Peanut component Ara h 8 sensitization and tolerance to peanut

Asarnoj, Anna; Nilsson, Caroline; Lidholm, Jonas; Glaumann, Susanne; Östblom, Eva; Hedlin, Gunilla; Hage, Marianne van; Lilja, G.; Wickman, Magnus

doi:10.1016/j.jaci.2012.05.019

Cited by 131 publications

(92 citation statements)

References 35 publications

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“…Consequently, high sensitization rates to Ara h 8 were primarily found in patients allergic to Fagales tree pollen such as birch in Central and Northern Europe (65-70%) [2,3,5] or alder in Japan (42%) [6]. Ara h 8 sensitization usually indicates tolerance to peanuts or occasionally only causes mild oral symptoms [14]. Sensitization rates to profilin among peanut-sensitized patients were reported to be 3.3% in the USA, 9-16% in Northern and Central Europe, and 24% in Spain [5,11].…”

Section: Introductionmentioning

confidence: 99%

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

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Background: Peanut allergy develops after primary sensitization to peanut allergens and/or IgE cross-sensitization with homologous allergens from various plants. Therefore, heterogeneous patterns of sensitization to individual peanut allergens are observed in different countries. The aim of this study was to examine the IgE sensitization patterns of Austrian peanut-allergic patients. Methods: Sera from 65 peanut-allergic patients and 20 peanut-tolerant atopics were obtained in four Austrian allergy clinics.Sensitization patterns against peanut allergens Ara h 1-3, 6, 8 and 9 were identified by ImmunoCAP and ImmunoCAP ISAC. Results: Austrian peanut-allergic patients were sensitized to Ara h 2 and 6 (71%), followed by Ara h 1 (62%), Ara h 8 (45%), Ara h 3 (35%) and Ara h 9 (11%). All sera containing Ara h 2-specific IgE were also positive for Ara h 6, with Ara h 6-specific IgE levels significantly (p < 0.05) higher compared with Ara h 2. Twelve percent displayed IgE reactivity exclusively to Ara h 8. Peanut extract and Ara h 8 showed low diagnostic specificities of 25 and 10%, respectively. The other peanut allergens showed 100% specificity. Diagnostic sensitivities determined by ImmunoCAP ISAC and ImmunoCAP were highly similar for Ara h 2, 3 and 8. Conclusions: Themajority of symptomatic peanut-allergic patients are sensitized to Ara h 2 and Ara h 6. In peanut-symptomatic patients with additional birch pollen allergy, other peanut allergens, especially Ara h 8, should be tested when IgE reactivity to Ara h 2 is absent.

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Section: Introductionmentioning

confidence: 99%

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

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“…У обоих детей кроме анафилаксии были зафикси-рованы оральный аллергический синдром, бронхо-спазм, отеки лица различной степени выраженности при экспозиции данного продукта. В этой связи не-обходимо отметить, что по данным A. Azarnoy моно-сенсибилизация к аллергену арахиса Ara h8 прояв-ляется только оральным аллергическим синдромом [12]. У одного ребенка (из группы анафилаксии) была выявлена моносенсибилизация к аллергену rAra h1.…”

Section: результаты и обсуждениеunclassified

“…Полученные результаты несколько отличаются от данных европейских исследователей [11,12], ко-торые описывают ключевую роль в развитии анафи-лаксии у детей рекомбинантных аллергенов rAra h1, rAra h2 и rAra h3. Так, сенсибилизация к аллергену арахиса rAra h2 в Европе среди пациентов детского возраста составляет более 60% и является ключевым маркером аллергических реакций к арахису [14][15][16].…”

Section: результаты и обсуждениеunclassified

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

Шуляева¹,

Пампура²,

Окунева³

2016

Ross. vestn. perinatol. pediatr.

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“…However, in the case of birch pollen allergic patients, Ara h 8 is more significant due to its cross-reactivity with Bet v 1 (Mittag et al, 2004). Interestingly, isolated Ara h 8 sensitization was suggested as being associated with no or mild symptoms among peanutsensitized patients (Asarnoj et al, 2012;Glaumann et al, 2013;Klemans et al, 2014). However, severe reactions have been reported with Ara h 8 recognition by IgE.…”

Section: Pathogenesis Related Class 10 (Pr-10) Proteinsmentioning

confidence: 99%

Structural Biology of Peanut Allergens

Offermann¹,

Perdue²,

He³

et al. 2015

JCI

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Peanuts are a cause of one of the most common food allergies. Allergy to peanuts not only affects a significant fraction of the population, but it is relatively often associated with strong reactions in sensitized individuals. Peanut and tree nut allergies, which start in childhood are often persistent and continue through life, as opposed to other food allergies that resolve with age. Therefore, peanut allergens are one of the most intensively studied food allergens. In this review we focus on the structural studies of peanut allergens.

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Peanut component Ara h 8 sensitization and tolerance to peanut

Cited by 131 publications

References 35 publications

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

Structural Biology of Peanut Allergens

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