Pediatric acquired factor VIII deficiency presenting as hemarthrosis

Abstract

Bleeding events are indicated with an asterisk. Intravenous immune globulin (IVIG) doses are indicated with an arrowhead. (a) Prednisone started at 1 mg/kg/dose twice daily; (b) prednisone taper initiated; (c) prednisone discontinued. (B) FVIII inhibitor levels and FVIII activity versus time since diagnosis in case #2. Bleeding events are indicated with an asterisk. (a) Prednisone started at 1 mg/kg/dose twice daily; (b) prednisone taper initiated with 5 mg/dose decrease each week; (c) prednisone discontinued vaccination. As demonstrated with these two cases, immunosuppression with steroids ± IVIG may be curative in pediatric AHA.