Peculiarities of antistress proteins Hsp60 and P450 2E1 expression at dilated cardiomyopathy

Sidorik, L. L.; Bobyk, V. I.; Kyyamova, R. G.; Kapustjan, L. N.; Rozhko, O. T.; Vigontina, O. G.; Ryabenko, D. V.; Dankó, István; Maksymchuk, Oksana; Filonenko, Valeriy; Коваленко, В. Н.; Chaschin, N. A.

doi:10.7124/bc.0006c6

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Moreover, it has been reported that transcriptional suppression of CYP2C11 by LPS or IL-1 in rats is mediated at least in part by NF-B [124]. Also, NF-B was shown to have mutual func-tional repression with the AhR which is essential for CYP1A1 induction [47]. Also, NF-B was shown to have mutual func-tional repression with the AhR which is essential for CYP1A1 induction [47].…”

Section: Pro-inflammatory Cytokinesmentioning

confidence: 99%

Modulation of Cardiac and Hepatic Cytochrome P450 Enzymes During Heart Failure

Zordoky¹,

El‐Kadi

2008

CDM

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Heart failure is a very serious cardiovascular disease that affects more than five million people in North America. The role of cytochrome P450 (CYP) in cardiovascular health and disease is well established. Many CYP enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. There is a great deal of discrepancy between various reports on CYP alterations during heart failure, likely due to differences in disease severity, species in question and other underlying conditions. In general, however, cardiac CYP1B and CYP2A, CYP2B, CYP2E, CYP2J, CYP4A and CYP11 mRNA levels and related enzyme activities are usually increased. Moreover, there is a strong correlation between CYP-mediated endogenous metabolites and the pathogenesis of cardiac hypertrophy and heart failure. Some of these metabolites confer cardioprotective effect such as estradiol, dehydroepiandrosterone, epoxyeicosatrienoic acids, and prostaglandin I(2); whereas, other metabolites may be harmful to the heart such as androgens, aldosterone, hydroxyeicosatetraenoic acids, and thromboxane A(2). On the other hand, heart failure plays an important role in the down-regulation of hepatic CYP involved in drug metabolism through several mechanisms which include hepatocellular damage, hypoxia, elevated levels of pro-inflammatory cytokines, and increased production of heme oxygenase-1. Therefore, more research is needed to elucidate the mechanisms by which CYP affect the development and/or progression of heart failure and also the mechanism by which heart failure alters cardiac and hepatic CYP enzymes.

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Section: Pro-inflammatory Cytokinesmentioning

confidence: 99%