Pectolinarigenin - A Flavonoid Compound from &lt;i&gt;Cirsium Japonicum&lt;/i&gt; with Potential Anti-proliferation Activity in MCF- 7 Breast Cancer Cell

Lu, Mengji; Kong, Qing; Xu, Xiaoquan; Lu, Haojie; Lu, Zhongxin; Yu, Wenlong; Zuo, Bin; Su, Jing; Guo, Rong

doi:10.4314/tjpr.v13i2.9

Cited by 24 publications

(15 citation statements)

References 12 publications

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“…Treating the cells with 200 µg/ml of S6 and S8 resulted in no significant differences in cell proliferation ( p > 0.05). Lu et al (Lu et al, ) have reported that 50 µM of pectolinarigenin effectively suppresses the growth of MCF‐7 cells (a breast cancer cell line), and our study has shown that the extracts are not toxic to normal cells. This therefore implies that our beverage is safe for consumption and may inhibit tumor growth.…”

Section: Resultssupporting

confidence: 73%

Biological activities of a garlic–Cirsium setidens Nakai blend fermented with Leuconostoc mesenteroides

Daliri

Choi

Cho

et al. 2019

Food Science & Nutrition

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In this study, we investigated the antioxidant‐ and immune‐stimulating activities of various garlic– Cirsium setidens Nakai blends (fermented and unfermented). The levels of S‐allyl cysteine increased by 2.5 times while pectolinarigenin (an anti‐inflammatory compound) increased about six times (from 1.1 ± 0.04 mg/g to 6.70 ± 0.12 mg/g) after the garlic– Cirsium setidens Nakai (80:20%, respectively) blend (S4) was fermented with Leuconostoc mesenteroides KCTC 13302. The ferric reducing ability and DPPH radical scavenging activities of all the samples increased significantly after fermentation. Ethanolic extracts of the fermented samples significantly enhanced RAW 264.7 macrophage proliferation in a dose‐dependent manner and induced nitric oxide production. Among the samples, S6 and S8 stimulated the highest levels of nitric oxide (NO) production. S6 significantly induced proinflammatory cytokines TNF‐α and IL‐1β as well as an anti‐inflammatory cytokine IL‐10 relative to control. Since the resolution of an infection would require a harmonized interplay of proinflammatory factors and anti‐inflammatory cytokines, consumption of S6 could be helpful in promoting health.

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Section: Resultssupporting

confidence: 73%

Biological activities of a garlic–Cirsium setidens Nakai blend fermented with Leuconostoc mesenteroides

Daliri

Choi

Cho

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

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“…Previously we have already demonstrated that the flavonoid pectolinarigenin inhibits the proliferation of breast cancer cell [11]. We speculated that inhibiting CSCs properties may be a potential mechanism of preventing carcinogenesis by pectolinarigenin.…”

Section: Discussionmentioning

confidence: 95%

“…The extraction and isolation procedures had been reported previously [11]. Namely, the powdered air-dried aerial parts of C. japonicum (1 kg) were extracted three times with 6 L 80 % ethanol/10 % HCl (4:1, v/v) in a conical flask and refluxed at 80 °C for 2 h. The solvent was evaporated in vacuum and then the concentrated extract was partitioned with chloroform.…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…The isolated compound was identified by a combination of NMR and mass spectral data as reported previously [11]. Soft agar colony formation assay and tumor sphere assay have been widely used to identity stem cells in in vitro assays.…”

Section: Pectolinarigenin Inhibited Bcscs Selfrenewal Propertiesmentioning

confidence: 99%

“…Recently, we have confirmed that pectolinarigenin showed potent anti-proliferation activity by inducing apoptosis and downregulation of Bcl2 expression in MCF-7 breast cancer cell [11]. However, the effects of pectolinarigenin on breast cancer stem cell properties have rarely been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Anti-tumor and Chemoresistance-lowering Effects of Pectolinarigenin from <i>Cirsium japonicum</i> Fisch ex DC in Breast Cancer

Lu¹,

Xu²,

Lu³

et al. 2016

Trop. J. Pharm Res

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Phytochemistry and Pharmacology ofPhyllanthus niruriL.: A Review

Kaur

Sirhindi

2017

Phytotherapy Research

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Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical and subtropical regions of both hemispheres. The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiinflammatory, antiplasmodial, antiviral, diuretic and hepatoprotective. This review summarizes the information about morphological, biochemical, ethanobotanical, pharmacological, biological and toxicological activities with special emphasis on mechanism of anticancer activity of P. niruri. Gaps in previous studies such as taxonomic inconsistency of P. niruri, novel phytochemicals and their therapeutic properties, especially mechanisms of anticancerous activity and market products available, have been looked into and addressed. Scientific information related to 83 phytochemicals (including many novel compounds detected recently by the authors) has been provided in a very comprehensive manner. Copyright © 2017 John Wiley & Sons, Ltd.

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Pectolinarigenin - A Flavonoid Compound from <i>Cirsium Japonicum</i> with Potential Anti-proliferation Activity in MCF- 7 Breast Cancer Cell

Cited by 24 publications

References 12 publications

Biological activities of a garlic–Cirsium setidens Nakai blend fermented with Leuconostoc mesenteroides

Biological activities of a garlic–Cirsium setidens Nakai blend fermented with Leuconostoc mesenteroides

Evaluation of Anti-tumor and Chemoresistance-lowering Effects of Pectolinarigenin from <i>Cirsium japonicum</i> Fisch ex DC in Breast Cancer

Phytochemistry and Pharmacology ofPhyllanthus niruriL.: A Review

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