Peak visual gamma frequency is modified across the healthy menstrual cycle

Sumner, Rachael L.; McMillan, Rebecca; Shaw, Alexander D; Singh, Krish Devi; Sundram, Frederick; Muthukumaraswamy, Suresh

doi:10.1002/hbm.24069

Cited by 33 publications

(28 citation statements)

References 94 publications

(188 reference statements)

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“…Estrus related interneuron activity might act synergistically with changes in GABAergic receptor expression, as previously reported [58], and these periodic changes in the tone of cortical inhibition might also contribute to the periodic occurrence of epilepsy in the menstrual cycle [7,8]. The well-established role of PV interneurons in cortical gamma oscillations [59][60][61] also suggests a potential functional role for estrus-dependent interneuron cycling, an idea that may be supported by recordings of gamma oscillations across the menstrual cycle in humans [62]. Furthermore, the observed shift in evoked inhibitory latency with estrus may have profound consequences for temporal integration and coding of incoming sensory stimuli [63].…”

Section: The Balance Of Excitation and Inhibitionsupporting

confidence: 53%

Estrus-Cycle Regulation of Cortical Inhibition

et al. 2019

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Graphical AbstractHighlights d Fast-spiking interneurons are strongly activated with social facial touch in rats d Fast-spiking neuron firing is regulated by the estrus cycle and estrogen d Esr2 is expressed in cortical parvalbumin neurons and is regulated by estrus d Excitability of PV neurons is mediated by an estrogen receptor b (Esr2) mechanism Correspondence michael.brecht@bccn-berlin.de In BriefClemens et al. perform in vivo and in vitro electrophysiology in barrel cortex of female rats. Fast-spiking neurons are strongly activated with social touch and vary their firing with the estrus cycle and estradiol. Estrogen acts locally to increase cortical fast-spiking neuron excitability with an estrogen receptor b (Esr2) mechanism. SUMMARYFemale mammals experience cyclical changes in sexual receptivity known as the estrus cycle. Little is known about how estrus affects the cortex, although alterations in sensation, cognition and the cyclical occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus cycle potently altered cortical inhibition. Fast-spiking interneurons were strongly activated with social facial touch and varied their ongoing activity with the estrus cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change. In situ hybridization for estrogen receptor b (Esr2) showed co-localization with parvalbuminpositive (PV + ) interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings. The fraction of neurons positive for estrogen receptor b (Esr2) and PV co-localization (Esr2 + PV + ) in cortical layer V was increased in proestrus. In vivo and in vitro experiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen-receptorb-dependent mechanism.

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Section: The Balance Of Excitation and Inhibitionsupporting

confidence: 53%

Estrus-Cycle Regulation of Cortical Inhibition

et al. 2019

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“…The exclusion criteria included neurological disorders, brain injury, current use of analgesic medication, substance abuse or dependence and mental disorders. We also excluded women from the experiment due to possible EEG changes associated with the menstrual cycle [69][70][71][72] . All participants were right-handed and had normal or corrected-to-normal vision, and the mean ± standard deviation of their age was 21.97 ± 1.88 years.…”

Section: Methodsmentioning

confidence: 99%

Resting-state EEG activity predicts frontoparietal network reconfiguration and improved attentional performance

Rogala

Kublik

Krauz

et al. 2020

Sci Rep

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Mounting evidence indicates that resting-state EEG activity is related to various cognitive functions. To trace physiological underpinnings of this relationship, we investigated EEG and behavioral performance of 36 healthy adults recorded at rest and during visual attention tasks: visual search and gun shooting. All measures were repeated two months later to determine stability of the results. Correlation analyses revealed that within the range of 2-45 Hz, at rest, beta-2 band power correlated with the strength of frontoparietal connectivity and behavioral performance in both sessions. Participants with lower global beta-2 resting-state power (gB2rest) showed weaker frontoparietal connectivity and greater capacity for its modifications, as indicated by changes in phase correlations of the EEG signals. At the same time shorter reaction times and improved shooting accuracy were found, in both test and retest, in participants with low gB2rest compared to higher gB2rest values. We posit that weak frontoparietal connectivity permits flexible network reconfigurations required for improved performance in everyday tasks.One of the main goals of neuroscience is to understand how neuronal activity organizes behavior. To elucidate this relationship, many studies have focused on the putative links between task-related neuronal electrical activity and behavioral performance 1-5 . In parallel, BOLD (blood-oxygen-level-dependent) imaging investigations have revealed that (i) resting-state (spontaneous) connectivity correlates with functionally activated networks 6-14 , and (ii) specifically with the performance of various cognitive functions, such as attention 15 , working memory 16,17 and fluid intelligence 18 . It has been further suggested that such correlations could be explained by the individual characteristics of brain networks 19,20 . However, the uncertain physiological origins of hemodynamic signals 21 provide limited insight into the mechanisms governing the relationship between resting-state and task-related activations and therefore behavioral outcomes.Recording electrophysiological activity is one way that the relationship between resting-state and behavioral performance can be directly assessed. Indeed, several investigations have already revealed correlations between specific EEG bands and different aspects of cognitive performance. For example, in the attentional domain, alpha oscillations have been proposed to clear sensory information from distractors 22 , the beta to gamma band ratio can assure critical-state dynamics for optimal information processing 23 and alpha and beta band activity can reduce attentional investment during rest 24 . Yet, none of the proposed mechanisms have characterized the intrinsic properties of resting-state networks such as power of EEG bands and connectivity, and how they could relate to functional connectivity underlying behavioral performance.We hypothesized that specific electrophysiological signatures of spontaneous, individual EEG activity in large-scale networks would predic...

