Peculiarities of Cytokines and Their Prognostic Value in Patients With Chronic Glomerulonephritis

Abstract

Introduction. Cytokines are important to take part in immunogenesis and progression of glomerulonephritis (GN), therefore the analysis of these indices in dependence of type of GN forms as prognosys results of treatment.
 Aim of the work is to determine the peculiarities of pro-inflammatory cytokines (TNFα, MCP-1, IL-17, -18, -23) and anti-inflammatory TGF- β1 and their association with form GN with nephritic syndrome (NS) and possibility use cytokines as prognostic markers.
 Materials and methods. Using IFA, the level of the above mentioned cytokines was studied in the blood serum of 117 patients with proliferative (33) and non-proliferative (84) CGN, NS forms. There was also analyzed the changes of these indices in the patients with subsequent clinical laboratory remission (59) and patients without one (58).
 Results. The GN, NS patients showed statistically higher level of the pro- inflammatory cytokines – TNFα, MCP-1, IL-17 (with more high indices last one in the proliferative forms of GN, and IL-17 in nonsensitive to immunotherapy patients). High level profibrogenic TGFβ, and the ratio TNFα /TGFβ reflect the prevalence of anti-inflammatory reactions and high activity of monocytes - macrophages and T-helpers17. The positive effect of the treatment associates with the statistically decreased TNFα, MCP-1 and TGFβ1 levels in the patients with proliferative forms GN; the TGFβ1 - for patients with non-proliferative GN forms.
 Conclusion. The changes cytokine profiles may be use as predictors of results the immunosuppressive therapy.

Cytokines and progressive chronic kidney disease in children

“…По мнению M. Kolesnyk и соавт. (2013) [38], изменения цитокинового профиля в виде преобладания провоспалительных цитокинов над противовоспалительными при хроническом гломерулонефрите могут быть использованы и в качестве прогнозирования результатов иммуносупрессивной терапии.…”

BOLALARDA SURUNKALI BUYRAK KASALLIGI RIVOJLANIShINING IMMUNPATOGENETIK XUSUSIYATLARI (adabiyotlar sharxi)

“…Kolesnyk M. va boshq. fikriga ko'ra, surunkali glomerulonefrit kechishi jarayonida yallig'lanishga qarshi sitokinlarga nisbatan yallig'lanishni qo'llovchi sitokinlarning ustunlik qilishini asoslovchi ko'rsatkichlar kasallikda immunsupressiv terapiya natijalarini prognoz qilishda muxim axamiyatga ega [39]. Latifova N.F va boshq.…”

“…Shu jumladan, surunkali glomerulonefrit bilan og'rigan bemorlardagi yallig'lanish jarayonida IL-8 faol ishlab chiqariladi va eng yuqori ko'rsatkichi kuzatiladi. Olingan ilmiy-tadqiqot natijalariga asoslanib, olimlar surunkali buyrak kasalliklaridagi yallig'lanish patogenezida sitokinlar va antimikrob www.ijsp.uz published: 29 Aprel 2023 2023 / Issue 04 / Article 01 peptidlarning muhim roli va ularni surunkali buyrak shikastlanishining dastlabki belgisi sifatida qo'llashning asosliligi haqida xulosa qilishgan [39,40].…”