Pearls and Pitfalls in Diagnosis and Management of Coats Disease

Grosso, Andrea; Pellegrini, Marco; Cereda, Matteo Giuseppe; Panico, Claudio; Staurenghi, Giovanni; Sigler, Eric J.

doi:10.1097/iae.0000000000000485

Cited by 52 publications

(31 citation statements)

References 78 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 Histopathologic examinations have revealed macrophages in the subretinal space and increased vascular permeability caused by these cells, in addition to increased expression of VEGF, which leads to angiogenesis. 22 Administering 1.25 mg intravitreal bevacizumab before conventional treatments like laser coagulation and cryotherapy has been shown to positively influence visual outcomes. 18 Villegas et al 19 applied intravitreal bevacizumab and laser photocoagulation to 24 advanced stage Coats’ patients with exudative retinal detachment and observed regression of the exudative retinal detachment in all cases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Follow-Up and Treatment Results in Coats’ Disease

Cebeci

Bayraktar

Yılmaz

et al. 2016

tjo

View full text Add to dashboard Cite

Objectives:The aim of this study was to evaluate the clinical features, follow-up and treatment results of patients diagnosed with Coats’ disease.Materials and Methods: Medical records of 27 patients diagnosed with Coats’ disease in our clinic were reviewed retrospectively. All patients underwent complete ophthalmological examination and fundus photography was taken. Disease stage and treatment methods used were recorded.Results:Twenty-seven eyes of 27 patients were included in the study. Mean age was 9.03 years; 21 patients were male and 6 were female. Three patients were older than 18 years old. Based on the Shields classification, 1 (3.7%) eye was stage 2A, 4 (14.8%) eyes were stage 2B, 6 (22.2%) were stage 3A1, 3 (11.1%) were stage 3A2, 1 (3.7%) was stage 3B, 4 (14.8%) were stage 4 and 8 (29.6%) were stage 5. Fourteen patients underwent treatment, 12 of whom had combined therapy. The most common treatment modalities were laser photocoagulation and cryotherapy. Encircling band was done in one patient and pars plana vitrectomy in 3 patients. Enucleation was done in 5 patients.Conclusion:Coats’ disease is a chronic disease and main goal of treatment is to eliminate the vascular anomalies and their complications using repetitive combination therapies. Treatment in the early stages can lead to functional success, and in advanced stages can result in a salvageable eye.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Follow-Up and Treatment Results in Coats’ Disease

Cebeci

Bayraktar

Yılmaz

et al. 2016

tjo

View full text Add to dashboard Cite

show abstract

“…Untreated Coats' disease leads to loss of vision due to exudative retinal detachment, with 10% of patients developing secondary neovascular glaucoma [1]. Early diagnosis and treatment help preserve functional visual acuity [2–4]. Coats' disease is diagnosed mostly in children under 10 years of age.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Monitoring Coats’ Disease

Hautz

Gołębiewska

Kocyła-Karczmarewicz

2017

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. The aim of this study was to evaluate the usefulness of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in monitoring pediatric patients with Coats' disease. Material and Methods. This retrospective study included 9 Caucasian patients receiving treatment for Coats' disease at the Children's Memorial Health Institute Ophthalmology Department between December 2014 and May 2016. The course of the disease was monitored with OCTA in combination with OCT and fluorescein angiography (FA). Results. OCT B-scans obtained in all patients correlated with FA findings. Reliable OCTA images were obtained in 8 patients. In one patient, numerous artifacts due to poor visual acuity and retinal detachment confounded the interpretation of findings. Conclusions. OCTA and OCT, in combination with FA, are useful in Coats' disease diagnostics and treatment monitoring. As noninvasive methods, OCT and OCTA may be performed more often than FA, which enable precise monitoring of the disease and making decisions as to its further treatment.

show abstract

“…Historically, idiopathic Coats disease was considered a unilateral condition, but there is emerging evidence, from widefield imaging studies, to suggest that retinal vascular changes involve the fellow eye more frequently than originally reported. 8 Blair et al 11 retrospectively evaluated FA from the fellow eye of children with Coats disease and found that 69% of cases demonstrated retinal vascular abnormalities and/or peripheral nonperfusion. Similarly, Coats reaction in the context of systemic and genetically predetermined diseases may present with unilateral or bilateral features and can only be reliably stratified using appropriate multimodal imaging.…”

Section: Discussionmentioning

confidence: 99%

“…8 The development of abnormal retinal vascularization in these syndromes is most likely due to dysregulation of upstream and downstream signaling pathways involved in angiogenesis. For example, mutations of the NEMO gene in incontinentia pinterferes with NFkB signaling which controls the expression of genes required for angiogenesis in vascular endothelial cells.…”

Section: Discussionmentioning

confidence: 99%