Peculiarities of the Composition of Peripheral Immune Cells and Cytokine Profile in Brain Structures in Mutant DISC1-L100P Mice

Альперина, Е. Л.; Gevorgyan, M. M.; Zhanaeva, S. Ya.; Lipina, Tatiana V.; Идова, Г. В.

doi:10.1007/s10517-021-05225-0

Cited by 4 publications

(1 citation statement)

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“…Another study regarding Treg cells provided supporting evidence, showing a reduced level of Treg cells when stimulated and elevated levels of proinflammatory cytokines ( 319 ). Mutant Disc1-L100P mice, a genetic model of schizophrenia, displayed an increase in CD3 + CD4 + Th cells and a decrease in CD3 + CD4 + CD25 + Treg cells ( 320 ). By contrast, mutant Disc1-Q31L mice showed an increase in CD3 + CD4 + CD25 + Treg cells ( 321 ).…”

Section: Th Cells In Neuroinflammationmentioning

confidence: 99%

Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner

Liu

Fan

et al. 2022

Front. Immunol.

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CD4+ T cells, also known as T helper (Th) cells, contribute to the adaptive immunity both in the periphery and in the central nervous system (CNS). At least seven subsets of Th cells along with their signature cytokines have been identified nowadays. Neuroinflammation denotes the brain’s immune response to inflammatory conditions. In recent years, various CNS disorders have been related to the dysregulation of adaptive immunity, especially the process concerning Th cells and their cytokines. However, as the functions of Th cells are being discovered, it’s also found that their roles in different neuroinflammatory conditions, or even the participation of a specific Th subset in one CNS disorder may differ, and sometimes contrast. Based on those recent and contradictory evidence, the conflicting roles of Th cells in multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, epilepsy, traumatic brain injury as well as some typical mental disorders will be reviewed herein. Research progress, limitations and novel approaches concerning different neuroinflammatory conditions will also be mentioned and compared.

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Section: Th Cells In Neuroinflammationmentioning

confidence: 99%