Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (
            <i>Micropterus salmoides</i>
            ), which might be attributed to their BA binding capacity

Ni, Qin; Cai, Chen; Ren, Shengjie; Zhang, Junbiao; Zhao, Yi-Jun; Wei, Xinyi; Ge, Yiyang; Wang, Chengrui; Li, Wenjian; Wu, Ping; Ye, Yuantu; Cao, Xiamin

doi:10.1111/are.15140

Cited by 10 publications

(13 citation statements)

References 94 publications

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“…5). This result indicated that the binding capacity of pectin to GCBAs might be stronger than that to TCBAs and then cause higher loss of GCBAs with feces (Ni et al 2021). Consistent with the higher value of GCBAs/TCBAs in the digesta, there was a signi cant decrease in the value of GCBAs/TCBAs in the liver, serum, and bile (P < 0.05, Fig.…”

Section: Discussionmentioning

confidence: 54%

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Dietary pectin caused greatly changes in bile acid profiles of Pelteobagrus fulvidraco

Cao¹,

Ren²,

Ni³

et al. 2021

Preprint

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To reveal the impact of dietary fiber (DF) on the bile acid (BA) profiles of fish, yellow catfish (Pelteobagrus fulvidraco) were fed diet containing 300 g kg-1 dextrin (CON diet, control) or pectin (a type of soluble DF, PEC diet) for 7 days, and then the BA profiles were analyzed by UHPLC-MS/MS. A total of 26 individuals of BAs were detected in the fish body, with 8, 10, 14, and 22 individuals of BAs were detected in the liver, serum, bile and hindgut digesta, respectively. The conjugated BAs (CBAs) of fish were dominated by taurine-CBAs (TCBAs). The concentrations of free BAs (FBAs) and the values of FBAs/CBAs in the bile of fish fed the PEC diet were nearly 5 and 7 times higher, respectively, than those in fish fed the CON diet. The values of glycine-CBAs/TCBAs in the liver, serum and bile of fish fed the PEC diet were significantly lower, and in the hindgut digesta was higher than that of fish fed the CON diet (P < 0.05). These results suggested that dietary pectin greatly changed the BA profiles of Pelteobagrus fulvidraco, attributed to inhibition of reabsorption of BAs. Therefore, attention should be paid to the impact to BA homeostasis when replacing fishmeal with DF-rich plant ingredients in the fish diet.

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Section: Discussionmentioning

confidence: 54%

“…(3) DFs have a capacity to bind BAs, which varied among BAs (Ni et al, 2021;Suharoschi et al 2019). By binding BAs, DFs increased BA excretion with feces (Gunness et al 2016;Gunness and Gidley 2010;Thandapilly et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Dietary pectin caused greatly changes in bile acid profiles of Pelteobagrus fulvidraco

Cao¹,

Ren²,

Ni³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…5). This result indicated that the binding capacity of pectin to GCBAs might be stronger than that to TCBAs and then caused a higher loss of GCBAs with feces (Ni et al 2021). Coined with the higher value of GCBAs/TCBAs in the digesta, there was a significant decrease in the value of GCBAs/TCBAs in the liver, serum, and bile (P < 0.05, Figs.…”

Section: Discussionmentioning

confidence: 89%

“…3), suggested that the uptake ratio of PBAs from plasma into hepatocytes was low in fish fed PEC diet, which also contributed to the low PBAs in bile. (3) DFs have a capacity to bind BAs, which varied among BAs (Ni et al 2021;Suharoschi et al 2019). By binding BAs, DFs increase the BA excretion with feces (Gunness et al 2016;Gunness and Gidley 2010;Thandapilly et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Dietary pectin caused great changes in bile acid profiles of Pelteobagrus fulvidraco

Cao

Ren

Cai

et al. 2021

Fish Physiol Biochem

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PEC diet was significantly lower, and in the hindgut digesta was higher than that of fish fed the CON diet (P < 0.05). These results suggested that dietary pectin greatly changed the BA profiles of Pelteobagrus fulvidraco, attributed to inhibition of reabsorption of BAs. Therefore, attention should be paid to the impact on BA homeostasis when replacing fishmeal with DF-rich plant ingredients in the fish diet.

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“…Cottonseed meal (CSM) is an important plant protein source. It is widely used in feeds of different fish species, such as juvenile black sea bream ( Acanthopagrus schlegelii ) (Sun et al, 2015), juvenile black carp ( Mylopharyngodon piceus ) (Hu et al, 2015), juvenile ussuri catfish ( Pseudobagrus ussuriensis ) (Bu et al, 2017), grass carp (Hu et al, 2019), juvenile blunt snout bream ( Megalobrama amblycephala ) (Yuan et al, 2019), silver sillago ( Sillago sihama Forsskal) (Liu, Dong, et al, 2020), largemouth bass ( Micropterus salmoides ) (Ni et al, 2021) and others. However, the free gossypol contained in cottonseed meal is toxic to fish, limiting its addition in fish feed.…”

Section: Introductionmentioning

confidence: 99%

Effects of fish meal replacement with low‐gossypol cottonseed meal on the intestinal barrier of juvenile golden pompano ( Trachinotus ovatus )

Qian

Liu

et al. 2021

Aquaculture Research

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The effects of replacing fish meal (FM) with low-gossypol cottonseed meal (LCSM) on the intestinal barrier in different segments (PI, proximal intestine; MI, middle intestine; DI, distal intestine) were studied in juvenile golden pompano (Trachinotus ovatus) using 6-week feeding trials. FM of 0% (diet_1), 20% (diet_2), 40% (diet_3) and 60% (diet_4) was replaced by LCSM. The FM-based diet (diet_1) containing 25% FM was used as control group. The intestinal morphology, mRNA expression of tight junctionrelated genes (ZO-1, Occludin, Claudin-12), antioxidant enzyme-related genes (CAT, GPx, GR, CuZnSOD) and non-specific immune response-related genes (IL-8, TNFα, C4) and microbiota of different intestine segments were detected. The results showed that the number and length of microvilli and intestinal wall thickness decreased significantly in PI of diet_3 and diet_4 groups. Meanwhile, mRNA expression of Occludin, Clauding-12 and C4 was up-regulated in PI and DI of diet_3 group; the expression of GR and CuZnSOD was up-regulated in PI and MI with increasing LCSM replacement; the expression of TNFα was up-regulated in the three segments of diet_3 group. Further, 16S rRNA amplicon sequencing revealed a significant reduction in the richness and diversity of intestinal microbial in diet_3 and diet_4 groups. At the family level and genera level, the abundance of Nocardiaceae and Rhodococcus was up-regulated in the three segments of diet_3 and diet_4 groups respectively. These results suggested that the replacement of LCSM by more than 20% causes the intestinal barrier function of juvenile golden pompano to be affected. These provide a reference for sustainable aquaculture.

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Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass ( Micropterus salmoides ), which might be attributed to their BA binding capacity

Cited by 10 publications

References 94 publications

Dietary pectin caused greatly changes in bile acid profiles of Pelteobagrus fulvidraco

Dietary pectin caused greatly changes in bile acid profiles of Pelteobagrus fulvidraco

Dietary pectin caused great changes in bile acid profiles of Pelteobagrus fulvidraco

Effects of fish meal replacement with low‐gossypol cottonseed meal on the intestinal barrier of juvenile golden pompano ( Trachinotus ovatus )

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