no complications.…”

Section: Discussionmentioning

confidence: 99%

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

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Objective: The objective of this study is to investigate endothelial dysfunction (ED) and arterial stiffness (AS) and determine the association with diastolic dysfunction in children with type 1 diabetes mellitus (DM). Methods: A total of 42 patients without diabetic complications (mean age: 13.21 years) and 40 healthy (mean age: 13.07 years) children were included in this study. AS was assessed with ascending aorta M-mode measurements, diastolic dysfunction with pulsed wave (PW) Doppler and tissue Doppler echocardiography measurements and flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT) with high-resolution ultrasonography. Results: Results of diabetic group and healthy children were compared. In diabetic group, aortic strain (8.40 ± 2.98, 20.12 ± 5.04; p < 0.001), aortic distensibility (7.36 ± 2.92, 16.59 ± 4.25; p < 0.001) and FMD% (7.70 ± 2.83, 11.33 ± 2.85; p < 0.001) were found decreased, and CIMT (0.52 ± 0.09 mm, 0.47 ± 0.08 mm; p < 0.05) was found increased. Additionally, left ventricular lateral segment and right ventricular free-wall isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were found increased. Correlation analyses demonstrated a negative correlation between FMD and IVRT and MPI. Conclusions: ED and AS were found in type 1 DM patients without diabetic complications. Additionally, correlation was shown between increased AS and ED and right and left ventricular diastolic dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

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“…Few studies have specifically examined the effect of intensive pharmacological therapy on CVD risk factor reduction in children with T1DM, although 1 study suggested a trend toward improved endothelial function after 12 weeks of atorvastatin 20 mg/d. 231 The American Academy of Pediatrics, the American Heart Association, and the ADA recognize patients with DM, and particularly T1DM, as being in a higher-risk group who should receive more aggressive risk factor screening and treatment than nondiabetic children. 125,228,229,232 The National Heart, Lung, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents has specific lifestyle and pharmacotherapy recommendations for children with lipid abnormalities and specifies management for children with T1DM.…”

Section: Cvd Risk Factors In Children With T1dmmentioning

confidence: 99%

Type 1 Diabetes Mellitus and Cardiovascular Disease

Ferranti¹,

Boer²,

Fonseca³

et al. 2014

Circulation

300

126

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“…5,6,61,62,64 However, it is important to note that FMD has been previously shown to be significantly associated with arterial stiffness under a number of conditions and disease states. [122][123][124][125][126] Wright et al 127 noted that this association was weak and suggested that measurements of arterial stiffness should not replace FMD. However, they used neither AIx nor cfPWV (the 'gold standard') as arterial stiffness measurements in their study.…”

Section: Mechanismsmentioning

confidence: 99%

The effect of smoking on arterial stiffness

et al. 2010

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A systematic literature review was conducted using PubMed, Embase and the Cochrane Library to determine the effect of acute, chronic and passive smoking on arterial stiffness and to determine whether these effects are reversible after smoking cessation. A total of 39 relevant studies were identified and included. Acute smoking was found to cause an acute increase in arterial stiffness. Similarly, passive smoking increased arterial stiffness acutely and chronically. The majority of studies identified chronic smoking as a risk factor for increasing arterial stiffness. However, some studies found no statistical difference in arterial stiffness between nonsmokers and long-term smokers, although chronic smoking seems to sensitize the arterial response to acute smoking. In addition, whether arterial stiffness is reversed after smoking cessation and the timeline in which this may occur could not be determined from the identified literature. The effect of smoking discontinuation on arterial stiffness remains to be established by prospective smoking cessation trials.

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Pediatric Atorvastatin in Diabetes Trial (PADIT): A Pilot Study to Determine the Effect of Atorvastatin on Arterial Stiffness and Endothelial Function in Children with Type 1 Diabetes Mellitus

Cited by 35 publications

References 6 publications

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Type 1 Diabetes Mellitus and Cardiovascular Disease

The effect of smoking on arterial stiffness

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