Peculiarities of the Perturbation of Water Structure by Ions with Various Hydration in Concentrated Solutions of CaCl2, CsCl, KBr, and KI

Penkov, Nikita V.

doi:10.3103/s1541308x19020079

Cited by 26 publications

(14 citation statements)

References 18 publications

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“…The previously shown effect of solutions with low concentrations on the properties of the starting substance or a substance interacting with the starting one (see the Introduction, Refs. [8][9][10][11][12][13]) was confirmed in this study.…”

Section: Discussionsupporting

confidence: 85%

“…We suggest that distant action may play a certain role in the development of the modifying effect of high dilutions on the original substance. Such effect is described in [8][9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 94%

“…Furthermore, the present study analyzed the properties of the protein (IFNγ) dissolved in the above-mentioned solutions at low concentration. Such experiment served as an extension to the studies of the impact of low-concentration solutions of substances on highconcentration solutions of the same substances [8][9][10][11][12][13]. These studies demonstrated that solutions of the substances at ultralow concentration could specifically modify the physical and/or functional properties of the solution of the same substance (or solution of the interacting substance) at high concentration when mixed.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations

Penkov

Pen’kova

2020

Front. Phys.

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In this work, based on the method of infrared emission spectroscopy, the study of emission spectra of interferon-gamma (IFNγ) solution in a mixture or surrounded by three low-concentration solutions (IFNγ, antibodies to IFNγ, glycine buffer) or water control was performed. First of all, the solutions of low concentrations themselves were studied. It was shown that low-concentration solutions of IFNγ and antibodies to IFNγ had lower emission intensity in three spectral bands near 800, 1,300 and 2000 cm−1 compared to water control. Glycine buffer solution had a radiation level indistinguishable from that of the control. In this work, the effect of adding these low-concentration solutions to IFNγ (1 mg/ml) was compared to the effect of adding water control to IFNγ. All solutions or water were added in 10% (v/v). It was found that adding each of the three test solutions induced an increase in the radiation intensity of the IFNγ solution in the spectral range of 400–1700 cm−1 (compared to the IFNγ solution with control spike). It was also tested whether the radiation of the studied low-concentration solutions surrounding the IFNγ solution (1 mg/ml) affected the IFNγ radiation. The measurement results were compared to the data obtained for IFNγ surrounded by water control. All three solutions were found to exert a distant effect on the IFNγ solution (1 mg/ml), which was manifested in a decrease in the intensity of its radiation near 1,000 and 1,500 cm−1 compared to the control solution of IFNγ. Thus, the emission spectra of low-concentration aqueous solutions were measured for the first time, and differences in the emission spectra of the IFNγ solution depending on low-concentration additives and the environment were shown. The paper interprets the observed differences and discusses possible mechanisms underlying the observed phenomena.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations

Penkov

Pen’kova

2020

Front. Phys.

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“…In particular, it has been shown that high dilutions of antibodies can be used to treat various diseases [24][25][26][27][28]. High dilutions exert a modifying effect on the properties of the starting material [29][30][31][32][33], despite the colossal difference in the quantities of mixed substances (of the original substance and its high dilution). All this indicates that in the process of dilution the organization of hydration shells of molecules can change which determines the effects of high dilutions [34].…”

Section: Introductionmentioning

confidence: 99%

Development of Terahertz Time-Domain Spectroscopy for Properties Analysis of Highly Diluted Antibodies

Penkov

Фесенко

2020

Applied Sciences

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This work represents the development of a three-band (Debye relaxation, intermolecular bending, and stretching vibrational bands) approach to the terahertz time-domain spectroscopy (THz-TDS) for the analysis of aqueous solutions of lactose saturated with highly diluted (HD) antibodies to interferon-gamma. Since THz-TDS is sensitive to a very slight changes in water properties, we aimed to assess its applicability for the analysis of HD antibodies. To evaluate water features in tested samples we also used Fourier transform infrared spectroscopy, considering the first overtone of intramolecular stretching vibrations of water molecules. We showed a broadening of the energy distribution of intermolecular bonds in the solution of HD substances in comparison to the control solution. This broadening corresponded to the presence of an active component even in HD samples. The results of both methods were similar; however, with the THz-TDS it was possible to analyze the changes in energy distribution of intermolecular (hydrogen) bonds in the solutions. Therefore, our approach to THz-TDS method is applicable for analyzing structural properties of the solutions containing HD antibodies and for the indirect investigation of altered aqueous properties in water solutions when direct measurements of a substance concentration are not available.

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“…The serial ultra high dilution (UHD) process seems to have potential to cause an effect on the parameters of high-density ceramics, improving the production techniques, and expanding the applications of devices based on such materials. It has been previously shown that process of multiple sequential dilution of starting materials leads to a significant change in the properties of the resulting solutions (structuredness, kinetic and thermodynamic characteristics) in comparison with solutions that have not been subjected to such treatment 28,29 . When added to the original substance UHD solutions may affect its properties as well 30 .…”

mentioning

confidence: 99%

Piezoelectric and dielectric properties of Bi3TiNbO9 prepared by hot pressing from powders activated using the serial dilution method

Спицин

Bush

Kamentsev

2020

Sci Rep

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Bi-based layer structure ferroelectrics are the most promising compounds for the fabrication of high-temperature piezoelectric materials. Studies aiming to develop and optimize the techniques to produce efficient high-density piezoelectric ceramics, and to investigate the effects of ceramics production conditions on their structure and functional properties, have become high-priority objectives of modern piezo-engineering. We applied ultra high dilution (UHD) technology to pre-treat Bi3TiNbO9 powders and used hot pressing to prepare perovskite-layer structured ceramic specimens. Main characteristics of the synthesized piezoelectric ceramic specimens (the dimensions of the Bi3TiNbO9 orthorhombic unit cell, dielectric permittivity, dielectric loss, piezoelectric coefficient d33 and pyroelectric coefficient pσ) and their temperature-dependent variations were studied using piezoelectric, dielectric, and pyroelectric measurements. X-ray diffraction studies demonstrated that the prepared ceramics were single phased, and highly textured, as their plate-like crystallites were preferentially aligned perpendicularly to the pressure axis on hot pressing. For d33, an increase in values of more than 20% was found for samples obtained using a combined modification of the UHD technology and hot pressing (12 pC/N) relative to intact samples, and more than two times relative to unmodified Bi3TiNbO9 ceramics (6 pC/N). Due to their characteristics, the obtained ceramics are promising materials for high-temperature applications; of particular interest is potential use, as electroacoustic transducers and sensors for operation at high temperatures. Thus, the UHD technology can modify the properties of ceramics and is relatively easy to implement. This makes it attractive for use in various fields of science and technology.

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Peculiarities of the Perturbation of Water Structure by Ions with Various Hydration in Concentrated Solutions of CaCl2, CsCl, KBr, and KI

Cited by 26 publications

References 18 publications

Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations

Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations

Development of Terahertz Time-Domain Spectroscopy for Properties Analysis of Highly Diluted Antibodies

Piezoelectric and dielectric properties of Bi3TiNbO9 prepared by hot pressing from powders activated using the serial dilution method

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