Pediatric acquired demyelinating syndrome (ADS) in inpatient hospital settings: The hospitalization rate, costs, and outcomes in the US

Minegishi, Machiko; Takahashi, Tsuyoshi; Testa, Marcia A.

doi:10.1016/j.msard.2019.06.031

Cited by 3 publications

(5 citation statements)

References 39 publications

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“…Inexplicably, some studies take into account very different age limits, and others have insufficient observational periods. 1,2,8,11,12,[20][21][22][23] For all these reasons, the incidence estimates of paediatric multiple sclerosis from ADS among children vary considerably in the literature from 15% to 46%. 12 In our study, the overall risk of paediatric multiple sclerosis after a first demyelinating event was 72% after a mean follow-up of 8 years 5 months, which is higher than in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, paediatric ADS occurs with an incidence between 0.37 and 1.66 new cases per 100 000 children per year, 12 with a consistent female preponderance across studies. However, recent evidence has shown trends for an increasing frequency of paediatric ADS in the Netherlands, 8 Denmark, 2 USA, 22 and Germany 12 …”

Section: Discussionmentioning

confidence: 99%

“…However, the future trajectories of paediatric patients with ADS are still uncertain, and factors such as specific ADS presentations and the proportion of paediatric multiple sclerosis among the paediatric ADS group may predict diagnosis of paediatric multiple sclerosis. Inexplicably, some studies take into account very different age limits, and others have insufficient observational periods 1,2,8,11,12,20–23 . For all these reasons, the incidence estimates of paediatric multiple sclerosis from ADS among children vary considerably in the literature from 15% to 46% 12 …”

Section: Discussionmentioning

confidence: 99%

“…20,21 As a result, paediatric ADS occurs with an incidence between 0.37 and 1.66 new cases per 100 000 children per year, 12 with a consistent female preponderance across studies. However, recent evidence has shown trends for an increasing frequency of paediatric ADS in the Netherlands, 8 Denmark, 2 USA, 22 and Germany. 12 As for Sardinia, the annual incidence of 3.1 per 100 000 and the prevalence of 59.2 per 100 000 point to higher supra (17) infra ( 7) spinal (3) supra + infra (14) supra, infra, + spinal ( 3) rates than previously reported, including those of 2.3 in Denmark, 2 the highest so far reported in a European country.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term trajectory of acquired demyelinating syndrome and multiple sclerosis in children

Eusebi

Zara

Zarbo

et al. 2021

Develop Med Child Neuro

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Aim We assessed the frequency, characteristics, and future trajectory of monophasic acquired demyelinating syndromes (ADS) associated with conversion to paediatric multiple sclerosis. Method This was a retrospective observational study of Sardinian children (<18y of age) with onset of ADS between 2001 and 2018. Results We identified 44 children with ADS (21 males, 23 females; median age at onset 16y, range 4mo–18y), 21 of whom were already presenting with criteria for paediatric multiple sclerosis. The mean crude prevalence of ADS in Sardinian children was 59.2 per 100 000, while incidence was 3.1 per 100 000 per year (1.3 in children aged ≤10y and 11.9 in those aged 10–17y). After a mean (SD) follow‐up of 8 years 5 months (5y 4mo), the most common (n=32) trajectory was conversion to paediatric multiple sclerosis. At onset, the total prevalence and mean annual incidence of paediatric multiple sclerosis were 35.6 per 100 000 and 2.3 per 100 000 respectively (0.5 in individuals aged ≤10y, 10.0 in the older group). Interpretation Sardinia is a very high risk area for ADS in children. Nearly half of this population can already be diagnosed with paediatric multiple sclerosis at onset. Overall, 72% of those with ADS will have paediatric multiple sclerosis after a mean of 8 years. Sardinia is a very high risk area for paediatric acquired demyelinating syndromes (ADS). A high proportion of those with paediatric multiple sclerosis are diagnosed at onset of ADS. After an average 8 years from onset of paediatric ADS, three‐quarters of patients are diagnosed with paediatric multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Long‐term trajectory of acquired demyelinating syndrome and multiple sclerosis in children

Eusebi

Zara

Zarbo

et al. 2021

Develop Med Child Neuro

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“…That's why the medical costs from the Korean patients are lesser than those in US and Canada. Minegishi et al demonstrated the increasing trend of hospital utilization and costs by pediatric ADS in the US from 2003 to 2012 [23]. It emphasized the growing economic and medical burden in ADS in pediatric healthcare, necessitating enhanced resources.…”

Section: Healthcare Utilization and Economic Burden Of Pediatric Adsmentioning

confidence: 99%

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Woo,

Hwang,

Choi

et al. 2024

Children

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Pediatric multiple sclerosis (MS) and neuromyelitis optica (NMO) are rare acquired demyelinating syndrome with limited epidemiological data available, particularly in non-Western setting. This study aimed to demonstrate the epidemiology of pediatric MS and NMO in South Korea and to analyze of healthcare utilization and economic burden associated with these conditions. Using a nationwide population-based database from the Korean Health Insurance Review and Assessment Service database, we identified pediatric cases (age < 20 years) of MS and NMO from 2016 to 2020. We analyzed incidence, prevalence, healthcare utilization and medical costs. The study found low age-standardized incidence and prevalence rates for pediatric MS and NMO in South Korea. There was a marked disparity in healthcare utilization between urban and rural areas. Most healthcare interactions occurred in tertiary hospitals in urban settings, particularly in Seoul. The study also highlighted the substantial economic burden associated with the management of rare diseases, with annual variability in medical costs. Pediatric MS and NMO are extremely rare in South Korea, with significant regional disparity in healthcare utilization. The findings emphasize the need for targeted healthcare policies to improve access and reduce disparities, particularly for chronic and rare diseases requiring specialized care.

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Factors associated with health care utilization in pediatric multiple sclerosis

Marrie

O’Mahony

Maxwell

et al. 2020

Multiple Sclerosis and Related Disorders

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Pediatric acquired demyelinating syndrome (ADS) in inpatient hospital settings: The hospitalization rate, costs, and outcomes in the US

Cited by 3 publications

References 39 publications

Long‐term trajectory of acquired demyelinating syndrome and multiple sclerosis in children

Long‐term trajectory of acquired demyelinating syndrome and multiple sclerosis in children

Epidemiology and Healthcare Utilization in Pediatric Multiple Sclerosis and Neuromyelitis Optica: A Nationwide Population-Based Study in South Korea (2016–2020)

Factors associated with health care utilization in pediatric multiple sclerosis

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