Pediatric arsenic ingestion

Cullen, Natalie M; Wolf, Leslie R.; Clair, Douglas St

doi:10.1016/0735-6757(95)90133-7

Cited by 50 publications

(23 citation statements)

References 17 publications

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“…Encephalopathy, peripheral neuropathy, lethargy, paresthesia, weakness, confusion, hallucination and coma Humans Armstrong et al (1984); Cullen et al (1995); Fincher and Koerker (1987); Foy et al (1992); Franzblau and Lilis (1989); Hantson et al (1996); Kamijo et al (1998);Quatrehomme et al (1992); Silver and Wainman (1952) …”

Section: Neurological Effectsmentioning

confidence: 99%

“…Oral exposure (inorganic arsenic) Gastrointestinal effects Vomiting, diarrhea, abdominal pain, inflammation, bleeding or ulceration of the gastrointestinal tract Humans Armstrong et al (1984); Civantos et al (1995); Cullen et al (1995); Fincher and Koerker (1987); Franzblau and Lilis (1989); Goebel et al (1990); Kamijo et al (1998) Anemia, pancytopenia and leukopenia Humans Armstrong et al (1984); Fincher and Koerker (1987); Franzblau and Lilis (1989); Hopenhayn et al (2006); Mizuta et al (1956) …”

Section: Effect Description Species Referencesmentioning

confidence: 99%

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A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

103

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Section: Neurological Effectsmentioning

confidence: 99%

Section: Effect Description Species Referencesmentioning

confidence: 99%

A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

103

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“…This finding correlates with a report of pediatric spontaneous excretion twice as fast as in adults. 42 These distinctions may make extracorporeal elimination techniques more effective in the pediatric population.…”

Section: Figmentioning

confidence: 99%

Acute Arsenic Poisoning in Two Siblings

et al. 2005

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We report a case series of acute arsenic poisoning of 2 siblings, a 4-month-old male infant and his 2-year-old sister. Each child ingested solubilized inorganic arsenic from an outdated pesticide that was misidentified as spring water. The 4-month-old child ingested a dose of arsenic that was lethal despite extraordinary attempts at arsenic removal, including chelation therapy, extracorporeal membrane oxygenation, exchange transfusion, and hemodialysis. The 2-year-old fared well with conventional therapy.

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“…It has also been successfully used for elemental, inorganic and organic mercury, arsenic, antimony, and copper chelation in humans [136,138,[149][150][151][152]. In animal experiments, meso-DMSA was an efficient chelator for gold [153][154][155][156] and nickel [104,105].…”

Section: Meso-23-dimercaptosuccinic Acid (Succimer Meso-dmsa)mentioning

confidence: 99%

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

Blanuša¹,

Varnai²,

Piasek³

et al. 2005

CMC

236

150

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The effects of chelating drugs used clinically as antidotes to metal toxicity are reviewed. Human exposure to a number of metals such as lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel and platinum may lead to toxic effects, which are different for each metal. Similarly the pharmacokinetic data, clinical use and adverse effects of most of the chelating drugs used in human metal poisoning are also different for each chelating drug. The chelating drugs with worldwide application are dimercaprol (BAL), succimer (meso-DMSA), unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa(2)EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa(3)DTPA, ZnNa(3)DTPA), deferoxamine (DFO), deferiprone (L1), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects. These include three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), the derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA) and the carbodithioates. Many factors have been shown to affect the efficacy of the chelation treatment in metal poisoning. Within this context it has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age. These findings may have a bearing in the design of new therapeutic chelation protocols for metal toxicity.

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Pediatric arsenic ingestion

Cited by 50 publications

References 17 publications

A review on exposure and effects of arsenic in passerine birds

A review on exposure and effects of arsenic in passerine birds

Acute Arsenic Poisoning in Two Siblings

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

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