Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force

Cox, Linda; Williams, Brock A; Sicherer, Scott H.; Oppenheimer, John; Sher, Larry; Hamilton, Robert G.; Golden, David B.K.

doi:10.1016/s1081-1206(10)60220-7

Cited by 183 publications

(126 citation statements)

References 47 publications

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“…Although, most of evaluations of performance of MAST assays were performed compared to allergen skin test [6,[13][14][15][16], comparisons with ImmunoCAP assay have been performed [5,8,17] considering the limitation of allergen skin test as a reference method due to the difference of principle of in vivo test from in vitro test [1]. ImmunoCAP assay has been known to have established performance [2].…”

Section: Discussionmentioning

confidence: 99%

“…For the diagnosis of allergy, presence of allergen-speci�c immunoglobulin E (IgE) is usually established either by in vivo allergen skin tests or by in vitro allergen-speci�c IgE measurements [1,2]. Although, in vivo skin test has been widely used to detect allergen-speci�c IgE.…”

Section: Introductionmentioning

confidence: 99%

“…It is not a quantitative test and is difficult to be standardized [3]. erefore, detection of allergen-speci�c IgE is important for the diagnosis of allergy [1,2]. Since the development and improvement of �uorescent enzyme immunoassay, the ImmunoCAP system (Pharmacia Diagnostics AB, Uppsala, Sweden) has been widely accepted as a reference method of allergen-speci�c IgE measurement because of its reliability, reproducibility, and good accordance with allergen skin test.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Multiple Allergen Simultaneous Test and ImmunoCAP for the Diagnosis of Allergic Rhinitis

Do-Youn¹,

Park²,

Hong³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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). Forty sera that tested positive with the RIDA Allergy Screen (20 for food and 20 for inhalant panel) were subjected to MAST Optigen and Polycheck Allergy. For 26 available sera with discrepant results, 62 ImmunoCAP allergen-speci�c IgE tests (Pharmacia Diagnostics, Uppsala, Sweden) were performed. Percent agreements (kappa value) were 87.6% (0.59) and 91.3% (0.60) between RIDA and MAST; 89.9% (0.55) and 88.3% (0.46) between RIDA and Polycheck; and 86.8% (0.51) and 90.6% (0.61) between MAST and Polycheck. Compared with ImmunoCAP, agreements (kappa value) of inhalant and food panels were 51.7% (0.04) and 33.3% (−0.38) for RIDA; 60.7% (0.27) and 81.8% (0.59) for MAST; and 65.5% (0.26) and 45.5% (0.07) for Polycheck. e agreements between RIDA, MAST, and Polycheck and ImmunoCAP-positivity were 45.7%, 88.2%, and 28.6%, respectively, and the agreements for ImmunoCAP-negativity were 37.0%, 51.9%, and 88.9%. MAST Optigen showed better agreement with ImmunoCAP than other assays in the food panel. Better sensitivity of MAST Optigen and better speci�city of Polycheck Allergy were suspected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Multiple Allergen Simultaneous Test and ImmunoCAP for the Diagnosis of Allergic Rhinitis

Do-Youn¹,

Park²,

Hong³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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“…Итак, повышение суммарного количества IgE-антител обнаруживают при аллергопатологии (ато-пический дерматит, бронхиальная астма, аллергиче-ский ринит, ангионевротический отек, крапивница), при гельминтозах, и редко при различной патологии иммунной системы (гипер-IgE-синдром, миелома, бронхолегочный аспергиллез), в том числе и аутоим-мунной патологии, такой как ревматоидный артрит, системная красная волчанка, псориаз [16,19]. В табл.…”

Section: механизм взаимодействия Ige-антитела с Fcεr-рецеп-торомunclassified

“…Согласно лаборатор-ным стандартам ВОЗ 1 МЕ/мл (МЕ -международ-ная единица) соответствует 2,4 нг/мл иммуноглобу-лина Е. Концентрацию IgE определяют либо в МЕ/ мл, либо в кЕ/л (кЕ/л -килоединица). Сравнитель-ные исследования воспроизводимости, чувстви-тельности и специфичности определения уровня общего IgE на автоматизированных тест-системах ImmunoCap (ThermoFisher, «Phadia»), Immulite («Siemens»), двух ведущих компаний, специализи-рующихся на диагностике аллергии, продемонстри-ровали полное совпадение результатов тестов и со-ответствие стандарту 75/502 [15][16][17][18].…”

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Diagnostic value of serum total IgE the primary marker of allergic diseases

Mokronosova¹

2015

Lab. sluzh.

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Ключевые слова: иммуноглобулин е, IgE-опосредованная патология, анти-IgE терапия.Discovery of immunoglobulin e in 1967-1968 belongs to Johansson sGO and ishizaka K. the concentration of ige in the serum is 0.05% of all immunoglobulins. molecule ige binds to Fcεr receptor on the surface of mast cells and basophils. the triggering of the mast cells's activation due to contact of the ige molecule with the receptor is the basic mechanism of most common allergic reactions characterized by an immediate type hyperreactivity. serum total ige -is an important diagnostic marker which is used to screen for atopic diseases , the diagnosis of helminthiasis and various immune diseases. the level of total immunoglobulins is used as the primary marker when assigning and monitoring the anti-ige therapy.

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Evidence-Based Evaluation for Allergies to Avoid Inappropriate Testing, Diagnosis, and Treatment

Huston

Cox

2014

JAMA Intern Med

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Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force

Cited by 183 publications

References 47 publications

Comparison of Multiple Allergen Simultaneous Test and ImmunoCAP for the Diagnosis of Allergic Rhinitis

Comparison of Multiple Allergen Simultaneous Test and ImmunoCAP for the Diagnosis of Allergic Rhinitis

Diagnostic value of serum total IgE the primary marker of allergic diseases

Evidence-Based Evaluation for Allergies to Avoid Inappropriate Testing, Diagnosis, and Treatment

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