Pediatric Appendicitis

Rentea, Rebecca M.; Peter, Shawn D. St.

doi:10.1016/j.suc.2016.08.009

Cited by 63 publications

(62 citation statements)

References 134 publications

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“…21 Sensitivity of increased hs-CRP in diagnosis of the cases with perforated appendicitis was found to be high by Rentea and St Peter. 22 In the present study, it was found that WBC count, NLR, and CRP level were significantly higher in AA group compared with the abdominal pain group and CRP level was higher in the perforated group compared with the nonperforated group. These studies have indicated that the high CRP level is significant in the diagnosis of perforated appendicitis.…”

Section: Discussionsupporting

confidence: 52%

“…It was reported that the perforation rate changes with age, between 20 and 76%, and this rate is higher for younger patients. [22][23][24] In the present study, it was found that the perforation rate was 25% and the mean age of the perforated group was 8.3 AE 3.8 years. In addition, the mean age of the perforated group was significantly lower than the nonperforated group.…”

Section: Discussionsupporting

confidence: 50%

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The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

Uğur

Madenci

Kurku

et al. 2020

Journal of Pediatric Infectious Diseases

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Objective The aim of this study was to determine the role of thiol/disulfide homeostasis (TDH) parameters which are new oxidative stress markers for the diagnosis of acute appendicitis (AA) in children with abdominal pain complaints. Methods A total of 40 patients with AA and 45 patients with abdominal pain were included in this study. Two groups were compared in terms of age, gender, white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), appendix diameter, and TDH parameters (native and total thiol levels, native thiol/total thiol ratio [antioxidant parameters] and disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio [oxidant parameters]). Results Compared with the abdominal pain group, it was found that disulfide level, disulfide/native thiol, and disulfide/total thiol ratios (p < 0.001 for all) in patients with AA were significantly higher and their native thiol level (p = 0.02) and native thiol/total thiol ratio (p < 0.001) were significantly lower. There was no significant difference between the two groups in terms of total thiol level. There was no significant difference between the perforated and nonperforated groups in patients with AA in terms of TDH parameters. In addition, the CRP level was higher in the perforated group than the nonperforated group. Conclusion To our knowledge, the present study is a first in the literature in which TDH parameters were used in children with AA compared with the abdominal pain group. We thought that these parameters may be useful as new biomarkers supporting AA diagnosis in children.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionsupporting

confidence: 50%

The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

Uğur

Madenci

Kurku

et al. 2020

Journal of Pediatric Infectious Diseases

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“…1 Although classic symptoms are well known, they are uncommon and often misinterpreted in pediatric patients, potentially delaying diagnosis and resulting in rare complications. 2,3 Pericardial effusion and/ or pericarditis secondary to perforated appendicitis has been described in pediatric patients. 4 We report the first case of cardiac tamponade, a life-threatening condition resulting in hemodynamic compromise, due to appendicitis.…”

Section: To the Editormentioning

confidence: 99%

Cardiac tamponade as a rare complication of pediatric perforated appendicitis

Saha

Aoyama

Levine

2019

Can J Anesth/J Can Anesth

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“…3,[6][7][8][9] Moreover, variability in practice exists regarding the necessity and timing of performing appendectomy altogether for patients with appendicitis. [10][11][12][13] Many institutions in the United States have created clinical pathways for managing children with perforated appendicitis. These pathways are often inconsistently followed, and variability in management is widespread.…”

Section: Introductionmentioning

confidence: 99%

Non-Operative Management is More Cost-Effective than Immediate Operation in Perforated Appendicitis Patients with Seven or More Days of Symptoms

Isani

Jackson

Barry

et al. 2019

Journal of Surgical Research

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Background: Management of perforated appendicitis in children remains controversial. Nonoperative (NO) and immediate operative (IO) strategies are used with varying outcomes. We hypothesized that IO intervention for patients with perforated appendicitis would be more cost-effective than NO management. Methods: A retrospective chart review of all patients with appendicitis from 2012 to 2015 was performed. Patients with perforated appendicitis were defined by evidence of perforation on imaging. We excluded patients who presented with sepsis, organ failure, and ventriculoperitoneal shunts. NO management was determined by surgeon preference. Univariate and multivariate analyses were performed. Results: IO was performed on 145 patients with perforated appendicitis, whereas 83 were treated with NO management. Compared to IO patients, NO patients incurred higher overall costs, greater length of stay, more readmissions, complications, peripherally inserted central venous catheter lines, interventional radiology drains, and unplanned clinic and emergency department visits (P < 0.0001 for all). Multivariate analysis adjusting for age, days of symptoms, admission C-reactive protein and white blood cell count revealed that NO management was independently associated with increased costs (OR 1.35, 1.12-1.62, 95% CI). Cost curves demonstrated that total cost for IO surpasses that of NO management when patients present with greater than 6.3 d of symptoms (P ¼ 0.01). Conclusions: Our data suggest that IO is more cost-effective than NO management for patients with perforated appendicitis who present with less than 6.3 d of symptoms, after which point, NO management is more cost-effective.

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Pediatric Appendicitis

Cited by 63 publications

References 134 publications

The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children

Cardiac tamponade as a rare complication of pediatric perforated appendicitis

Non-Operative Management is More Cost-Effective than Immediate Operation in Perforated Appendicitis Patients with Seven or More Days of Symptoms

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