PeaTAR1B: Characterization of a Second Type 1 Tyramine Receptor of the American Cockroach, Periplaneta americana

Blenau, Wolfgang; Balfanz, Sabine; Baumann, Arnd

doi:10.3390/ijms18112279

Cited by 11 publications

(22 citation statements)

References 107 publications

(167 reference statements)

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“…TyrRI is homologous to vertebrate a 2 -adrenoceptors ) and may exhibit agonist-dependent coupling, since TYR was reported to induce adenylyl cyclase inhibition (Vanden Broeck et al, 1995;Blenau and Baumann, 2001), whereas OCT induces an increase in cytosolic Ca 2+ (Robb et al, 1994;Evans and Maqueira, 2005;Beggs et al, 2011). A second TyrRI isoform was very recently reported in the cockroach (Blenau et al, 2017).…”

Section: Tyramine Receptorsmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

282

287

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Section: Tyramine Receptorsmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

282

287

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“…Our phylogenetic analysis ( Figure 2 ) was made using complete amino acid sequences but results are largely similar to previous reports using trimmed sequences (e.g., Dacks et al, 2013 ; Bauknecht and Jekely, 2017 ; Reim et al, 2017 ). As in previous studies, the basal branching of the subgroups was poorly supported by the bootstrap values, indicating that the relationships of biogenic amine receptors should be further investigated ( Dacks et al, 2013 ; Spielman et al, 2015 ; Blenau et al, 2017a ). However, all C. salei sequences were in highly supported clusters with other receptors in protostomes, most with sister groups to sequences in deuterostomes.…”

Section: Discussionmentioning

confidence: 51%

“…Mianserin is the most efficient blocker of insect OAβ receptors ( Maqueira et al, 2005 ; Balfanz et al, 2014 ) but it also inhibits other types of OA and TA receptors ( Gross et al, 2015 ; Bauknecht and Jekely, 2017 ; Blenau et al, 2017a , b ; Reim et al, 2017 ). When 10 μM mianserin was added to the spider VS-3 neuron superfusion, OA and TA induced increases in spike rate were significantly reduced in all neurons tested and recovered only slightly after wash ( Figures 5A1,A2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The biogenic amines histamine (HA), dopamine (DA), and serotonin (5-HT) are common neurotransmitters in both vertebrates and invertebrates, but adrenergic signaling has been considered absent in protostome invertebrates, where monoamine octopamine (OA) and its precursor tyramine (TA) have replaced noradrenaline and adrenaline ( Roeder, 2005 ; Lange, 2009 ; Ohta and Ozoe, 2014 ; Blenau et al, 2017a , b ). Biogenic amines act mainly on G-protein coupled receptors (GPCRs) and arthropod receptors are classified based on similarities in their molecular structures and signaling pathways to their vertebrate counterparts ( Evans and Maqueira, 2005 ; Verlinden et al, 2010 ; Ohta and Ozoe, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Multiple Biogenic Amine Receptor Types Modulate Spider, Cupiennius salei, Mechanosensory Neurons

et al. 2018

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The biogenic amines octopamine (OA), tyramine (TA), dopamine (DA), serotonin (5-HT), and histamine (HA) affect diverse physiological and behavioral processes in invertebrates, but recent findings indicate that an additional adrenergic system exists in at least some invertebrates. Transcriptome analysis has made it possible to identify biogenic amine receptor genes in a wide variety of species whose genomes have not yet been sequenced. This approach provides new sequences for research into the evolutionary history of biogenic amine receptors and allows them to be studied in experimentally accessible animal models. The Central American Wandering spider, Cupiennius salei, is an experimental model for neurophysiological, developmental and behavioral research. We identified ten different biogenic amine receptors in C. salei transcriptomes. Phylogenetic analysis indicated that, in addition to the typical receptors for OA, TA, DA, and 5-HT in protostome invertebrates, spiders also have α1- and α2-adrenergic receptors, but lack TAR2 receptors and one invertebrate specific DA receptor type. In situ hybridization revealed four types of biogenic amine receptors expressed in C. salei mechanosensory neurons. We used intracellular electrophysiological experiments and pharmacological tools to determine how each receptor type contributes to modulation of these neurons. We show that arachnids have similar groups of biogenic amine receptors to other protostome invertebrates, but they lack two clades. We also clarify that arachnids and many other invertebrates have both α1- and α2-adrenergic, likely OA receptors. Our results indicate that in addition to an OAβ-receptor that regulates rapid and large changes in sensitivity via a Gs-protein activating a cAMP mediated pathway, the C. salei mechanosensory neurons have a constitutively active TAR1 and/or α2-adrenergic receptor type that adjusts the baseline sensitivity to a level appropriate for the behavioral state of the animal by a Gq-protein that mobilizes Ca2+.

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“…Tyramine receptors have been identified in numerous invertebrate species, including fruit flies ( Saudou et al 1990 ), honeybees ( Blenau et al 2000 ) and cockroaches ( Blenau et al 2017 ), suggesting that tyramine’s role as a neurotransmitter extends beyond C. elegans . Like SER-2 , each of these receptors also has a putative methylation motif within its third intracellular loop (Figure S1), suggesting that methylation may regulate tyraminergic signaling across multiple phyla.…”

Section: Discussionmentioning

confidence: 99%

The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors inCaenorhabditis elegans

Bowitch

Michaels

et al. 2018

G3 Genes|Genomes|Genetics

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G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli. Understanding the mechanisms that regulate G protein-coupled receptors is crucial to manipulating their signaling for therapeutic benefit. One key regulatory mechanism that contributes to the functional diversity of many signaling proteins is post-translational modification. Whereas phosphorylation remains the best studied of such modifications, arginine methylation by protein arginine methyltransferases is emerging as a key regulator of protein function. We previously published the first functional evidence that arginine methylation of G protein-coupled receptors modulates their signaling. We report here a third receptor that is regulated by arginine methylation, the Caenorhabditis elegans SER-2 tyramine receptor. We show that arginines within a putative methylation motif in the third intracellular loop of SER-2 are methylated by PRMT5 in vitro. Our data also suggest that this modification enhances SER-2 signaling in vivo to modulate animal behavior. The identification of a third G protein-coupled receptor to be functionally regulated by arginine methylation suggests that this post-translational modification may be utilized to regulate signaling through a broad array of G protein-coupled receptors.

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PeaTAR1B: Characterization of a Second Type 1 Tyramine Receptor of the American Cockroach, Periplaneta americana

Cited by 11 publications

References 107 publications

Trace Amines and Their Receptors

Trace Amines and Their Receptors

Multiple Biogenic Amine Receptor Types Modulate Spider, Cupiennius salei, Mechanosensory Neurons

The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors inCaenorhabditis elegans

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