Peculiarities of the effect of low-dose-rate radiation simulating high-altitude flight conditions on mice in vivo

Заичкина, С. И.; Rozanova, O. M.; Aptikaeva, G. F.; Akhmadieva, A.Kh.; Смирнова, Е. Н.; Романченко, С. П.; Сирота, Н. П.; Vachrusheva, O. A.; Peleshko, V. N.

doi:10.1007/s00411-007-0107-2

Cited by 12 publications

(3 citation statements)

References 16 publications

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“…In this way, activation of the high fidelity C-NHEJ (or ADR) pathway, although not excluding joining of illegitimate ends, by low doses of low-LET radiation suppresses the microhomology-mediated error-prone Alt-NHEJ or HR pathways, and hence mitigates the genomic insult caused by DSBs arising from radiation exposure or fork arrest by genotoxins. Such a choice is not the case for high doses (>0.1 Gy) or high-LET radiation, which not only are unable to elicit ADR but also invalidate the ADR response to low-LET radiation [148, 149]. The low dose abnormality in Nagasaki could be a case in question.…”

Section: Perspectivesmentioning

confidence: 99%

Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

Sasaki

Tachibana

Takeda

2013

Journal of Radiation Research

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Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and Nagasaki arising from limitations in the statistical power and information available on overall radiation dose. To deal with these difficulties, a novel nonparametric statistics based on the ‘integrate-and-fire’ algorithm of artificial neural networks was developed and tested in cancer databases established by the Radiation Effects Research Foundation. The analysis revealed unique features at low doses that could not be accounted for by nominal exposure dose, including (i) the presence of a threshold that varied with organ, gender and age at exposure, and (ii) a small but significant bumping increase in cancer risk at low doses in Nagasaki that probably reflects internal exposure to 239Pu. The threshold was distinct from the canonical definition of zero effect in that it was manifested as negative excess relative risk, or suppression of background cancer rates. Such a unique tissue response at low doses of radiation exposure has been implicated in the context of the molecular basis of radiation–environment interplay in favor of recently emerging experimental evidence on DNA double-strand break repair pathway choice and its epigenetic memory by histone marking.

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Section: Perspectivesmentioning

confidence: 99%

Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

Sasaki

Tachibana

Takeda

2013

Journal of Radiation Research

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“…The research of the biological effect of accelerated heavy particles in animals is insufficient because of the limited sources of high-energy radiation and the complexity of these experiments [9]. A study of low doses of accelerated carbon ions, which are comparable with predicted doses during space flights, will assess the contribution of the genetic risk to the overall spectrum of adverse effects of flight factors.…”

Section: Introductionmentioning

confidence: 99%

THE STUDY OF BIOLOGICAL EFFECTS INDUCED BY ACCELERATED 12C IONS WITH AN ENERGY OF 450 MeV/N ON MICE IN VIVO

Сорокина¹,

Заичкина²,

Rozanova³

et al. 2017

RAD Conference Proceedings

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Abstract. In connection with the active space exploration and the search for new sources for tumor radiotherapy, studies of the effects of low doses of radiation, which are characterized by a high LET, are currently of particular interest. The therapy with heavy charged particles becomes of more and more interest all over the world, and many medical centers tend to use heavy ion beams in radiotherapy. We investigated the biological effects induced by accelerated 12 C ions with an energy of 450 MeV/n in the Bragg peak in a dose range of 0.1-1.5 Gy in mice in vivo. It was found that: (1) the dose dependence of the level of cytogenetic damage in the bone marrow is nonlinear; (2) changes of the thymus and spleen weight index depend on the dose and the quality of radiation, and this index is considerably reduced as compared to that of unirradiated mice; and (3) the level of spontaneous ROS production in blood cells increases in comparison with irradiation at the same doses of X-rays. We calculated the ratio of biological effects under the action of accelerated carbon ions to the effects of same doses of X-ray radiation. The obtained coefficient served as an index of the radiation efficiency (IRE). Thus, it was found that the average IRE value for accelerated carbon ions with an energy of 450 MeV/n in the Bragg peak in the dose range examined varied from 1.1 to 2.4 and was independent of selected biological endpoints in mice in vivo.

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“…Moreover, there is an association between the induction of cell death, chromosomal aberrations, and the frequency of micronucleus formation (Ayed-Boussema et al 2007). Micronuclei are usually formed from acentric segments or from whole chromosomes (with kinetochore abnormalities) (Zaichkina et al 2007). The cytogenetic damage caused by clastogenic agents on the mitotic cell is expressed as an increase in the frequency of micronuclei during the postmitotic interphase after treatment.…”

Section: Discussionmentioning

confidence: 99%

Alleviation of nicotine-induced reproductive disorder, clastogenicity, and histopathological alterations by fenugreek saponin bulk and nanoparticles in male rats

Hamed

El-Fiky

Gawish

et al. 2022

Environ Sci Pollut Res

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Nicotine is the most abundant ingredient in cigarette smoking and has serious side effects on the lung, heart, reproductive system, and many other human organs. Saponins extracted from many plants exhibit multiple biological actions such as anti-cancer effects. Therefore, the possible protective effect of fenugreek saponin (FS) and nanofenugreek saponin (NFS) against nicotine-induced toxicity in male rats was investigated in this study. Animals were divided into a control group and the nicotine (1.5 mg/kg/day), FS (25, 50, and 100 mg/kg/day), or/and NFS (20, 40, and 80 mg/kg/day) administered groups. Micronucleus assay, histopathological, and sperm abnormality examinations as well as measurement of the acetylcholinesterase (AChE) gene expression were conducted. Our findings revealed that nicotine treatment induced significant increases in the incidence of micronucleus, sperm abnormalities, and expression levels of AChE in addition to inducing histopathological changes in rat testis. On the other hand, administration of FS or NFS with nicotine significantly decreased the incidence of micronuclei and the percentage of sperm abnormalities as well as the expression levels of AChE gene. Moreover, nicotine-induced histological alterations were reduced by given FS or NFS with nicotine. In conclusion, nicotine-induced sperm abnormalities, chromosomal damage, and histological injuries were mitigated by administration of FS or NFS with nicotine, and thus, FS and NFS could be used as ameliorating agents against nicotine toxicity. Graphical abstract

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Peculiarities of the effect of low-dose-rate radiation simulating high-altitude flight conditions on mice in vivo

Cited by 12 publications

References 16 publications

Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors

THE STUDY OF BIOLOGICAL EFFECTS INDUCED BY ACCELERATED 12C IONS WITH AN ENERGY OF 450 MeV/N ON MICE IN VIVO

Alleviation of nicotine-induced reproductive disorder, clastogenicity, and histopathological alterations by fenugreek saponin bulk and nanoparticles in male rats

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