Pedal Neuroarthropathy in a Nondiabetic Patient as a Result of Long-term Amiodarone Use

Charcot Arthropathy of the Foot and Ankle in Patients With Idiopathic Neuropathy

“…Substance abuse, medication side effects, rare infectious disease, and spinal anomalies have been reported to be associated with the development of Charcot arthropathy. 6,9,12,14 In addition, recent work has demonstrated an association with rheumatoid arthritis and Charcot arthropathy. 7 Peripheral neuropathies are common and account for as many as 20% of new patient visits in some neurology clinics.…”

Charcot Arthropathy of the Foot and Ankle Associated With Rheumatoid Arthritis

“…4,24,25,27,28 However, nondiabetic populations with peripheral neuropathy can also develop Charcot arthropathy. 10,14,19,21,30,33 Although not widely recognized, rheumatoid arthritis has been associated with peripheral neuropathy, 1,2,6,7,31 but to the best of our knowledge, no publications have reported Charcot arthropathy in association with rheumatoid arthritis. To investigate the natural history, classification, treatments and outcomes, this study evaluated a series of Charcot arthropathy patients with rheumatoid arthritis.…”

Amiodarone-Induced Neuropathies and Related Neurotoxicities

“…10,16, 18 High concentrations of drug and subsequent enzyme interference lead to the formation of lysosomal phospholipidcontaining inclusions in vulnerable nervous tissue, without the protection of blood nerve barrier, and cause a disruption in normal cell function and integrity. 16,18 The loss of the blood nerve barrier's protective effects in this theory is not well understood, but it is believed that nerve vascular permeability is disrupted, either by the amiodarone itself or the processes of advancing age. 18 Orr and Ahlskog 7 developed a 2-part investigative method to study the frequency and characteristics of v There is no strict temporal relationship between initiation of amiodarone therapy and onset of neurologic disturbances.…”