Pectin-based self-healing hydrogel with NaHCO3 degradability for drug loading and release

Chen, Danyang; Chang, Limin; Zhou, Ziwei; Bo, Yunyi; Wang, Yong; He, Yingna; Qin, Jianglei

doi:10.1007/s10965-021-02430-3

Cited by 15 publications

(13 citation statements)

References 48 publications

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“…Pectin is a hydrophilic polysaccharide that occurs naturally and is increasingly used in the pharmaceutical and biotechnology industries [27,28]. It is inexpensive, biodegradable, biocompatible, and renewable, thus encouraging researchers to investigate its possible use in industrial applications [29][30][31]. However, the low chemical resistance and microbial attack limit industrial applications of pectin.…”

Section: Introductionmentioning

confidence: 99%

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

et al. 2022

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Bio-based hydrogels (denoted as PC-PAAc/GA) comprised of Pectin (PC) and polyacrylic acid (PAAc) reinforced with different ratios of gallic acid (GA) were prepared by gamma radiation at irradiation dose 20 kGy. The prepared hydrogels were investigated by different analytical tools. The swelling performance was studied versus time, pH of the medium and gallic acid content. The experimental data depicted that the swelling increases with pH of medium until the equilibrium of swelling after 350 min. The maximum swelling was attained at pH10 for both PC-PAAc and PC-PAA/GA1.5. Also, the data reveal that the incorporation of GA in the hydrogel matrix enhanced the swelling performance of the hydrogel up to an optimum value of GA, i.e. PC-PAA/GA1.5. Further increase in GA concentration leads to formation of a highly crosslinked structure with reduced swelling. The results demonstrated that the prepared hydrogels displayed excellent antibacterial activity against gram + ve bacteria (E.coli) and gram-ve bacteria (S.aureus). This potent antimicrobial activity is mainly originated from GA which was proved as a strong antibacterial agent. Moreover, the removal performance of the investigated hydrogels was verified towards Pb+2 cation as one of the most poisonous heavy metals. The data revealed that the maximum removal percentage of Pb (II) was attained by PC-PAAc/GA1.5 hydrogel (90 mg g−1). The correlation coefficients of the Langmuir model are too higher than that of the Freundlich model that assumed the adsorption of lead cations is mainly a chemical process.

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Section: Introductionmentioning

confidence: 99%

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

et al. 2022

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“… The Nano-carriers continuous Oxaliplatin release in phosphate buffer solution at pH 5.5 and 7.4. [ 99 ] Delivery of anti-Alzheimer's drugs P/Ag NCs film Donepezil The NCs adsorption and release efficiencies were also exceptional. The drug release capacity of the NCs in phosphate buffer saline solution was determined to be 94.33 over a 5-day period.…”

Section: Pectin and Its Modified Ncs For Drug Delivery Applicationsmentioning

confidence: 99%

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Kedir¹,

Deresa²,

Diriba³

2022

Heliyon

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“…To obtain excellent self‐healing properties and higher mechanical properties simultaneously, dynamic covalent chemical cross‐linked can introduce into the dynamic physical cross‐linked hydrogel to form a double‐network self‐healing hydrogel. Among the dynamic non‐covalent bonds, the acylhydrazone bond belongs to the relatively stable combination 16,18–20 . It is formed by the condensation of hydrazide and carbonyl under weakly acidic or nucleophilic catalytic conditions 10,21 .…”

Section: Introductionmentioning

confidence: 99%

“…Among the dynamic noncovalent bonds, the acylhydrazone bond belongs to the relatively stable combination. 16,[18][19][20] It is formed by the condensation of hydrazide and carbonyl under weakly acidic or nucleophilic catalytic conditions. 10,21 Nowadays, we have constructed a hydrogel using acylhydrazone bonds and find that the prepared hydrogel can be self-healed without external stimuli.…”

mentioning

confidence: 99%

Double dynamic bonds tough hydrogel with high self‐healing properties based on acylhydrazone bonds and borate bonds

Chen

Wang

Guo

et al. 2022

Polymers for Advanced Techs

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Hydrogels with excellent self-healing properties have specific applications in smart polymer materials, but they often do not have excellent mechanical properties, or the preparation process of hydrogels is too complicated. Here, we prepared a multi-functional intelligent hydrogel using a simple water bath one-pot method through the synergistic effect of dual dynamic cross-linked agents, including acylhydrazone bonds (the first cross-linked agent) and borate ester bonds (the second cross-linked agent), at the same time hydrogen bonds provided physical interaction. The hydrogel exhibited excellent self-healing ability (up to 91%) and extraordinary mechanical strength (tensile stress 173.1405 kPa and hysteresis energy of 1.8659 MJ m À3 ). The research used chemical cross-linked (acylhydrazone bonds and borate ester bonds) and physical cross-linked (hydrogen bonds). The prepared hydrogel had the dual advantages of excellent self-healing performance and high mechanical strength. The hydrogel can be used in smart materials, such as working pressure tissues and sensing materials that require a certain degree of mechanical strength and self-healing properties, and also provides a design strategy for preparing hydrogels with high mechanical strength and excellent self-healing properties.

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Pectin-based self-healing hydrogel with NaHCO3 degradability for drug loading and release

Cited by 15 publications

References 48 publications

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

Gamma irradiation synthesis of pectin- based biohydrogels for removal of lead cations from simulated solutions

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Double dynamic bonds tough hydrogel with high self‐healing properties based on acylhydrazone bonds and borate bonds

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