Pearly Penile Papules

Glicksman, Joseph M.; Freeman, Robert G.

doi:10.1001/archderm.1966.01600190062012

Cited by 33 publications

(7 citation statements)

References 3 publications

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“…Isolated angiofibromas are not uncommon in adults [Elifritz et al, 2008] but are not common in children or in large numbers. Few cases of individuals with earlier onset and larger numbers of lesions have been reported [Hall et al, 2007; Elifritz et al, 2008]. We report on four healthy patients who appear to have isolated, multiple facial angiofibromas of childhood onset, without further evidence of any disease‐associated syndrome.…”

Section: Introductionmentioning

confidence: 78%

Absence of signs of systemic involvement in four patients with bilateral multiple facial angiofibromas

Hunter

Nezarati

Velsher

2010

American J of Med Genetics Pt A

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Facial angiofibromas are a major diagnostic sign for tuberous sclerosis (TS) and MEN1, and the former is probably the first disease to be considered by a geneticist when such lesions are found. They occur in up to 90% of persons with TS and 40-80% of individuals with MEN1. Early onset facial angiofibromas that are not associated with any other systemic sign appear to be unusual, and their occurrence can leave the clinician with some uncertainty as to their significance, as well as how to proceed. In this article we describe four patients with what appear to be isolated, bilateral facial angiofibromas. We discuss the significance of these lesions with respect to the conditions in which they have been seen, review prior reports of apparently isolated angiofibromas, and provide some rough calculations as to how likely it would be for an underlying systemic condition to be overlooked after different levels of investigation have been performed. We also look at some aspects of the financial cost/benefit ratio of further investigation of TS beyond a clinical examination.

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Section: Introductionmentioning

confidence: 78%

Absence of signs of systemic involvement in four patients with bilateral multiple facial angiofibromas

Hunter

Nezarati

Velsher

2010

American J of Med Genetics Pt A

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“…Given the absence of corresponding sequences from Neandertals and Denisovans, the characteristic human deletion likely arose more than 800,000 years ago and potentially prior to the origin of the Homo lineage from ancestral hominids. While the penile spine/vibrissa enhancer is deleted in all humans examined, various reports indicate 15-50% of human males develop small white growths on the penis [9,21]. Though the causes of these benign growths are still unknown, their histological structure is distinct from the innervated keratinized spines found in non-human primates.…”

Section: Discussionmentioning

confidence: 99%

A Penile Spine/Vibrissa Enhancer Sequence Is Missing in Modern and Extinct Humans but Is Retained in Multiple Primates with Penile Spines and Sensory Vibrissae

et al. 2013

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Previous studies show that humans have a large genomic deletion downstream of the Androgen Receptor gene that eliminates an ancestral mammalian regulatory enhancer that drives expression in developing penile spines and sensory vibrissae. Here we use a combination of large-scale sequence analysis and PCR amplification to demonstrate that the penile spine/vibrissa enhancer is missing in all humans surveyed and in the Neandertal and Denisovan genomes, but is present in DNA samples of chimpanzees and bonobos, as well as in multiple other great apes and primates that maintain some form of penile integumentary appendage and facial vibrissae. These results further strengthen the association between the presence of the penile spine/vibrissa enhancer and the presence of penile spines and macro- or micro- vibrissae in non-human primates as well as show that loss of the enhancer is both a distinctive and characteristic feature of the human lineage.

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“…In both cases, the glans of the penis was prepped and anesthetized locally with 1% lidocaine. Using a defocused beam approximating the diameter of each papule, each individual lesion was treated with the CO 2 laser set at 0.1 seconds and 5 W (per pulse power density of 640–160 W/cm 2 and an energy fluence of 64–16 J/cm 2 ) (Fig. 2).…”

Section: Case Reportmentioning

confidence: 99%

“…The incidence has been reported in the range of 8%–30% 2,4–6 . No difference in occurrence has been noted between races, with a greater percentage of uncircumcised men demonstrating this condition.…”

Section: Introductionmentioning

confidence: 99%

“…Pearly penile papules are normal skin‐colored, white or red, smooth and dome‐shaped papules, which are 1–3 mm in diameter and 1–4 mm in length. They are located circumferentially over the corona and sulcus of the glans penis and are arranged in one or several rows 1,2 . Histologically, they are characterized by fibrosis and angiomatous proliferation and are considered to be acral angiofibromas 3 …”

Section: Introductionmentioning

confidence: 99%

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