Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies

Golubeva, O. Yu.; Alikina, Yu. A.; Brazovskaya, E. Yu.; Ugolkov, Valery V.

doi:10.1016/j.clay.2019.105401

Cited by 24 publications

(14 citation statements)

References 31 publications

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“…2 However, 5-Fu is toxic to the gastrointestinal system and bone marrow cells when injected exceeding the standard dosage form. 3,4 Despite its widespread use in chemotherapy, 5-Fu's limited absorption is a serious drawback in clinical practice. 5 Thereby, frequent concentration measurements of 5-Fu are necessary to keep an adequate level of the drug in physiological uids.…”

Section: Introductionmentioning

confidence: 99%

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

et al. 2023

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Section: Introductionmentioning

confidence: 99%

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

et al. 2023

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“…Accordingly, the vacuum pumping allows the overall pressure to approach the vapor pressure of the solvent, which evaporates faster, thus leaving empty space to be filled by the guest molecules that are forced to enter and gather inside [66]. Literature reports several studies on the loading of halloysite from organic solvents by using the vacuum assisted procedure [43,67,68]. Nevertheless, the physico-chemical insights of this mechanism have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

2021

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In this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

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“…Thus, as studies of the sorption capacity of samples of synthetic aluminosilicates with different particle morphologies have shown, aluminosilicate nanosponges have a high specific surface area, as well as the ability to change the ζ potential of the surface depending on the pH of the medium, which opens up the broad prospects for their use to obtain the universal sorbents and drugs carriers. The possibility of changing the ζ potential of the surface will allow the adsorption on an aluminosilicate carrier of drugs having the form of both cations (e.g., imipramine, perphenazine, doxorubicin, and so forth) and anions in aqueous solutions (e.g., 5-fluorouracil), the adsorption of which by aluminosilicate matrices is usually difficult due to the negative surface charge of the surface . In addition, the ability to change the sign of the zeta potential of the surface of the aluminosilicate nanosponges allows us to talk about the prospects for the development on their basis of systems for targeted drug delivery parenteral administration.…”

Section: Resultsmentioning

confidence: 99%

Aluminosilicate Nanosponges: Synthesis, Properties, and Application Prospects

et al. 2021

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A simple one-step method is presented for fabricating inorganic nanosponges with a kaolinite [Al2Si2O5(OH)4] structure. The nanosponges were synthesized by the hydrothermal treatment of aluminosilicate gels in an acidic medium (pH = 2.6) at 220 °C without using organic cross-linking agents, such as cyclodextrin or polymers. The formation of the nanosponge morphology was confirmed by scanning electron microscopy, and the assignment of the synthesized aluminosilicates to the kaolinite group was confirmed by X-ray diffraction and infrared spectroscopy. The effect of the synthesis conditions, in particular, the nature (HCl, HF, NaOH, and H2O) and pH of the reaction medium (2.6, 7, and 12), as well as the duration of the synthesis (3, 6, and 12 days), on the morphology of aluminosilicates of the kaolinite group was studied. The sorption capacity of aluminosilicate nanosponges with respect to cationic (e.g., methylene blue) and anionic (e.g., azorubine) dyes in aqueous solutions was studied. The pH sensitivity of the surface ζ potential of the synthesized nanosponges was demonstrated. The dependence of the hemolytic activity (the ability to destroy erythrocytes) of aluminosilicate nanoparticles on the particle morphology (platy, spherical, and nanosponge) has been identified for the first time. Aluminosilicate nanosponges were not found to exhibit hemolytic activity. The prospects of using aluminosilicate nanosponges to prepare innovative functional materials for ecology and medicine applications, in particular, as matrices for drug delivery systems, were identified.

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Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies

Cited by 24 publications

References 31 publications

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

Aluminosilicate Nanosponges: Synthesis, Properties, and Application Prospects

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