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“…Schwarzkopf et al, 2012). Moreover, bandwidth of sensory gamma oscillations varies between modalities in a range between 30 and more than 100 Hz (visual: Jia et al 2011;Friese et al 2016;Sumner et al 2018;somatosensory: Wahnoun et al 2015;Ryun et al 2017;von Lautz et al 2017;auditory: Edwards et al 2005;Griffiths et al 2010;Mulert et al 2011). Given this large variability within and across modalities, narrow tuning of direct multisensory communication channels would, in fact, be surprising.…”

Section: Behavioral Benefits Of Cross-modal Congruence May Involve Famentioning

confidence: 99%

Synchronization of sensory gamma oscillations promotes multisensory communication

Misselhorn

Schwab

Schneider

et al. 2019

Preprint

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AcknowledgementsThis work was supported by grants from the DFG (SFB 936/A3/Z1, SFB TRR 169/B1 and SPP 1665/EN 533/13-1 to AKE; SPP 1665/SCHN 1511/1-2 to TRS) and the EU (ERC-2010-AdG-269716 to AKE). The authors would like to thank Karin Deazle for help with recruitment of participants and data recording. AbstractRhythmic neuronal activity in the gamma range is a signature of active cortical processing and its synchronization across distant sites has been proposed as a fundamental mechanism of network communication. While this has been shown within sensory modalities, we tested whether crosstalk between the senses relies on similar mechanisms. In two consecutive experiments, we used a task in which human participants (male and female) matched amplitude changes of concurrent visual, auditory and tactile stimuli. In this task, matching of congruent stimuli was associated with a behavioral benefit compared to matching of incongruent stimuli. In the first experiment, we used source-level analysis of high-density electroencephalography (EEG) and observed that cross-modal matching of congruent inputs was associated with relatively weaker gamma band coherence between early sensory regions.Next, we used bifocal high-definition transcranial alternating current stimulation (hd-tACS) to manipulate the strength of coupling between sensory cortices. Here, we used a lateralized version of the task in which hd-tACS was applied either ipsilateral or contralateral to the hemisphere receiving sensory stimuli. Ipsilateral gamma, but not alpha stimulation slowed responses to congruent trials whereas responding to incongruent trials was not changed by hd-tACS. We speculate that fast responding to congruent stimuli involves decoupling of sensory gamma oscillations, which was prevented by hd-tACS. Collectively, these results indicate that coordinated sensory gamma oscillations play an important role for direct cross-modal interactions. We suggest that, comparable to interactions within sensory streams, phase-coupled gamma oscillations might provide the functional scaffold for cross-modal communication. Significance statementCortical gamma oscillations structure segregated neural activity and were suggested to represent a fundamental mechanism of network communication. While there is ample evidence for the role of longrange gamma synchronization in unisensory processing, its significance in multisensory networks is still unclear. We show that coordinated sensory gamma oscillations play an important role for direct cross-modal interactions and propose that phase synchronization promotes communication between sensory cortices. To that end, we carried out two consecutive experiments using state-of-the-art highdensity electroencephalography (EEG) and high-definition transcranial alternating current stimulation (hd-tACS). By complementing an observational with an interventional method, we provide novel evidence for the role of synchronized gamma oscillations in multisensory communication.

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Peak visual gamma frequency is modified across the healthy menstrual cycle

Cited by 33 publications

References 94 publications

Estrus-Cycle Regulation of Cortical Inhibition

Estrus-Cycle Regulation of Cortical Inhibition

Resting-state EEG activity predicts frontoparietal network reconfiguration and improved attentional performance

Synchronization of sensory gamma oscillations promotes multisensory communication

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