Peanut seed storage proteins are responsible for clinical reactivity in Spanish peanut‐allergic children

Pedrosa, María; Boyano-Martínez, Teresa; García-Ara, Maria Carmen; Caballero, Teresa; Quirce, Santiago

doi:10.1111/j.1399-3038.2012.01337.x

Cited by 35 publications

(45 citation statements)

References 28 publications

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“…However, we did not find any differences for anaphylaxis or urticaria/angioedema. Our data agree with previous studies (28,47), although one study has shown anaphylaxis to be more highly associated with Ara h 2 (48).…”

Section: Discussionsupporting

confidence: 93%

“…Ara h 9 is more prevalent in the population studied here and appears to play an important role in peanut allergy among patients from the Mediterranean area (17,18). Ara h 2 has been implicated in other populations (28,(43)(44)(45). For example, the work of Vereda et al (19) showed that Ara h 2 was recognised by 42% of patients with peanut allergy.…”

Section: Discussionmentioning

confidence: 58%

“…For example, peanut allergic children and adults have shown differences in allergen molecular recognition, with Ara h 2 the most prevalent in children (28) and Ara h 9 in adults (18). It is known that Ara h 9 sensitization is due to cross reactivity with Pru p 3, both LTPs (19,29).…”

Section: Introductionmentioning

confidence: 99%

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Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

García-Blanca

Aranda

Blanca‐López

et al. 2015

Pediatric Allergy Immunology

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Background Peanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen. Methods Peanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3. Results Of 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty‐eight percent had Ara h 2‐ and/or Ara h 9‐specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to Artemisia between groups. IgE response to Ara h 2 was more frequent in Group A, and Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age. Conclusion Peanut allergy is frequent in subjects with allergy to plant foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients, Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

García-Blanca

Aranda

Blanca‐López

et al. 2015

Pediatric Allergy Immunology

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“…All but 1 of the patients who were sensitized to Ara h 2 and Ara h 6 showed concomitant sensitization to Ara h 1 and/or Ara h 3. Our findings are in line with others showing that Ara h 2 is the most important peanut allergen [1,2,3,4,5,6,11,21,22]. Data about the prevalence and diagnostic value of Ara h 6 are rare, but in accordance with our results two studies showed that both peanut 2S albumins are recognized by IgE from the same patients in almost all cases and that the diagnostic accuracy of IgE specific to Ara h 6 in adults is as good as for Ara h 2 [1,7].…”

Section: Discussionsupporting

confidence: 81%

“…The peanut seed storage proteins Ara h 1, Ara h 2, Ara h 3 and Ara h 6 are largely recognized as the major allergens in patients who are primarily sensitized to peanut. Among them, Ara h 2 has been described as the most important peanut allergen, with a sensitization rate of 42-100% depending on the study population, whereas the sensitization rate to Ara h 1 and Ara h 3 is lower, in the range of 30-80 and 16-61%, respectively [1,2,3,4,5,6]. The diagnostic value of Ara h 6, which has only recently become available on ImmunoCAP ISAC, has been shown to be equivalent to Ara h 2 with a positive predictive value of 95% [7].…”

Section: Introductionmentioning

confidence: 99%

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

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Background: Peanut allergy develops after primary sensitization to peanut allergens and/or IgE cross-sensitization with homologous allergens from various plants. Therefore, heterogeneous patterns of sensitization to individual peanut allergens are observed in different countries. The aim of this study was to examine the IgE sensitization patterns of Austrian peanut-allergic patients. Methods: Sera from 65 peanut-allergic patients and 20 peanut-tolerant atopics were obtained in four Austrian allergy clinics.Sensitization patterns against peanut allergens Ara h 1-3, 6, 8 and 9 were identified by ImmunoCAP and ImmunoCAP ISAC. Results: Austrian peanut-allergic patients were sensitized to Ara h 2 and 6 (71%), followed by Ara h 1 (62%), Ara h 8 (45%), Ara h 3 (35%) and Ara h 9 (11%). All sera containing Ara h 2-specific IgE were also positive for Ara h 6, with Ara h 6-specific IgE levels significantly (p < 0.05) higher compared with Ara h 2. Twelve percent displayed IgE reactivity exclusively to Ara h 8. Peanut extract and Ara h 8 showed low diagnostic specificities of 25 and 10%, respectively. The other peanut allergens showed 100% specificity. Diagnostic sensitivities determined by ImmunoCAP ISAC and ImmunoCAP were highly similar for Ara h 2, 3 and 8. Conclusions: Themajority of symptomatic peanut-allergic patients are sensitized to Ara h 2 and Ara h 6. In peanut-symptomatic patients with additional birch pollen allergy, other peanut allergens, especially Ara h 8, should be tested when IgE reactivity to Ara h 2 is absent.

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In VitroDiagnostic Methods in the Evaluation of Food Hypersensitivity

Hamilton¹

2013

Food Allergy

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Peanut seed storage proteins are responsible for clinical reactivity in Spanish peanut‐allergic children

Abstract: In our population, peanut-allergic children were mainly sensitive to SSP. A few patients were also sensitive to some nsLTPs. No differences were shown in other pan-allergens.

Cited by 35 publications

References 28 publications

Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

Influence of age on IgE response in peanut‐allergic children and adolescents from the Mediterranean area

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

In VitroDiagnostic Methods in the Evaluation of Food Hypersensitivity

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