Peamacléine Pru p 7 : épidémiologie, implications cliniques et place dans le diagnostic moléculaire de l’allergie à la pêche en région méditerranéenne

Abstract

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Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy

“…We have previously described a ubiquitous co‐sensitization to CP in Pru p 7 sensitized individuals . Among the 171 Pru p 7 sensitized subjects in the present study, all but one, who had Pru p 7 IgE at the positivity threshold of the assay (0.10 kU A /L), were also sensitized to CP.…”

“…Indeed, we found that Pru p 7 sensitization was associated with reactions to an array of plant foods, including but not limited to Rosaceae . Members of the GRP family are widely distributed in the plant kingdom, share high levels of sequence identity and have been associated with particularly severe food allergic reactions in at least three environments: Italy, France and Japan …”

“…Sensitization to nsLTPs, either as primary food allergy or as PFS, accounts for most of PA cases in the Mediterranean region . However, some PA patients have been found to lack sensitization to Pru p 1 (PR‐10), Pru p 3 (nsLTP) and Pru p 4 (profilin), despite a convincing clinical history and a strongly positive skin test with fresh peach . Pru p 7, also referred to as peamaclein, a member of the gibberellin‐regulated protein (GRP) family, was described as a novel peach allergen .…”

“…Pru p 7, also referred to as peamaclein, a member of the gibberellin‐regulated protein (GRP) family, was described as a novel peach allergen . We have previously reported Pru p 7 as a major allergen associated with severe clinical symptoms and strong cypress pollen (CP) sensitization in PA patients from Marseille, southern France . As France comprises a wide spectrum of geographic and climatic conditions, including continental, oceanic, Mediterranean and alpine regions, a variety of pollen sensitizations may occur across the country, making a fuller understanding of different pollen‐related food allergies particularly relevant.…”

Syndrome allergique pollen-fruit : actualités sur les allergènes impliqués

“…Cup s 7 et Pru p 7 sont à l'origine de réactions croisées permettant d'expliquer les syndromes cyprès-pêche et cyprès-agrumes [35,36]. La sensibilisation au seul allergène Pru p 7 de la pêche est retrouvée chez plus de la moitié des patients allergiques à la pêche et est associée à une exposition au pollen de cyprès méditerranéen (Cupressus sempervirens) [37]. De plus les expériences d'inhibition réciproque et de stimulation ex vivo des polynucléaires basophiles de patients allergiques sont en faveur d'un rôle déterminant de la pollinose au cyprès dans l'allergie sévère à la pêche [38].…”