For every nine tons of produced biodiesel, there is another ton of glycerol as a byproduct. Therefore, glycerol prices dropped significantly worldwide in recent years; the more significant biodiesel production is, the more glycerol exists as a byproduct. glycerol prices also impact the biodiesel manufacturing business, as it could be sold according to its refinement grade. The primary objective of this work was to evaluate the economic potential of the production of 1,2-propanediol derived from the biodiesel produced in Colombia. A plant to produce 1,2-propanediol via catalytic hydrogenation of glycerol in a trickle-bed reactor was designed. The plant comprised a reaction scheme where non-converted excess hydrogen was recycled, and the heat generated in the reactor was recovered. The reactor effluent was sent to a separation train where 98% m/m purity 1,2-propanediol was attained. Capital and operational costs were estimated from the process simulation. The net present value (NPV) and the modified internal return rate (MIRR) of the plant were used to assess the viability of the process. Their sensitivity to key input variables was evaluated to find the viability limits of the project. The economic potential of the 1,2-propanediol was calculated in USD 1.2/kg; for the base case, the NPV and the MIRR were USD 54.805 million and 22.56%, respectively, showing that, for moderate variations in products and raw material prices, the process is economically viable.